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• W4384156522 endingPage "76" @default.
• W4384156522 startingPage "60" @default.
• W4384156522 abstract "Mutations in SHH and several other genes encoding components of the Hedgehog signaling pathway have been associated with holoprosencephaly syndromes, with craniofacial anomalies ranging in severity from cyclopia to facial cleft to midfacial and mandibular hypoplasia. Studies in animal models have revealed that SHH signaling plays crucial roles at multiple stages of craniofacial morphogenesis, from cranial neural crest cell survival to growth and patterning of the facial primordia to organogenesis of the palate, mandible, tongue, tooth, and taste bud formation and homeostasis. This article provides a summary of the major findings in studies of the roles of SHH signaling in craniofacial development, with emphasis on recent advances in the understanding of the molecular and cellular mechanisms regulating the SHH signaling pathway activity and those involving SHH signaling in the formation and patterning of craniofacial structures." @default.
• W4384156522 created "2023-07-14" @default.
• W4384156522 creator A5016740718 @default.
• W4384156522 creator A5019190546 @default.
• W4384156522 creator A5050198479 @default.
• W4384156522 creator A5082252134 @default.
• W4384156522 date "2023-09-01" @default.
• W4384156522 modified "2023-10-17" @default.
• W4384156522 title "Sonic hedgehog signaling in craniofacial development" @default.
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