FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384155251> ?p ?o ?g. }

• W4384155251 abstract "Abstract Precision medicine requires highly scalable methods of multiplexed biomarker quantification that can accurately describe patient physiology. Unfortunately, contemporary molecular detection methods are generally limited to a dynamic range of sensitivity spanning just 3–4 orders of magnitude, whereas the actual physiological dynamic range of the human plasma proteome spans more than 10 orders of magnitude. Current methods rely on sample splitting and differential dilution to compensate for this mismatch, but such measures greatly limit the reproducibility and scalability that can be achieved—in particular, the effects of non-linear dilution can greatly confound the analysis of multiplexed assays. We describe here a two-pronged strategy for equalizing the signal generated by each analyte in a multiplexed panel, thereby enabling simultaneous quantification of targets spanning a wide range of concentrations. We apply our ‘EVROS’ strategy to a proximity ligation assay and demonstrate simultaneous quantification of four analytes present at concentrations spanning from low femtomolar to mid-nanomolar levels. In this initial demonstration, we achieve a dynamic range spanning seven orders of magnitude in a single 5 µl sample of undiluted human serum, highlighting the opportunity to achieve sensitive, accurate detection of diverse analytes in a highly multiplexed fashion." @default.
• W4384155251 created "2023-07-14" @default.
• W4384155251 creator A5020581130 @default.
• W4384155251 creator A5035416695 @default.
• W4384155251 creator A5037539542 @default.
• W4384155251 creator A5043343366 @default.
• W4384155251 creator A5060684894 @default.
• W4384155251 creator A5068399737 @default.
• W4384155251 creator A5070976556 @default.
• W4384155251 creator A5085810236 @default.
• W4384155251 creator A5089165916 @default.
• W4384155251 date "2023-07-13" @default.
• W4384155251 modified "2023-10-14" @default.
• W4384155251 title "Extending the dynamic range of biomarker quantification through molecular equalization" @default.
• W4384155251 cites W1967501266 @default.
• W4384155251 cites W1975290591 @default.
• W4384155251 cites W1984096033 @default.
• W4384155251 cites W2020474446 @default.
• W4384155251 cites W2033692444 @default.
• W4384155251 cites W2041677964 @default.
• W4384155251 cites W2050271637 @default.
• W4384155251 cites W2053003735 @default.
• W4384155251 cites W2092598739 @default.
• W4384155251 cites W2092956762 @default.
• W4384155251 cites W2098556604 @default.
• W4384155251 cites W2104841504 @default.
• W4384155251 cites W2137166024 @default.
• W4384155251 cites W2142706826 @default.
• W4384155251 cites W2148304424 @default.
• W4384155251 cites W2172116519 @default.
• W4384155251 cites W2253972942 @default.
• W4384155251 cites W2508169637 @default.
• W4384155251 cites W2522699003 @default.
• W4384155251 cites W2782941307 @default.
• W4384155251 cites W2952048284 @default.
• W4384155251 cites W3016940372 @default.
• W4384155251 cites W3021659033 @default.
• W4384155251 cites W3026163675 @default.
• W4384155251 cites W4384155251 @default.
• W4384155251 doi "https://doi.org/10.1038/s41467-023-39772-z" @default.
• W4384155251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37443317" @default.
• W4384155251 hasPublicationYear "2023" @default.
• W4384155251 type Work @default.
• W4384155251 citedByCount "1" @default.
• W4384155251 countsByYear W43841552512023 @default.
• W4384155251 crossrefType "journal-article" @default.
• W4384155251 hasAuthorship W4384155251A5020581130 @default.
• W4384155251 hasAuthorship W4384155251A5035416695 @default.
• W4384155251 hasAuthorship W4384155251A5037539542 @default.
• W4384155251 hasAuthorship W4384155251A5043343366 @default.
• W4384155251 hasAuthorship W4384155251A5060684894 @default.
• W4384155251 hasAuthorship W4384155251A5068399737 @default.
• W4384155251 hasAuthorship W4384155251A5070976556 @default.
• W4384155251 hasAuthorship W4384155251A5085810236 @default.
• W4384155251 hasAuthorship W4384155251A5089165916 @default.
• W4384155251 hasBestOaLocation W43841552511 @default.
• W4384155251 hasConcept C10390740 @default.
• W4384155251 hasConcept C119128265 @default.
• W4384155251 hasConcept C185592680 @default.
• W4384155251 hasConcept C186060115 @default.
• W4384155251 hasConcept C19275194 @default.
• W4384155251 hasConcept C2781197716 @default.
• W4384155251 hasConcept C31972630 @default.
• W4384155251 hasConcept C41008148 @default.
• W4384155251 hasConcept C43617362 @default.
• W4384155251 hasConcept C55493867 @default.
• W4384155251 hasConcept C76155785 @default.
• W4384155251 hasConcept C86803240 @default.
• W4384155251 hasConcept C87133666 @default.
• W4384155251 hasConcept C9893847 @default.
• W4384155251 hasConceptScore W4384155251C10390740 @default.
• W4384155251 hasConceptScore W4384155251C119128265 @default.
• W4384155251 hasConceptScore W4384155251C185592680 @default.
• W4384155251 hasConceptScore W4384155251C186060115 @default.
• W4384155251 hasConceptScore W4384155251C19275194 @default.
• W4384155251 hasConceptScore W4384155251C2781197716 @default.
• W4384155251 hasConceptScore W4384155251C31972630 @default.
• W4384155251 hasConceptScore W4384155251C41008148 @default.
• W4384155251 hasConceptScore W4384155251C43617362 @default.
• W4384155251 hasConceptScore W4384155251C55493867 @default.
• W4384155251 hasConceptScore W4384155251C76155785 @default.
• W4384155251 hasConceptScore W4384155251C86803240 @default.
• W4384155251 hasConceptScore W4384155251C87133666 @default.
• W4384155251 hasConceptScore W4384155251C9893847 @default.
• W4384155251 hasFunder F4320306705 @default.
• W4384155251 hasIssue "1" @default.
• W4384155251 hasLocation W43841552511 @default.
• W4384155251 hasLocation W43841552512 @default.
• W4384155251 hasLocation W43841552513 @default.
• W4384155251 hasLocation W43841552514 @default.
• W4384155251 hasOpenAccess W4384155251 @default.
• W4384155251 hasPrimaryLocation W43841552511 @default.
• W4384155251 hasRelatedWork W1568084954 @default.
• W4384155251 hasRelatedWork W1966671075 @default.
• W4384155251 hasRelatedWork W1977192127 @default.
• W4384155251 hasRelatedWork W2085847874 @default.
• W4384155251 hasRelatedWork W2159789625 @default.
• W4384155251 hasRelatedWork W3157096763 @default.
• W4384155251 hasRelatedWork W4247975119 @default.
• W4384155251 hasRelatedWork W4297957418 @default.

• next