FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384161925> ?p ?o ?g. }

• W4384161925 endingPage "e0287483" @default.
• W4384161925 startingPage "e0287483" @default.
• W4384161925 abstract "The problem of aligning multiple biological sequences has fascinated scientists for a long time. Over the last four decades, tens of heuristic-based Multiple Sequence Alignment (MSA) tools have been proposed, the vast majority being built on the concept of Progressive Alignment. It is known, however, that this approach suffers from an inherent drawback regarding the inadvertent insertion of gaps when aligning sequences. Two well-known corrective solutions have frequently been adopted to help mitigate this: Consistency Transformation and Iterative Refinement. This paper takes a tool-independent technique-oriented look at the alignment quality benefits of these two strategies using problem instances from the HOMSTRAD and BAliBASE benchmarks. Eighty MSA aligners have been used to compare 4 classes of heuristics: Progressive Alignments, Iterative Alignments, Consistency-based Alignments, and Consistency-based Progressive Alignments with Iterative Refinement. Statistically, while both Consistency-based classes are better for alignments with low similarity, for sequences with higher similarity, the differences between the classes are less clear. Iterative Refinement has its own drawbacks resulting in there being statistically little advantage for Progressive Aligners to adopt this technique either with Consistency Transformation or without. Nevertheless, all 4 classes are capable of bettering each other, depending on the instance problem. This further motivates the development of MSA frameworks, such as the one being developed for this research, which simultaneously contemplate multiple classes and techniques in their attempt to uncover better solutions." @default.
• W4384161925 created "2023-07-14" @default.
• W4384161925 creator A5010320276 @default.
• W4384161925 creator A5020577476 @default.
• W4384161925 creator A5035747731 @default.
• W4384161925 date "2023-07-13" @default.
• W4384161925 modified "2023-09-26" @default.
• W4384161925 title "On closing the inopportune gap with consistency transformation and iterative refinement" @default.
• W4384161925 cites W1519266993 @default.
• W4384161925 cites W1527979595 @default.
• W4384161925 cites W1565582771 @default.
• W4384161925 cites W1969153299 @default.
• W4384161925 cites W1974326986 @default.
• W4384161925 cites W1988968244 @default.
• W4384161925 cites W1994101847 @default.
• W4384161925 cites W1995808589 @default.
• W4384161925 cites W2002638840 @default.
• W4384161925 cites W2004178884 @default.
• W4384161925 cites W2006290495 @default.
• W4384161925 cites W2015292449 @default.
• W4384161925 cites W2033339460 @default.
• W4384161925 cites W2033775040 @default.
• W4384161925 cites W2068083406 @default.
• W4384161925 cites W2072649575 @default.
• W4384161925 cites W2074231493 @default.
• W4384161925 cites W2080150416 @default.
• W4384161925 cites W2084052949 @default.
• W4384161925 cites W2088156508 @default.
• W4384161925 cites W2092672051 @default.
• W4384161925 cites W2097706568 @default.
• W4384161925 cites W2101220662 @default.
• W4384161925 cites W2102245393 @default.
• W4384161925 cites W2102502076 @default.
• W4384161925 cites W2106882534 @default.
• W4384161925 cites W2108215151 @default.
• W4384161925 cites W2119362018 @default.
• W4384161925 cites W2120636855 @default.
• W4384161925 cites W2126332379 @default.
• W4384161925 cites W2127322768 @default.
• W4384161925 cites W2127774996 @default.
• W4384161925 cites W2128613007 @default.
• W4384161925 cites W2136570298 @default.
• W4384161925 cites W2140872496 @default.
• W4384161925 cites W2143210482 @default.
• W4384161925 cites W2144362290 @default.
• W4384161925 cites W2147526198 @default.
• W4384161925 cites W2151831732 @default.
• W4384161925 cites W2152688507 @default.
• W4384161925 cites W2159638180 @default.
• W4384161925 cites W2165654401 @default.
• W4384161925 cites W2404726970 @default.
• W4384161925 cites W2911458886 @default.
• W4384161925 cites W2984761660 @default.
• W4384161925 cites W3012079654 @default.
• W4384161925 cites W4238424869 @default.
• W4384161925 cites W4252684946 @default.
• W4384161925 cites W4289827990 @default.
• W4384161925 doi "https://doi.org/10.1371/journal.pone.0287483" @default.
• W4384161925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37440507" @default.
• W4384161925 hasPublicationYear "2023" @default.
• W4384161925 type Work @default.
• W4384161925 citedByCount "0" @default.
• W4384161925 crossrefType "journal-article" @default.
• W4384161925 hasAuthorship W4384161925A5010320276 @default.
• W4384161925 hasAuthorship W4384161925A5020577476 @default.
• W4384161925 hasAuthorship W4384161925A5035747731 @default.
• W4384161925 hasBestOaLocation W43841619251 @default.
• W4384161925 hasConcept C103278499 @default.
• W4384161925 hasConcept C104317684 @default.
• W4384161925 hasConcept C111919701 @default.
• W4384161925 hasConcept C11413529 @default.
• W4384161925 hasConcept C115903868 @default.
• W4384161925 hasConcept C115961682 @default.
• W4384161925 hasConcept C124101348 @default.
• W4384161925 hasConcept C127705205 @default.
• W4384161925 hasConcept C143587482 @default.
• W4384161925 hasConcept C154945302 @default.
• W4384161925 hasConcept C159694833 @default.
• W4384161925 hasConcept C167625842 @default.
• W4384161925 hasConcept C173801870 @default.
• W4384161925 hasConcept C185592680 @default.
• W4384161925 hasConcept C204241405 @default.
• W4384161925 hasConcept C2776436953 @default.
• W4384161925 hasConcept C2778112365 @default.
• W4384161925 hasConcept C2779982483 @default.
• W4384161925 hasConcept C41008148 @default.
• W4384161925 hasConcept C45484198 @default.
• W4384161925 hasConcept C54355233 @default.
• W4384161925 hasConcept C55493867 @default.
• W4384161925 hasConcept C86803240 @default.
• W4384161925 hasConcept C88031987 @default.
• W4384161925 hasConceptScore W4384161925C103278499 @default.
• W4384161925 hasConceptScore W4384161925C104317684 @default.
• W4384161925 hasConceptScore W4384161925C111919701 @default.
• W4384161925 hasConceptScore W4384161925C11413529 @default.
• W4384161925 hasConceptScore W4384161925C115903868 @default.
• W4384161925 hasConceptScore W4384161925C115961682 @default.
• W4384161925 hasConceptScore W4384161925C124101348 @default.

• next