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- W4384157047 abstract "Designer nucleic acid-based drugs in the form of pills are proclaimed to be the favored choice of both clinicians and patients. In article number 2300022, Hiroshi Sugiyama, Ganesh N. Pandian, and Vaijayanthi Thangavel review an advanced, therapeutic gene regulation strategy based on designer pyrrole-imidazole polyamides (PIP) that can be pre-programmed to recognize specific sequences in the minor groove of nuclear and mitochondrial DNA. This review summarizes the recent progress of designer PIPs with versatile functions as the front-runner of nucleic acid-based small molecule drugs in the race from the bench side to the clinic because of their demonstrated potential in treating cancers and several intractable diseases." @default.
- W4384157047 created "2023-07-14" @default.
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- W4384157047 date "2023-07-01" @default.
- W4384157047 modified "2023-10-17" @default.
- W4384157047 title "Pyrrole–Imidazole Polyamides – A Frontrunner in Nucleic Acid‐Based Small Molecule Drugs (Adv. Therap. 7/2023)" @default.
- W4384157047 doi "https://doi.org/10.1002/adtp.202370018" @default.
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