FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384162953> ?p ?o ?g. }

• W4384162953 endingPage "156289" @default.
• W4384162953 startingPage "156289" @default.
• W4384162953 abstract "The development of diffuse large B-cell lymphoma (DLBCL), a prevalent subgroup of non-Hodgkin lymphoma (NHL), potentially involves various cytokines. We aimed to determine the correlation between deregulated serum levels of cytokines and clinical features and investigate their impact on the prognosis of patients with DLBCL.We conducted a retrospective study of 77 patients with newly diagnosed DLBCL to explore the relationships between different cytokines, adverse clinical features, and poor outcomes. The Mann-Whitney U test was used to compare the cytokine profiles between patients with DLBCL and healthy controls. The Kaplan-Meier method was used to analyze the probability of survival, and the log-rank tests were used to evaluate the differences between survival curves. The Cox proportional hazards regression model was used to performed univariate and multivariate analyses to evaluate prognostic variables for survival analyze.Serum levels of interleukin-2 (IL-2), tumor necrosis factor (TNF)-α, IL-6, IL-10, and IFN-γ were significantly elevated in patients with untreated DLBCL. Serum levels of IL-6 and IL-10 were significantly higher in patients with an International Prognostic Index (IPI) of 3-5, bone marrow involvement, serum levels of LDH ≥ 250 U/L, and β2-microglobulin (β2-MG) levels ≥ 2.3 mg/L. Patients with B symptoms only had higher serum IL-10 levels, whereas patients with a partial response or no response to treatment had significantly elevated serum levels of IL-6 as well as IL-10. Significant positive correlations were observed between the levels of IL-6 and IL-10 with those of β2-MG and LDH. Patients with levels of IL-6 ≥ 4.5 or IL-10 ≥ 5.0 pg/mL, as well as combined elevated IL-6 and IL-10 levels, exhibited shorter progression-free survival and overall survival. Additionally, univariate and multivariate analyses revealed that serum levels of IL-6 ≥ 4.5 pg/mL and IL-10 ≥ 5.0 pg/mL and IPI 3-5 were independent prognostic factors for relapse and survival in patients with DLBCL.Pre-treatment serum IL-6 and IL-10 levels in patients with newly diagnosed DLBCL might be powerful markers for determining treatment response and predicting the prognosis of DLBCL." @default.
• W4384162953 created "2023-07-14" @default.
• W4384162953 creator A5000239300 @default.
• W4384162953 creator A5010219161 @default.
• W4384162953 creator A5025298235 @default.
• W4384162953 creator A5036109498 @default.
• W4384162953 creator A5057917536 @default.
• W4384162953 creator A5081562864 @default.
• W4384162953 date "2023-09-01" @default.
• W4384162953 modified "2023-10-16" @default.
• W4384162953 title "Cytokine profiles in patients with newly diagnosed diffuse large B-cell lymphoma: IL-6 and IL-10 levels are associated with adverse clinical features and poor outcomes" @default.
• W4384162953 cites W1602943807 @default.
• W4384162953 cites W1971523115 @default.
• W4384162953 cites W1976678451 @default.
• W4384162953 cites W1979358785 @default.
• W4384162953 cites W1988529669 @default.
• W4384162953 cites W2005032298 @default.
• W4384162953 cites W2018071905 @default.
• W4384162953 cites W2027749164 @default.
• W4384162953 cites W2040893174 @default.
• W4384162953 cites W2041537699 @default.
• W4384162953 cites W2063691874 @default.
• W4384162953 cites W2072351874 @default.
• W4384162953 cites W2078081644 @default.
• W4384162953 cites W2079054460 @default.
• W4384162953 cites W2081236044 @default.
• W4384162953 cites W2125451332 @default.
• W4384162953 cites W2161074777 @default.
• W4384162953 cites W2162212325 @default.
• W4384162953 cites W2166461774 @default.
• W4384162953 cites W2326248932 @default.
• W4384162953 cites W2412356789 @default.
