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- W4384156679 endingPage "104703" @default.
- W4384156679 startingPage "104703" @default.
- W4384156679 abstract "The design and development of lanthanide-based theranostic nanoplatforms, owing to unique physiochemical properties have attracted significant interest in enhancing the diagnostic and therapeutic efficiency against cancer. In this study, hollow Nd-doped Gd2O3 (H-NdxGd2-xO3) nanostructures were synthesized through the scarified template strategy. Qualitative and quantitative X-ray analysis confirmed the substitution of Nd3+ ions by Gd3+ ions in the cubic structure of pristine H–Gd2O3 nanostructure. Polyethylene glycol (PEG) successfully decorated the surface of the as-synthesized nanostructure to reduce the inherent toxicity. H-NdxGd2-xO3@PEG nanoplatforms showed a significant DOX adsorption capacity (149.5 mg/g). Biocompatible H-NdxGd2-xO3@PEG nanoplatforms showed a considerable response to the simulated tumor microenvironment (TME) of cancer. The characteristic features of simulated TME of cancer not only enhance the drug release efficiency (72%), but also reinforced the T1-weighted MRI signal (19.33 mM−1. S−1), and CT signal (247 HU)." @default.
- W4384156679 created "2023-07-14" @default.
- W4384156679 creator A5003076233 @default.
- W4384156679 creator A5015578124 @default.
- W4384156679 creator A5083821545 @default.
- W4384156679 creator A5086830790 @default.
- W4384156679 date "2023-09-01" @default.
- W4384156679 modified "2023-09-25" @default.
- W4384156679 title "Development of lanthanide-based “all in one” theranostic nanoplatforms for TME-reinforced T1-weighted MRI/CT bimodal imaging" @default.
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