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- W4384161762 abstract "Adhesion to living and non-living surfaces is an important virulence trait of the fungal pathogen Candida albicans . Biofilm formation in this organism depends on the expression of a number of cell surface proteins including the hypha-specific protein Als3p. Loss of ALS3 impairs biofilm formation and decreases cell-cell adhesion. We wanted to test whether constitutively expressing ALS3 could compensate for defects in adhesion and biofilm formation observed in mutant strains that lack key transcriptional regulators of biofilm formation Efg1p and Cph1p. We found that ALS3 improved adhesion and biofilm formation in the efg1 Δ and efg1 Δ cph1 Δ mutant strains, but had less effect on the cph1 Δ strain." @default.
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- W4384161762 date "2023-07-13" @default.
- W4384161762 modified "2023-10-18" @default.
- W4384161762 title "Constitutive ALS3 expression in Candida albicans enhances adhesion and biofilm formation of efg1, but not cph1 mutant strains" @default.
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- W4384161762 doi "https://doi.org/10.1371/journal.pone.0286547" @default.
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