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- W4384155135 abstract "Gene expression is controlled by the precise activation and repression of transcription. Repression is mediated by specialized transcription factors (TFs) that recruit co-repressors (CoRs) to silence transcription, even in the presence of activating cues. However, whether CoRs can dominantly silence all enhancers or display distinct specificities is unclear. In this work, we report that most enhancers in Drosophila can be repressed by only a subset of CoRs, and enhancers classified by CoR sensitivity show distinct chromatin features, function, TF motifs, and binding. Distinct TF motifs render enhancers more resistant or sensitive to specific CoRs, as we demonstrate by motif mutagenesis and addition. These CoR-enhancer compatibilities constitute an additional layer of regulatory specificity that allows differential regulation at close genomic distances and is indicative of distinct mechanisms of transcriptional repression." @default.
- W4384155135 created "2023-07-14" @default.
- W4384155135 creator A5007511281 @default.
- W4384155135 creator A5037662850 @default.
- W4384155135 creator A5052020232 @default.
- W4384155135 creator A5089151262 @default.
- W4384155135 date "2023-07-14" @default.
- W4384155135 modified "2023-09-30" @default.
- W4384155135 title "Widespread regulatory specificities between transcriptional co-repressors and enhancers in <i>Drosophila</i>" @default.
- W4384155135 cites W1559742681 @default.
- W4384155135 cites W1867052108 @default.
- W4384155135 cites W1973129665 @default.
- W4384155135 cites W1977690815 @default.
- W4384155135 cites W1978116091 @default.
- W4384155135 cites W1979256988 @default.
- W4384155135 cites W1979647722 @default.
- W4384155135 cites W198005847 @default.
- W4384155135 cites W1981030303 @default.
- W4384155135 cites W1986586739 @default.
- W4384155135 cites W1991085321 @default.
- W4384155135 cites W1992125440 @default.
- W4384155135 cites W1999330214 @default.
- W4384155135 cites W1999491381 @default.
- W4384155135 cites W2011609862 @default.
- W4384155135 cites W2016015848 @default.
- W4384155135 cites W2028521239 @default.
- W4384155135 cites W2029492292 @default.
- W4384155135 cites W2044969911 @default.
- W4384155135 cites W2048122656 @default.
- W4384155135 cites W2052443837 @default.
- W4384155135 cites W2056625688 @default.
- W4384155135 cites W2060115129 @default.
- W4384155135 cites W2073208713 @default.
- W4384155135 cites W2077874719 @default.
- W4384155135 cites W2081267078 @default.
- W4384155135 cites W2085443300 @default.
- W4384155135 cites W2097469177 @default.
- W4384155135 cites W2099105062 @default.
- W4384155135 cites W2103873282 @default.
- W4384155135 cites W2104870341 @default.
- W4384155135 cites W2107281049 @default.
- W4384155135 cites W2114104545 @default.
- W4384155135 cites W2114270664 @default.
- W4384155135 cites W2122895566 @default.
- W4384155135 cites W2124985265 @default.
- W4384155135 cites W2130174998 @default.
- W4384155135 cites W2131478115 @default.
- W4384155135 cites W2132117628 @default.
- W4384155135 cites W2134771103 @default.
- W4384155135 cites W2135061355 @default.
- W4384155135 cites W2135185213 @default.
- W4384155135 cites W2137540340 @default.
- W4384155135 cites W2141215651 @default.
- W4384155135 cites W2141673314 @default.
- W4384155135 cites W2142768995 @default.
- W4384155135 cites W2150090219 @default.
- W4384155135 cites W2151240250 @default.
- W4384155135 cites W2158834413 @default.
- W4384155135 cites W2162296692 @default.
- W4384155135 cites W2171808845 @default.
- W4384155135 cites W2247766769 @default.
- W4384155135 cites W2253889865 @default.
- W4384155135 cites W2471978271 @default.
- W4384155135 cites W2505821435 @default.
- W4384155135 cites W2523115422 @default.
- W4384155135 cites W2745090396 @default.
- W4384155135 cites W2758874308 @default.
- W4384155135 cites W2786204582 @default.
- W4384155135 cites W2791429709 @default.
- W4384155135 cites W2804554615 @default.
- W4384155135 cites W2806844404 @default.
- W4384155135 cites W2905555535 @default.
- W4384155135 cites W2911144414 @default.
- W4384155135 cites W2919831311 @default.
- W4384155135 cites W2945999435 @default.
- W4384155135 cites W2949147174 @default.
- W4384155135 cites W2967108727 @default.
- W4384155135 cites W3009177557 @default.
- W4384155135 cites W3100755790 @default.
- W4384155135 cites W3175752499 @default.
- W4384155135 cites W3209622365 @default.
- W4384155135 cites W4205345182 @default.
- W4384155135 cites W4225259708 @default.
- W4384155135 cites W4242700871 @default.
- W4384155135 cites W4280563114 @default.
- W4384155135 cites W4281893299 @default.
- W4384155135 cites W4294541781 @default.
- W4384155135 cites W4295958426 @default.
- W4384155135 cites W4307449862 @default.
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- W4384155135 doi "https://doi.org/10.1126/science.adf6149" @default.
- W4384155135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37440660" @default.
- W4384155135 hasPublicationYear "2023" @default.
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