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• W4384156502 abstract "The perivascular niche is a complex signaling hub, which promotes tumor growth and metastatic dissemination in a context-dependent manner. Direct and paracrine cell–cell interactions at the perivascular niche rewire cancer cell phenotypes. Tumor-secreted factors favor premetastatic niche formation altering the phenotypic identity of perivascular stroma cells. Targeting the perivascular niche may enhance the efficacy of anticancer therapies and prevent metastatic spreading. ability of tumor cells to undergo molecular and phenotypic changes to adapt to evolving microenvironment. subpopulation of tumor cells which exhibits self-renewal and differentiation capacities and drives tumor initiation and progression. nongenetic mechanism leading to reprograming under exposure to therapeutic pressure in a population of cancer cells which evade cell death giving rise to therapy-resistant relapse and refractory disease. mesoderm-derived heterogeneous group of cells forming a single cell layer endothelium in the blood and lymphatic vasculature systems which constitute the barrier between vessels and surrounding tissues. cellular process whereby endothelial cells acquire mesenchymal features when losing endothelial phenotype. cellular process whereby epithelial cells acquire mesenchymal features when losing epithelial phenotype. the most common type of mesenchymal cells present in a connective tissue which produce the structural framework for surrounding tissue. population of vessel-associated cells including smooth muscle cells and pericytes that originate from mesoderm or ectoderm and cover albuminal surface of blood vessels, regulating crosstalk between EC and neighboring tissue. specialized type of mural cells which are associated with capillaries and post-capillary venules and share the basement membrane with endothelial cells and can directly interact with ECs through holes in the basement membrane. stromal cells surrounding blood and/or lymphatic vessels. highly heterogeneous population of connective tissue cells that provide structural support and nutrients to surrounding organs and/or tissue." @default.
• W4384156502 created "2023-07-14" @default.
• W4384156502 creator A5006432893 @default.
• W4384156502 creator A5008853880 @default.
• W4384156502 creator A5061315439 @default.
• W4384156502 date "2023-07-01" @default.
• W4384156502 modified "2023-10-17" @default.
• W4384156502 title "Perivascular niches: critical hubs in cancer evolution" @default.
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