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- W4384156950 abstract "Biologists have known for decades that certain cells die at specific times during the development of multicellular organisms, and such events contribute to morphogenesis. However, the underlying circuitries remained a mystery until the 1980s when a small network of genes that regulate the 131 developmental somatic cell deaths (“programmed cell death”) in the hermaphrodite of the round worm Caenorhabditis elegans was identified (reviewed in [ [1] Del Re D.P. Amgalan D. Linkermann A. Liu Q. Kitsis R.N. Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol. Rev. 2019; 99: 1765-1817https://doi.org/10.1152/physrev.00022.2018 Crossref PubMed Scopus (387) Google Scholar ]). These observations provided the first mechanistic evidence for the concept that cell death can be an actively-mediated and regulated process as opposed to merely a passive consequence of damage to cellular components." @default.
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- W4384156950 date "2023-09-01" @default.
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- W4384156950 title "Introduction to review series: Regulated necrosis programs in heart disease" @default.
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- W4384156950 doi "https://doi.org/10.1016/j.yjmcc.2023.07.003" @default.
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