Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384197624> ?p ?o ?g. }
- W4384197624 abstract "Currently, microsatellite high instability (MSI-H)/mismatch repair protein deletion (dMMR) has become a crucial biomarker for utilizing immune checkpoint inhibitors in patients with advanced colorectal cancer (mCRC). However, the proportion of MSI-H/dMMR in advanced patients is only about 5% and mCRC patients with microsatellite stability (MSS)/proficient mismatch repair (pMMR) exhibit poor responses to immunotherapy. Although diverse immune combination therapy regimens have been examined in patients with advanced colorectal cancer who demonstrate MSS/pMMR, these approaches have not yielded favorable efficacy and only a limited proportion of patients have benefited, especially for advanced colorectal cancer patients with liver metastases. Therefore, the mechanism of benefit and potential biomarkers of immunotherapy in patients with MSS/pMMR mCRC deserve more in-depth exploration. Here, we present a case study of a rectal cancer patient with MSS and PD-L1-negative recurrent hepatopulmonary metastases who attained complete remission (CR) and sustained benefits with immunotherapy after systemic therapy had failed. The analysis of the patient’s genetic and immune microenvironmental characteristics revealed that mutations in DNA damage repair (DDR) pathway genes and the existence of abundant tumor-infiltrating lymphocytes could contribute to his potential benefit." @default.
- W4384197624 created "2023-07-14" @default.
- W4384197624 creator A5004692777 @default.
- W4384197624 creator A5007825172 @default.
- W4384197624 creator A5017825677 @default.
- W4384197624 creator A5045415662 @default.
- W4384197624 creator A5054014646 @default.
- W4384197624 creator A5058554811 @default.
- W4384197624 creator A5069084441 @default.
- W4384197624 creator A5083567474 @default.
- W4384197624 date "2023-07-13" @default.
- W4384197624 modified "2023-09-25" @default.
- W4384197624 title "Case Report: Genetic and immune microenvironmental characteristics of a rectal cancer patient with MSS/PD-L1-negative recurrent hepatopulmonary metastasis who achieved complete remission after treatment with PD-1 inhibitor" @default.
- W4384197624 cites W1940241680 @default.
- W4384197624 cites W2161691060 @default.
- W4384197624 cites W2344037260 @default.
- W4384197624 cites W2513200835 @default.
- W4384197624 cites W2587862832 @default.
- W4384197624 cites W2739132742 @default.
- W4384197624 cites W2789900268 @default.
- W4384197624 cites W2791328450 @default.
- W4384197624 cites W2802206159 @default.
- W4384197624 cites W2803558333 @default.
- W4384197624 cites W2893665301 @default.
- W4384197624 cites W2920863623 @default.
- W4384197624 cites W2966972050 @default.
- W4384197624 cites W2971912764 @default.
- W4384197624 cites W3020689019 @default.
- W4384197624 cites W3021442601 @default.
- W4384197624 cites W3024111792 @default.
- W4384197624 cites W3047018993 @default.
- W4384197624 cites W3092226358 @default.
- W4384197624 cites W3131014490 @default.
- W4384197624 cites W3143513922 @default.
- W4384197624 cites W3175350156 @default.
- W4384197624 cites W3187790888 @default.
- W4384197624 cites W3191878364 @default.
- W4384197624 cites W3197648290 @default.
- W4384197624 cites W3198284808 @default.
- W4384197624 cites W4210596686 @default.
- W4384197624 cites W4247073213 @default.
- W4384197624 cites W4281788801 @default.
- W4384197624 cites W4294124568 @default.
- W4384197624 cites W4362458137 @default.
- W4384197624 doi "https://doi.org/10.3389/fimmu.2023.1197543" @default.
- W4384197624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37520536" @default.
- W4384197624 hasPublicationYear "2023" @default.
- W4384197624 type Work @default.
- W4384197624 citedByCount "0" @default.
- W4384197624 crossrefType "journal-article" @default.
- W4384197624 hasAuthorship W4384197624A5004692777 @default.
- W4384197624 hasAuthorship W4384197624A5007825172 @default.
- W4384197624 hasAuthorship W4384197624A5017825677 @default.
- W4384197624 hasAuthorship W4384197624A5045415662 @default.
- W4384197624 hasAuthorship W4384197624A5054014646 @default.
- W4384197624 hasAuthorship W4384197624A5058554811 @default.
- W4384197624 hasAuthorship W4384197624A5069084441 @default.
- W4384197624 hasAuthorship W4384197624A5083567474 @default.
- W4384197624 hasBestOaLocation W43841976241 @default.
- W4384197624 hasConcept C104317684 @default.
- W4384197624 hasConcept C121608353 @default.
- W4384197624 hasConcept C126322002 @default.
- W4384197624 hasConcept C143998085 @default.
- W4384197624 hasConcept C180754005 @default.
- W4384197624 hasConcept C203014093 @default.
- W4384197624 hasConcept C2777701055 @default.
- W4384197624 hasConcept C2779013556 @default.
- W4384197624 hasConcept C2779767149 @default.
- W4384197624 hasConcept C2780851360 @default.
- W4384197624 hasConcept C502942594 @default.
- W4384197624 hasConcept C526805850 @default.
- W4384197624 hasConcept C55493867 @default.
- W4384197624 hasConcept C60748783 @default.
- W4384197624 hasConcept C61320498 @default.
- W4384197624 hasConcept C71924100 @default.
- W4384197624 hasConcept C86803240 @default.
- W4384197624 hasConcept C8891405 @default.
- W4384197624 hasConceptScore W4384197624C104317684 @default.
- W4384197624 hasConceptScore W4384197624C121608353 @default.
- W4384197624 hasConceptScore W4384197624C126322002 @default.
- W4384197624 hasConceptScore W4384197624C143998085 @default.
- W4384197624 hasConceptScore W4384197624C180754005 @default.
- W4384197624 hasConceptScore W4384197624C203014093 @default.
- W4384197624 hasConceptScore W4384197624C2777701055 @default.
- W4384197624 hasConceptScore W4384197624C2779013556 @default.
- W4384197624 hasConceptScore W4384197624C2779767149 @default.
- W4384197624 hasConceptScore W4384197624C2780851360 @default.
- W4384197624 hasConceptScore W4384197624C502942594 @default.
- W4384197624 hasConceptScore W4384197624C526805850 @default.
- W4384197624 hasConceptScore W4384197624C55493867 @default.
- W4384197624 hasConceptScore W4384197624C60748783 @default.
- W4384197624 hasConceptScore W4384197624C61320498 @default.
- W4384197624 hasConceptScore W4384197624C71924100 @default.
- W4384197624 hasConceptScore W4384197624C86803240 @default.
- W4384197624 hasConceptScore W4384197624C8891405 @default.
- W4384197624 hasLocation W43841976241 @default.
- W4384197624 hasLocation W43841976242 @default.
- W4384197624 hasLocation W43841976243 @default.
- W4384197624 hasOpenAccess W4384197624 @default.
- W4384197624 hasPrimaryLocation W43841976241 @default.