Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384156130> ?p ?o ?g. }
- W4384156130 abstract "Abstract Recently, membrane‐modified mammalian exosomes have been considered strong candidates for targeted drug delivery carriers because of their biocompatibility, biodistribution, and low immune response. However, the widespread utilization of exosomes still requires overcoming several challenging issues, including low stability, high production cost, and low mass productivity. Therefore, artificial extracellular vesicles (EVs) derived from cell membranes or liposomes containing various lipids have been suggested. However, only a few meet the demands of cost‐effective mass production and durability of EVs. Therefore, this study investigates the feasibility of replacing mammalian cell exosomes and liposomes with plant‐derived extracellular vesicles (pEVs) as targeted drug delivery carriers. They are characterized by nontoxicity, high stability, and high yield. Adding a functionalizable lipid moiety with a maleimide group at the membrane of grapefruit‐derived pEVs imparts targeting ability. The targeting function can be easily enhanced by attaching an aptamer using click chemistry. Indeed, treatment of brain cells with pEV‐aptamers (hCMEC/D3 and U87MG) confirms that aptamer functionalization of pEV enhanced selective cellular uptake. Functionalization of the pEV membrane using aptamer is expected to be effective in providing low‐cost and mass‐producible targeted drug delivery carriers with similar efficacy as mammalian exosomes or liposomes." @default.
- W4384156130 created "2023-07-14" @default.
- W4384156130 creator A5001822994 @default.
- W4384156130 creator A5007328060 @default.
- W4384156130 creator A5035593633 @default.
- W4384156130 creator A5039472466 @default.
- W4384156130 creator A5090254873 @default.
- W4384156130 date "2023-07-13" @default.
- W4384156130 modified "2023-10-14" @default.
- W4384156130 title "Surface‐Functionalizable Plant‐Derived Extracellular Vesicles for Targeted Drug Delivery Carrier Using Grapefruit" @default.
- W4384156130 cites W1993337563 @default.
- W4384156130 cites W1996719014 @default.
- W4384156130 cites W2000678720 @default.
- W4384156130 cites W2066788401 @default.
- W4384156130 cites W2085898732 @default.
- W4384156130 cites W2330369687 @default.
- W4384156130 cites W2465939084 @default.
- W4384156130 cites W2561631543 @default.
- W4384156130 cites W2761425229 @default.
- W4384156130 cites W2790320526 @default.
- W4384156130 cites W2790852710 @default.
- W4384156130 cites W2796081672 @default.
- W4384156130 cites W2885214828 @default.
- W4384156130 cites W2889615651 @default.
- W4384156130 cites W2914600269 @default.
- W4384156130 cites W2925372744 @default.
- W4384156130 cites W2948520738 @default.
- W4384156130 cites W2970895669 @default.
- W4384156130 cites W2982334421 @default.
- W4384156130 cites W2999469970 @default.
- W4384156130 cites W3005104290 @default.
- W4384156130 cites W3030526746 @default.
- W4384156130 cites W3038210287 @default.
- W4384156130 cites W3098825698 @default.
- W4384156130 cites W3100259775 @default.
- W4384156130 cites W3108455023 @default.
- W4384156130 cites W3118968579 @default.
- W4384156130 cites W3128033077 @default.
- W4384156130 cites W3154091431 @default.
- W4384156130 cites W3164623808 @default.
- W4384156130 cites W3175526367 @default.
- W4384156130 cites W3175628958 @default.
- W4384156130 cites W3176695533 @default.
- W4384156130 cites W3210711444 @default.
- W4384156130 cites W4200260237 @default.
- W4384156130 cites W4210669406 @default.
- W4384156130 cites W4281298594 @default.
- W4384156130 cites W4284973969 @default.
- W4384156130 cites W4311777527 @default.
- W4384156130 doi "https://doi.org/10.1002/admi.202300220" @default.
- W4384156130 hasPublicationYear "2023" @default.
- W4384156130 type Work @default.
- W4384156130 citedByCount "0" @default.
- W4384156130 crossrefType "journal-article" @default.
- W4384156130 hasAuthorship W4384156130A5001822994 @default.
- W4384156130 hasAuthorship W4384156130A5007328060 @default.
- W4384156130 hasAuthorship W4384156130A5035593633 @default.
- W4384156130 hasAuthorship W4384156130A5039472466 @default.
- W4384156130 hasAuthorship W4384156130A5090254873 @default.
- W4384156130 hasBestOaLocation W43841561301 @default.
- W4384156130 hasConcept C104317684 @default.
- W4384156130 hasConcept C115537861 @default.
- W4384156130 hasConcept C12554922 @default.
- W4384156130 hasConcept C126511603 @default.
- W4384156130 hasConcept C128972844 @default.
- W4384156130 hasConcept C130316041 @default.
- W4384156130 hasConcept C13245373 @default.
- W4384156130 hasConcept C145059251 @default.
- W4384156130 hasConcept C147789679 @default.
- W4384156130 hasConcept C1491633281 @default.
- W4384156130 hasConcept C153911025 @default.
- W4384156130 hasConcept C171250308 @default.
- W4384156130 hasConcept C18150654 @default.
- W4384156130 hasConcept C185154212 @default.
- W4384156130 hasConcept C185592680 @default.
- W4384156130 hasConcept C191897082 @default.
- W4384156130 hasConcept C192562407 @default.
- W4384156130 hasConcept C20518536 @default.
- W4384156130 hasConcept C2777230088 @default.
- W4384156130 hasConcept C2779820397 @default.
- W4384156130 hasConcept C28005876 @default.
- W4384156130 hasConcept C2908689518 @default.
- W4384156130 hasConcept C41625074 @default.
- W4384156130 hasConcept C55493867 @default.
- W4384156130 hasConcept C86803240 @default.
- W4384156130 hasConceptScore W4384156130C104317684 @default.
- W4384156130 hasConceptScore W4384156130C115537861 @default.
- W4384156130 hasConceptScore W4384156130C12554922 @default.
- W4384156130 hasConceptScore W4384156130C126511603 @default.
- W4384156130 hasConceptScore W4384156130C128972844 @default.
- W4384156130 hasConceptScore W4384156130C130316041 @default.
- W4384156130 hasConceptScore W4384156130C13245373 @default.
- W4384156130 hasConceptScore W4384156130C145059251 @default.
- W4384156130 hasConceptScore W4384156130C147789679 @default.
- W4384156130 hasConceptScore W4384156130C1491633281 @default.
- W4384156130 hasConceptScore W4384156130C153911025 @default.
- W4384156130 hasConceptScore W4384156130C171250308 @default.
- W4384156130 hasConceptScore W4384156130C18150654 @default.
- W4384156130 hasConceptScore W4384156130C185154212 @default.
- W4384156130 hasConceptScore W4384156130C185592680 @default.