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• W4384155184 abstract "Abstract Background Human caliciviruses are the leading cause of acute gastroenteritis and foodborne diarrheal diseases in all age groups worldwide, with an increased burden in developing countries. As there is no routine surveillance, epidemiological data is limited in Ethiopia. This study aimed to investigate the prevalence and associated factors of human caliciviruses among patients suffering from gastroenteritis in the selected health facilities of Amhara National Regional State, Northwest Ethiopia. Methods A multi-center health facility-based cross-sectional study was conducted from May 2021 to November 2021. A total of 550 study participants were proportionately assigned to the different health facilities in four study areas. A systematic random sampling technique was used to select participants. A stool sample was collected and analyzed with a one-step real-time reverse transcription polymerase chain reaction. Data were gathered using a questionnaire and analyzed by SPSS. A descriptive analysis was performed. Binary and multivariable logistic regression analyses were done to determine the association between the dependent and independent variables. Variables with p-value < 0.05, at the 95%CI, were considered statistically significant. Result The prevalence of norovirus among all age groups was 8.9% (95% CI: 6.6, 11.6). Specifically, it was higher among elder people (33.3%) and under-5 children (12.5%). Sapovirus was not detected. Both norovirus genogroup I and II were detected, but genogroup II was the predominant, 82.6%. All of the respondents were diarrheic, but only 20% of them had a history of vomiting. The odds of norovirus infection among respondents from the Debre Tabor and Bahir Dar areas were significantly higher. Similarly, elder people and under-5 children were more affected than their adult-age counterparts (p < 0.05). Furthermore, previous history of acute gastroenteritis, family contact history with related cases, and poor hand-washing practice were statistically significant factors associated with norovirus infections (p < 0.05). Conclusion The prevalence of norovirus was considerably high. Norovirus-GII was predominant. The positivity rate of norovirus was higher among the elderly and under-5 children. The distribution of the norovirus, and their genogroups, varies across the four study areas." @default.
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• W4384155184 date "2023-07-13" @default.
• W4384155184 modified "2023-09-25" @default.
• W4384155184 title "Prevalence and associated factors of human caliciviruses among patients suffering from gastroenteritis in the Amhara National Regional State, Northwest Ethiopia" @default.
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• W4384155184 doi "https://doi.org/10.21203/rs.3.rs-3151886/v1" @default.
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