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• W4384156585 abstract "Nearly 70% of plant virus species are transmitted by specific insect vectors, and this vector transmission is key for disease outbreaks. Understanding the mechanism by which the insects transmit the specific virus is critical for predicting and controlling the viral disease. Autophagy in insect vectors is activated through various pathways depending on the insect–virus combination after the insect acquires the plant reovirus. Plant reoviruses not only escape degradation by blocking fusion of autophagosomes and lysosomes, but also use unfused autophagosomes to assemble new virions or cross multiple membrane barriers in the insect. Entry of a plant reovirus into the insect vector can activate mitophagy to degrade damaged mitochondria to avoid mitochondria-dependent apoptosis, providing an optimal intracellular environment for persistent virus survival. Plant reoviruses, transmitted only by insect vectors, seriously threaten global cereal production. Understanding how insect vectors efficiently transmit the viruses is key to controlling the viral diseases. Autophagy commonly plays important roles in plant host defense against virus infection, but recent studies have shown that plant reoviruses can hijack the autophagy pathway in insect cells to enable their persistence in the insect and continued transmission to plants. Here, we summarize and discuss new insights on viral activation, evasion, regulation, and manipulation of autophagy within the insect vectors and the role of autophagy in virus survival in insect vectors. Deeper knowledge of the functions of autophagy in vectors may lead to novel strategies for blocking transmission of insect-borne plant viruses. Plant reoviruses, transmitted only by insect vectors, seriously threaten global cereal production. Understanding how insect vectors efficiently transmit the viruses is key to controlling the viral diseases. Autophagy commonly plays important roles in plant host defense against virus infection, but recent studies have shown that plant reoviruses can hijack the autophagy pathway in insect cells to enable their persistence in the insect and continued transmission to plants. Here, we summarize and discuss new insights on viral activation, evasion, regulation, and manipulation of autophagy within the insect vectors and the role of autophagy in virus survival in insect vectors. Deeper knowledge of the functions of autophagy in vectors may lead to novel strategies for blocking transmission of insect-borne plant viruses. a process that is triggered by signal molecules and occurs in multicellular when a cell ‘intentionally’ dies. a self-degradative process in cells by which damaged, aging, dysfunctional, or abnormal proteins and cellular components are encapsulated by the bilayer membrane of a vesicle and broken down for recycling. a spherical structure derived from the fusion between the outer membrane of the autophagosome and the membrane of a lysosome. a double-membraned cytosolic vesicle from which a phagophore extends outward to envelop components to be degraded. a single-membraned degradative organelle that contains various hydrolases that can break down many kinds of biomolecules. apoptotic cell death induced when mitochondria are damaged, dysfunctional, or their membrane has become depolarized. a selective autophagy that degrades damaged, dysfunctional, or excess mitochondria. a mode of virus transmission by insect vectors in which plant viruses are retained for long periods (days to weeks), often throughout the insect’s lifespan, and invade and replicate in various tissues of their vectors. isolation membrane (autophagosome precursor) that is derived from intracellular organelles including endoplasmic reticulum, Golgi apparatus, and plasma membrane form a cup-shaped structure with a bilayer membrane. a type of nonenveloped double-stranded RNA virus, first found in respiratory and enteric tissue. transmission by which microbes spread from parent to offspring through the reproductive organs or cells of insect vector. newly synthesized genome (nucleic acids) and proteins are combined into new virus particles. densely staining membraneless structures that are intricately involved in viral replication in virus-infected cells. vector insects that carry and transmit viruses." @default.
• W4384156585 created "2023-07-14" @default.
• W4384156585 creator A5009692658 @default.
• W4384156585 creator A5016795467 @default.
• W4384156585 creator A5086417626 @default.
• W4384156585 date "2023-07-01" @default.
• W4384156585 modified "2023-10-18" @default.
• W4384156585 title "Plant reoviruses hijack autophagy in insect vectors" @default.
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• W4384156585 doi "https://doi.org/10.1016/j.tim.2023.06.008" @default.
• W4384156585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37453843" @default.
• W4384156585 hasPublicationYear "2023" @default.
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• W4384156585 hasAuthorship W4384156585A5086417626 @default.

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