FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384156394> ?p ?o ?g. }

• W4384156394 endingPage "104893" @default.
• W4384156394 startingPage "104893" @default.
• W4384156394 abstract "As a widespread epidemic virus, genotype II of the grass carp reovirus poses a significant threat to the grass carp farming industry in China. Different genotype II isolates cause different degrees of virulence, although the underlying pathogenic mechanisms remain largely unknown. In this work, infections of grass carp with the virulent isolate grass carp reovirus (GCRV)-HN1307 and the avirulent isolate GCRV-GD1108 were performed to reveal a possible mutual transcriptional discrepancy. More differentially expressed genes (DEGs) were identified in the HN1307-infected group, which defined a grossly similar gene ontology (GO) pattern and different pathway landscape as the GD1108-infected group. Gene set enrichment analysis revealed that pathways related to innate immunity and metabolism were reciprocally activated and suppressed, respectively, following infection withHN1307, compared with GD1108. The trend analysis further indicated that immune-related pathways were involved in one of the four statistically significant profiles. Network analysis of transcription factor-gene interactions and protein-protein interactions on the immune-related profile suggested that among the core transcriptional factors (TFs) (UBTF, HCFC1, MAZ, MAX, and NRF1) and the hub proteins (Tlr3, Tlr7, Tlr9, Irf3, and Irf7), the latter were highly enriched in the toll-like receptor signaling pathway. Real-time quantitative PCR performed on the selected mRNAs validated the relative expression. This work will provide insights into the distinct transcriptional signatures from avirulent and virulent isolates of GCRV, which may contribute to the development of products for prevention." @default.
• W4384156394 created "2023-07-14" @default.
• W4384156394 creator A5028680864 @default.
• W4384156394 creator A5038699958 @default.
• W4384156394 creator A5039030237 @default.
• W4384156394 creator A5039859455 @default.
• W4384156394 creator A5047405665 @default.
• W4384156394 creator A5061867449 @default.
• W4384156394 creator A5062662732 @default.
• W4384156394 creator A5072315367 @default.
• W4384156394 creator A5073266499 @default.
• W4384156394 creator A5079286679 @default.
• W4384156394 date "2023-10-01" @default.
• W4384156394 modified "2023-10-16" @default.
• W4384156394 title "Comparative transcriptional analysis between virulent isolate HN1307 and avirulent isolate GD1108 of grass carp reovirus genotype II" @default.
• W4384156394 cites W1566831845 @default.
• W4384156394 cites W1971878456 @default.
• W4384156394 cites W1979772572 @default.
• W4384156394 cites W1998176766 @default.
• W4384156394 cites W1999574084 @default.
• W4384156394 cites W2010393536 @default.
• W4384156394 cites W2027385417 @default.
• W4384156394 cites W2076033230 @default.
• W4384156394 cites W2081508444 @default.
• W4384156394 cites W2100305481 @default.
• W4384156394 cites W2101142880 @default.
• W4384156394 cites W2103912979 @default.
• W4384156394 cites W2123183408 @default.
• W4384156394 cites W2140729960 @default.
• W4384156394 cites W2155142785 @default.
• W4384156394 cites W2159065029 @default.
• W4384156394 cites W2170551349 @default.
• W4384156394 cites W2343805865 @default.
• W4384156394 cites W2537623931 @default.
• W4384156394 cites W2566050392 @default.
• W4384156394 cites W2767826728 @default.
• W4384156394 cites W2891930398 @default.
• W4384156394 cites W2938799133 @default.
• W4384156394 cites W2952679853 @default.
• W4384156394 cites W2979996660 @default.
• W4384156394 cites W2989238711 @default.
• W4384156394 cites W2994699902 @default.
• W4384156394 cites W3003341274 @default.
• W4384156394 cites W3023775040 @default.
• W4384156394 cites W3096722177 @default.
• W4384156394 cites W3108956953 @default.
• W4384156394 cites W3118946259 @default.
• W4384156394 cites W3121187057 @default.
• W4384156394 cites W3131231345 @default.
• W4384156394 cites W3136699424 @default.
• W4384156394 cites W3156567397 @default.
• W4384156394 cites W3162961947 @default.
• W4384156394 cites W3186260442 @default.
• W4384156394 cites W3197554087 @default.
• W4384156394 cites W4213448335 @default.
• W4384156394 cites W4283214393 @default.
• W4384156394 cites W4367554865 @default.
• W4384156394 doi "https://doi.org/10.1016/j.dci.2023.104893" @default.
• W4384156394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37451563" @default.
• W4384156394 hasPublicationYear "2023" @default.
• W4384156394 type Work @default.
• W4384156394 citedByCount "0" @default.
• W4384156394 crossrefType "journal-article" @default.
• W4384156394 hasAuthorship W4384156394A5028680864 @default.
• W4384156394 hasAuthorship W4384156394A5038699958 @default.
• W4384156394 hasAuthorship W4384156394A5039030237 @default.
• W4384156394 hasAuthorship W4384156394A5039859455 @default.
• W4384156394 hasAuthorship W4384156394A5047405665 @default.
• W4384156394 hasAuthorship W4384156394A5061867449 @default.
• W4384156394 hasAuthorship W4384156394A5062662732 @default.
• W4384156394 hasAuthorship W4384156394A5072315367 @default.
• W4384156394 hasAuthorship W4384156394A5073266499 @default.
• W4384156394 hasAuthorship W4384156394A5079286679 @default.
• W4384156394 hasConcept C104317684 @default.
• W4384156394 hasConcept C135763542 @default.
• W4384156394 hasConcept C136449434 @default.
• W4384156394 hasConcept C159047783 @default.
• W4384156394 hasConcept C2776460866 @default.
• W4384156394 hasConcept C2776709828 @default.
• W4384156394 hasConcept C2776966659 @default.
• W4384156394 hasConcept C2778420691 @default.
• W4384156394 hasConcept C2780209191 @default.
• W4384156394 hasConcept C2781257293 @default.
• W4384156394 hasConcept C2909208804 @default.
• W4384156394 hasConcept C505870484 @default.
• W4384156394 hasConcept C54355233 @default.
• W4384156394 hasConcept C60987743 @default.
• W4384156394 hasConcept C86803240 @default.
• W4384156394 hasConcept C8891405 @default.
• W4384156394 hasConcept C89423630 @default.
• W4384156394 hasConceptScore W4384156394C104317684 @default.
• W4384156394 hasConceptScore W4384156394C135763542 @default.
• W4384156394 hasConceptScore W4384156394C136449434 @default.
• W4384156394 hasConceptScore W4384156394C159047783 @default.
• W4384156394 hasConceptScore W4384156394C2776460866 @default.
• W4384156394 hasConceptScore W4384156394C2776709828 @default.
• W4384156394 hasConceptScore W4384156394C2776966659 @default.
• W4384156394 hasConceptScore W4384156394C2778420691 @default.

• next