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- W4384155008 abstract "Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic transcription. Jumonji C domain–containing histone demethylases (JMJs) dynamically control the level of histone methylations. However, how JMJ activity is generally regulated is unknown. We found that the tricarboxylic acid cycle–associated enzyme α-ketoglutarate (α-KG) dehydrogenase (KGDH) entered the nucleus, where it interacted with various JMJs to regulate α-KG–dependent histone demethylations by JMJs, and thus controlled genome-wide gene expression in plants. We show that nuclear targeting is regulated by environmental signals and that KGDH is enriched at thousands of loci in Arabidopsis thaliana . Chromatin-bound KGDH catalyzes α-KG decarboxylation and thus may limit its local availability to KGDH-coupled JMJs, inhibiting histone demethylation. Thus, our results uncover a regulatory mechanism for histone demethylations by JMJs." @default.
- W4384155008 created "2023-07-14" @default.
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- W4384155008 date "2023-07-14" @default.
- W4384155008 modified "2023-09-30" @default.
- W4384155008 title "Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase" @default.
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- W4384155008 doi "https://doi.org/10.1126/science.adf8822" @default.
- W4384155008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37440635" @default.
- W4384155008 hasPublicationYear "2023" @default.
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