• W4384162953 cites W2413482995 @default.
• W4384162953 cites W2527144451 @default.
• W4384162953 cites W2614308869 @default.
• W4384162953 cites W2744261860 @default.
• W4384162953 cites W2790385595 @default.
• W4384162953 cites W2921259899 @default.
• W4384162953 cites W2948816402 @default.
• W4384162953 cites W2972610453 @default.
• W4384162953 cites W2993168114 @default.
• W4384162953 cites W3004474173 @default.
• W4384162953 cites W3099114602 @default.
• W4384162953 cites W3215525273 @default.
• W4384162953 cites W4205736005 @default.
• W4384162953 cites W4292553315 @default.
• W4384162953 doi "https://doi.org/10.1016/j.cyto.2023.156289" @default.
• W4384162953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37453327" @default.
• W4384162953 hasPublicationYear "2023" @default.
• W4384162953 type Work @default.
• W4384162953 citedByCount "0" @default.
• W4384162953 crossrefType "journal-article" @default.
• W4384162953 hasAuthorship W4384162953A5000239300 @default.
• W4384162953 hasAuthorship W4384162953A5010219161 @default.
• W4384162953 hasAuthorship W4384162953A5025298235 @default.
• W4384162953 hasAuthorship W4384162953A5036109498 @default.
• W4384162953 hasAuthorship W4384162953A5057917536 @default.
• W4384162953 hasAuthorship W4384162953A5081562864 @default.
• W4384162953 hasBestOaLocation W43841629531 @default.
• W4384162953 hasConcept C10515644 @default.
• W4384162953 hasConcept C126322002 @default.
• W4384162953 hasConcept C143998085 @default.
• W4384162953 hasConcept C144301174 @default.
• W4384162953 hasConcept C21957315 @default.
• W4384162953 hasConcept C2778476033 @default.
• W4384162953 hasConcept C2778559949 @default.
• W4384162953 hasConcept C2778690821 @default.
• W4384162953 hasConcept C2779338263 @default.
• W4384162953 hasConcept C2779714933 @default.
• W4384162953 hasConcept C38180746 @default.
• W4384162953 hasConcept C50382708 @default.
• W4384162953 hasConcept C71924100 @default.
• W4384162953 hasConcept C74172505 @default.
• W4384162953 hasConcept C90924648 @default.
• W4384162953 hasConceptScore W4384162953C10515644 @default.
• W4384162953 hasConceptScore W4384162953C126322002 @default.
• W4384162953 hasConceptScore W4384162953C143998085 @default.
• W4384162953 hasConceptScore W4384162953C144301174 @default.
• W4384162953 hasConceptScore W4384162953C21957315 @default.
• W4384162953 hasConceptScore W4384162953C2778476033 @default.
• W4384162953 hasConceptScore W4384162953C2778559949 @default.
• W4384162953 hasConceptScore W4384162953C2778690821 @default.
• W4384162953 hasConceptScore W4384162953C2779338263 @default.
• W4384162953 hasConceptScore W4384162953C2779714933 @default.
• W4384162953 hasConceptScore W4384162953C38180746 @default.
• W4384162953 hasConceptScore W4384162953C50382708 @default.
• W4384162953 hasConceptScore W4384162953C71924100 @default.
• W4384162953 hasConceptScore W4384162953C74172505 @default.
• W4384162953 hasConceptScore W4384162953C90924648 @default.
• W4384162953 hasLocation W43841629531 @default.
• W4384162953 hasLocation W43841629532 @default.
• W4384162953 hasOpenAccess W4384162953 @default.
• W4384162953 hasPrimaryLocation W43841629531 @default.
• W4384162953 hasRelatedWork W2069813709 @default.
• W4384162953 hasRelatedWork W2361700749 @default.
• W4384162953 hasRelatedWork W2386134303 @default.
• W4384162953 hasRelatedWork W2386721966 @default.
• W4384162953 hasRelatedWork W2413742967 @default.

• next