FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384156674> ?p ?o ?g. }

• W4384156674 abstract "Association of a high-fat diet with increased risks of cardiovascular disease (CVD) and type 2 diabetes, has prompted evaluation of lipids in people with CF (pwCF). However, most evidence on dyslipidemia was published before CF transmembrane conductance regulator (CFTR) modulators became a standard of care. The main goal of this study was to investigate the effect of CFTR modulator therapies on lipid and lipoprotein profiles in children and adolescents with CF.Blood samples were collected from 153 pwCF (10.1 ± 4.7 years of age) and 60 age-matched controls. Most pwCF were pancreatic insufficient on pancreatic enzyme replacement therapy. By the end of the study, 65% of CF participants were on CFTR modulator therapy for >1 month. The results of traditional and advanced lipid testing in pwCF were correlated with clinical and dietary information.Total cholesterol and low-density lipoprotein (LDL) cholesterol were significantly lower in pwCF compared to non-CF participants. Those not receiving CFTR modulators also had significantly lower high-density lipoprotein (HDL) cholesterol and HDL particle number than controls. Individuals with CF on modulator therapy had significantly higher concentrations of anti-atherogenic HDL cholesterol and HDL particles along with lower levels of atherogenic large very-low density lipoprotein (VLDL) particles, total and small LDL particles, and triglycerides compared to those without CFTR modulator therapy.CFTR modulator therapy has a beneficial effect on dyslipidemia in CF. It remains to be seen if these positive changes translate into decreased CVD risk later in life given the increasing life expectancy in CF." @default.
• W4384156674 created "2023-07-14" @default.
• W4384156674 creator A5001394426 @default.
• W4384156674 creator A5020582217 @default.
• W4384156674 creator A5047794303 @default.
• W4384156674 creator A5055867803 @default.
• W4384156674 creator A5056531003 @default.
• W4384156674 creator A5073780703 @default.
• W4384156674 creator A5083657707 @default.
• W4384156674 creator A5086474442 @default.
• W4384156674 date "2023-07-01" @default.
• W4384156674 modified "2023-10-14" @default.
• W4384156674 title "Improvement of lipid and lipoprotein profiles in children and adolescents with cystic fibrosis on CFTR modulator therapy" @default.
• W4384156674 cites W1605307665 @default.
• W4384156674 cites W1823098442 @default.
• W4384156674 cites W1899476920 @default.
• W4384156674 cites W1970963921 @default.
• W4384156674 cites W1982239584 @default.
• W4384156674 cites W1992018655 @default.
• W4384156674 cites W2012550788 @default.
• W4384156674 cites W2021193933 @default.
• W4384156674 cites W2028867762 @default.
• W4384156674 cites W2081338419 @default.
• W4384156674 cites W2085861288 @default.
• W4384156674 cites W2097119582 @default.
• W4384156674 cites W2114815887 @default.
• W4384156674 cites W2152066083 @default.
• W4384156674 cites W2582657518 @default.
• W4384156674 cites W2591923405 @default.
• W4384156674 cites W2620579455 @default.
• W4384156674 cites W2799413164 @default.
• W4384156674 cites W2805157317 @default.
• W4384156674 cites W2900581749 @default.
• W4384156674 cites W2938250902 @default.
• W4384156674 cites W2952212183 @default.
• W4384156674 cites W3006116566 @default.
• W4384156674 cites W3008025512 @default.
• W4384156674 cites W3016400031 @default.
• W4384156674 cites W3024297516 @default.
• W4384156674 cites W3028054426 @default.
• W4384156674 cites W3036770040 @default.
• W4384156674 cites W3080140269 @default.
• W4384156674 cites W3085465371 @default.
• W4384156674 cites W3118643798 @default.
• W4384156674 cites W3127562344 @default.
• W4384156674 cites W3207443835 @default.
• W4384156674 cites W3208672428 @default.
• W4384156674 cites W3216867558 @default.
• W4384156674 cites W4221055210 @default.
• W4384156674 cites W4309728740 @default.
• W4384156674 cites W4312179122 @default.
• W4384156674 doi "https://doi.org/10.1016/j.jcf.2023.07.001" @default.
• W4384156674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37453889" @default.
• W4384156674 hasPublicationYear "2023" @default.
• W4384156674 type Work @default.
• W4384156674 citedByCount "1" @default.
• W4384156674 countsByYear W43841566742023 @default.
• W4384156674 crossrefType "journal-article" @default.
• W4384156674 hasAuthorship W4384156674A5001394426 @default.
• W4384156674 hasAuthorship W4384156674A5020582217 @default.
• W4384156674 hasAuthorship W4384156674A5047794303 @default.
• W4384156674 hasAuthorship W4384156674A5055867803 @default.
• W4384156674 hasAuthorship W4384156674A5056531003 @default.
• W4384156674 hasAuthorship W4384156674A5073780703 @default.
• W4384156674 hasAuthorship W4384156674A5083657707 @default.
• W4384156674 hasAuthorship W4384156674A5086474442 @default.
• W4384156674 hasConcept C126322002 @default.
• W4384156674 hasConcept C134018914 @default.
• W4384156674 hasConcept C2776938444 @default.
• W4384156674 hasConcept C2778096610 @default.
• W4384156674 hasConcept C2778163477 @default.
• W4384156674 hasConcept C2778428886 @default.
• W4384156674 hasConcept C2778913445 @default.
• W4384156674 hasConcept C2780072125 @default.
• W4384156674 hasConcept C555293320 @default.
• W4384156674 hasConcept C71924100 @default.
• W4384156674 hasConcept C8243546 @default.
• W4384156674 hasConceptScore W4384156674C126322002 @default.
• W4384156674 hasConceptScore W4384156674C134018914 @default.
• W4384156674 hasConceptScore W4384156674C2776938444 @default.
• W4384156674 hasConceptScore W4384156674C2778096610 @default.
• W4384156674 hasConceptScore W4384156674C2778163477 @default.
• W4384156674 hasConceptScore W4384156674C2778428886 @default.
• W4384156674 hasConceptScore W4384156674C2778913445 @default.
• W4384156674 hasConceptScore W4384156674C2780072125 @default.
• W4384156674 hasConceptScore W4384156674C555293320 @default.
• W4384156674 hasConceptScore W4384156674C71924100 @default.
• W4384156674 hasConceptScore W4384156674C8243546 @default.
• W4384156674 hasLocation W43841566741 @default.
• W4384156674 hasLocation W43841566742 @default.
• W4384156674 hasOpenAccess W4384156674 @default.
• W4384156674 hasPrimaryLocation W43841566741 @default.
• W4384156674 hasRelatedWork W1976602105 @default.
• W4384156674 hasRelatedWork W2040092002 @default.
• W4384156674 hasRelatedWork W2072276648 @default.
• W4384156674 hasRelatedWork W2130678710 @default.
• W4384156674 hasRelatedWork W2134715975 @default.
• W4384156674 hasRelatedWork W2157000830 @default.
• W4384156674 hasRelatedWork W2157155183 @default.
• W4384156674 hasRelatedWork W2318646559 @default.

• next