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- W4384157038 abstract "In the current study, the solubility of famotidine (FAM) in supercritical carbon dioxide (scCO₂) was experimentally determined for the first time. The FAM solubility in scCO₂, expressed as mole fraction, at different temperatures (308−338 K) and pressures (12−30 MPa) was found to be in the range of 1.40×10−6 to 1.11×10−4. Due to the low solubility of FAM in scCO₂, the gas anti-solvent and supercritical anti-solvent processes can be a good option to generate the nano/micro size particles of this drug. The experimental solubility data were correlated by the density-based models of Bartle et al., Méndez-Santiago and Teja (MST), Jouyban et al. and Hozhabr et al., by the non-cubic equation of state PC-SAFT, and by the two versions of the Estévez et al. model (ECM-PR and ECM-RK). According to the modeling results, the Estévez et al. model showed the highest accuracy with AARD values of 9.92 (ECM-PR) and 10.70 (ECM-RK). The empirical models also yielded satisfactory outcomes to the correlation of the solubility of FAM in scCO₂." @default.
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- W4384157038 date "2023-10-01" @default.
- W4384157038 modified "2023-09-27" @default.
- W4384157038 title "Solubility of famotidine in supercritical carbon dioxide: Experimental measurement and thermodynamic modeling" @default.
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- W4384157038 doi "https://doi.org/10.1016/j.supflu.2023.106031" @default.
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