FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384200549> ?p ?o ?g. }

• W4384200549 abstract "Alteration in endothelial function during sepsis is thought to play a key role in the progression of organ failure. We herein compared plasma concentrations of endothelial activation biomarkers vascular endothelial growth factor (VEGF), hyaluronan (HA), plasminogen activator inhibitor-1 (PAI-1) and von Willebrand factor (vWF), as well as inflammatory mediator concentrations (IL-6, IL-8, IL-10, C-reactive protein and monocyte chemoattractant protein-1) in dogs with sepsis to healthy dogs.This study was a multicenter observational clinical trial conducted at two university teaching hospitals from February 2016 until July 2017. The study included 18 client-owned dogs hospitalized with sepsis and at least one distant organ dysfunction, as well as 20 healthy dogs. Plasma biomarker concentrations were measured using ELISA. Severity of illness in dogs with sepsis was calculated using the 5-variable acute physiologic and laboratory evaluation (APPLEFAST) score. Biomarker concentrations were compared between septic and healthy dogs using linear models.Septic peritonitis was the most frequent source of sepsis (11/18; 61%), followed by pneumonia (4/18; 22%). Ten dogs (56%) had only 1 organ dysfunction, whereas 3 dogs (17%) had 2, 3 (17%) had 3, 1 (6%) had 4 and 1 (6%) had 5 organ dysfunctions. The median APPLEFAST score in the septic dogs was 28.5 (Q1-Q3, 24-31). Mean plasma concentrations of all endothelial and inflammatory biomarkers, except vWF, were higher in the sepsis cohort than in controls. The mean endothelial biomarker concentrations in the septic cohort ranged from ~2.7-fold higher for HA (difference in means; 118.2 ng/mL, 95% credible limit; 44.5-221.7) to ~150-fold for VEGF (difference in means; 76.6 pg./mL, 95% credible limit; 33.0-143.4), compared to the healthy cohort. Fifteen dogs with sepsis (83%) died; 7 (46%) were euthanized and 8 (53%) died during hospitalization.Dogs with naturally occurring sepsis and organ dysfunction had higher mean concentrations of biomarkers of endothelial activation and inflammation compared to healthy dogs, broadening our understanding of the pathophysiology of sepsis secondary to endothelial dysfunction." @default.
• W4384200549 created "2023-07-14" @default.
• W4384200549 creator A5000553473 @default.
• W4384200549 creator A5003819014 @default.
• W4384200549 creator A5033470942 @default.
• W4384200549 creator A5034786904 @default.
• W4384200549 creator A5035783588 @default.
• W4384200549 creator A5041872862 @default.
• W4384200549 creator A5043956829 @default.
• W4384200549 creator A5052192959 @default.
• W4384200549 creator A5083699814 @default.
• W4384200549 date "2023-07-13" @default.
• W4384200549 modified "2023-09-29" @default.
• W4384200549 title "Biomarkers of endothelial activation and inflammation in dogs with organ dysfunction secondary to sepsis" @default.
• W4384200549 cites W1511657256 @default.
• W4384200549 cites W1778825880 @default.
• W4384200549 cites W1969463403 @default.
• W4384200549 cites W1972535886 @default.
• W4384200549 cites W1975152371 @default.
• W4384200549 cites W1986727315 @default.
• W4384200549 cites W1991500417 @default.
• W4384200549 cites W2000292756 @default.
• W4384200549 cites W2025463958 @default.
• W4384200549 cites W2033008366 @default.
• W4384200549 cites W2046044305 @default.
• W4384200549 cites W2046527998 @default.
• W4384200549 cites W2052748040 @default.
• W4384200549 cites W2053069685 @default.
• W4384200549 cites W2055571476 @default.
• W4384200549 cites W2056953534 @default.
• W4384200549 cites W2064604759 @default.
• W4384200549 cites W2079239864 @default.
• W4384200549 cites W2080569338 @default.
• W4384200549 cites W2089771664 @default.
• W4384200549 cites W2092580992 @default.
• W4384200549 cites W2093274439 @default.
• W4384200549 cites W2093330684 @default.
• W4384200549 cites W2096788531 @default.
• W4384200549 cites W2098021818 @default.
• W4384200549 cites W2101907793 @default.
• W4384200549 cites W2124046648 @default.
• W4384200549 cites W2125393836 @default.
• W4384200549 cites W2135268358 @default.
• W4384200549 cites W2158825633 @default.
• W4384200549 cites W2159826091 @default.
• W4384200549 cites W2161970884 @default.
• W4384200549 cites W2164990391 @default.
• W4384200549 cites W2165905943 @default.
• W4384200549 cites W2171658284 @default.
• W4384200549 cites W2171760785 @default.
• W4384200549 cites W2255691977 @default.
• W4384200549 cites W2289813931 @default.
• W4384200549 cites W2331854215 @default.
• W4384200549 cites W2406658896 @default.
• W4384200549 cites W2416386386 @default.
• W4384200549 cites W2507174567 @default.
• W4384200549 cites W2565726191 @default.
• W4384200549 cites W2575911653 @default.
• W4384200549 cites W2581605534 @default.
• W4384200549 cites W2620241325 @default.
• W4384200549 cites W2731418165 @default.
• W4384200549 cites W2735817878 @default.
• W4384200549 cites W2749069611 @default.
• W4384200549 cites W2806678077 @default.
• W4384200549 cites W2809541034 @default.
• W4384200549 cites W2896915094 @default.
• W4384200549 cites W2906019820 @default.
• W4384200549 cites W2944920235 @default.
• W4384200549 cites W2981949133 @default.
• W4384200549 cites W3006682083 @default.
• W4384200549 cites W3023757607 @default.
• W4384200549 cites W3080714364 @default.
• W4384200549 cites W3096816149 @default.
• W4384200549 cites W3115144960 @default.
• W4384200549 cites W3116062321 @default.
• W4384200549 cites W3162308386 @default.
• W4384200549 cites W3164176688 @default.
• W4384200549 cites W3174399704 @default.
• W4384200549 doi "https://doi.org/10.3389/fvets.2023.1127099" @default.
• W4384200549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37520007" @default.
• W4384200549 hasPublicationYear "2023" @default.
• W4384200549 type Work @default.
• W4384200549 citedByCount "0" @default.
• W4384200549 crossrefType "journal-article" @default.
• W4384200549 hasAuthorship W4384200549A5000553473 @default.
• W4384200549 hasAuthorship W4384200549A5003819014 @default.
• W4384200549 hasAuthorship W4384200549A5033470942 @default.
• W4384200549 hasAuthorship W4384200549A5034786904 @default.
• W4384200549 hasAuthorship W4384200549A5035783588 @default.
• W4384200549 hasAuthorship W4384200549A5041872862 @default.
• W4384200549 hasAuthorship W4384200549A5043956829 @default.
• W4384200549 hasAuthorship W4384200549A5052192959 @default.
• W4384200549 hasAuthorship W4384200549A5083699814 @default.
• W4384200549 hasBestOaLocation W43842005491 @default.
• W4384200549 hasConcept C126322002 @default.
• W4384200549 hasConcept C203014093 @default.
• W4384200549 hasConcept C2776246508 @default.
• W4384200549 hasConcept C2776914184 @default.
• W4384200549 hasConcept C2777628635 @default.
• W4384200549 hasConcept C2778384902 @default.

• next