Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384161862> ?p ?o ?g. }
- W4384161862 endingPage "122561" @default.
- W4384161862 startingPage "122561" @default.
- W4384161862 abstract "A one-pot method was employed for the preparation of zinc and copper complexes of 4-methoxyphenyl-2,6-di(pyrazine-2-yl)pyridine ligand (L). The complexes were designed to acknowledge their potential as selective binders with serum albumins. The reaction of the metal chlorides with an excess of ligand L yielded mononuclear [CuL2]Cl2 (1) and [ZnL2]Cl2 (2) complexes. 1H NMR, UV-Vis spectroscopy, ESR, HRMS, XRD, and elemental analysis were carried out to characterize the complexes. The interactions of the synthesized complexes with Human Serum Albumin (HSA) and their drug displacement properties using ibuprofen and warfarin were investigated with the help of spectroscopic as well as molecular modeling techniques. Complex 1 exhibited better binding capability, indicated by its binding constant value (31.2 x104 M-1) towards HSA, than complex 2 (5.6 x104 M-1), as depicted from UV-Visible and fluorescence spectroscopic studies. Moreover, the complexes showed better binding affinity towards HSA than the corresponding free ligand (0.2 x104 M-1). The mechanism through which fluorescence quenching of HSA takes place (when metal complexes 1-2 were added to it) is static in nature. The Stern-Volmer (SV) equation was utilized to deduce the binding constants (Kb) through a fluorescence titration method. Moreover, structure optimization of the synthesized complexes and theoretical studies using density functional theory (DFT) has been carried out to determine the nature of the interaction of the complexes with the biomolecules." @default.
- W4384161862 created "2023-07-14" @default.
- W4384161862 creator A5003992365 @default.
- W4384161862 creator A5029311934 @default.
- W4384161862 creator A5031930023 @default.
- W4384161862 creator A5042742823 @default.
- W4384161862 creator A5045721248 @default.
- W4384161862 creator A5050023497 @default.
- W4384161862 creator A5061029699 @default.
- W4384161862 creator A5082064131 @default.
- W4384161862 date "2023-10-01" @default.
- W4384161862 modified "2023-09-30" @default.
- W4384161862 title "Protein interactions and drug displacement studies of novel copper(II) and zinc(II) complexes of a dipyrazinylpyridine ligand" @default.
- W4384161862 cites W1227031960 @default.
- W4384161862 cites W1516858556 @default.
- W4384161862 cites W1971428441 @default.
- W4384161862 cites W1987269510 @default.
- W4384161862 cites W1990583552 @default.
- W4384161862 cites W1997689921 @default.
- W4384161862 cites W2002815709 @default.
- W4384161862 cites W2004050537 @default.
- W4384161862 cites W2014950975 @default.
- W4384161862 cites W2016401253 @default.
- W4384161862 cites W2018421404 @default.
- W4384161862 cites W2023271988 @default.
- W4384161862 cites W2026789919 @default.
- W4384161862 cites W2029136818 @default.
- W4384161862 cites W2029639743 @default.
- W4384161862 cites W2030730924 @default.
- W4384161862 cites W2035884057 @default.
- W4384161862 cites W2036098386 @default.
- W4384161862 cites W2040184556 @default.
- W4384161862 cites W2051948432 @default.
- W4384161862 cites W2055744129 @default.
- W4384161862 cites W2056677038 @default.
- W4384161862 cites W2060540813 @default.
- W4384161862 cites W2069243241 @default.
- W4384161862 cites W2078134860 @default.
- W4384161862 cites W2079727759 @default.
- W4384161862 cites W2084687677 @default.
- W4384161862 cites W2084938226 @default.
- W4384161862 cites W2086382728 @default.
- W4384161862 cites W2086455617 @default.
- W4384161862 cites W2090328743 @default.
- W4384161862 cites W2104571730 @default.
- W4384161862 cites W2122333195 @default.
- W4384161862 cites W2152604288 @default.
- W4384161862 cites W2312813816 @default.
- W4384161862 cites W2318499983 @default.
- W4384161862 cites W2321972685 @default.
- W4384161862 cites W2323780936 @default.
- W4384161862 cites W2324749415 @default.
- W4384161862 cites W2331405994 @default.
- W4384161862 cites W2344445259 @default.
- W4384161862 cites W2467010047 @default.
- W4384161862 cites W2537536133 @default.
- W4384161862 cites W2600153891 @default.
- W4384161862 cites W2687982230 @default.
- W4384161862 cites W2736349954 @default.
- W4384161862 cites W2794148927 @default.
- W4384161862 cites W2888132248 @default.
- W4384161862 cites W2943893168 @default.
- W4384161862 cites W2953246153 @default.
- W4384161862 cites W2961621303 @default.
- W4384161862 cites W2973012670 @default.
- W4384161862 cites W3008063732 @default.
- W4384161862 cites W3008722627 @default.
- W4384161862 cites W3015353099 @default.
- W4384161862 cites W3150198942 @default.
- W4384161862 cites W3169307621 @default.
- W4384161862 cites W3173849638 @default.
- W4384161862 cites W3186215972 @default.
- W4384161862 cites W3203621981 @default.
- W4384161862 cites W3211677758 @default.
- W4384161862 cites W3211975584 @default.
- W4384161862 cites W4280588950 @default.
- W4384161862 cites W4281678398 @default.
- W4384161862 cites W4281777176 @default.
- W4384161862 cites W4283024439 @default.
- W4384161862 cites W4300716382 @default.
- W4384161862 cites W4317751674 @default.
- W4384161862 doi "https://doi.org/10.1016/j.molliq.2023.122561" @default.
- W4384161862 hasPublicationYear "2023" @default.
- W4384161862 type Work @default.
- W4384161862 citedByCount "0" @default.
- W4384161862 crossrefType "journal-article" @default.
- W4384161862 hasAuthorship W4384161862A5003992365 @default.
- W4384161862 hasAuthorship W4384161862A5029311934 @default.
- W4384161862 hasAuthorship W4384161862A5031930023 @default.
- W4384161862 hasAuthorship W4384161862A5042742823 @default.
- W4384161862 hasAuthorship W4384161862A5045721248 @default.
- W4384161862 hasAuthorship W4384161862A5050023497 @default.
- W4384161862 hasAuthorship W4384161862A5061029699 @default.
- W4384161862 hasAuthorship W4384161862A5082064131 @default.
- W4384161862 hasConcept C107824862 @default.
- W4384161862 hasConcept C116569031 @default.
- W4384161862 hasConcept C121332964 @default.
- W4384161862 hasConcept C121745418 @default.