Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384201440> ?p ?o ?g. }
- W4384201440 endingPage "1061" @default.
- W4384201440 startingPage "1061" @default.
- W4384201440 abstract "Apathy, a frequent neuropsychiatric symptom in aging neurocognitive disorders, has been associated with cognitive decline and functional disability. Therefore, timely provision of pharmacological interventions for apathy is greatly needed.A systematical literature review of existing studies was conducted up to 30 May 2023 in several databases (PubMed, PsychInfo, Cochrane, Google Scholar, etc.) that included randomized controlled trials (RCTs) and meta-analyses assessing pharmacological treatments for apathy in aging neurocognitive disorders. The quality of the studies was appraised.In patients with Alzheimer's Disease (AD), donepezil, galantamine, rivastigmine, methylphenidate, and gingko biloba were proven efficacious for apathy, while rivastigmine, cognitive enhancer IRL752 and piribedil were found to be beneficial in patients with Parkinson's Disease (PD) and agomelatine in patients with Frontotemporal Dementia (FD). The extensive proportion of RCTs in which apathy was used as a secondary outcome measure, along with the considerable methodological heterogeneity, did not allow the evaluation of group effects.Pharmacological interventions for apathy in aging neurocognitive disorders are complex and under-investigated. The continuation of systematic research efforts and the provision of individualized treatment for patients suffering from these disorders is vital." @default.
- W4384201440 created "2023-07-14" @default.
- W4384201440 creator A5023591795 @default.
- W4384201440 creator A5040542387 @default.
- W4384201440 creator A5042620146 @default.
- W4384201440 creator A5043950593 @default.
- W4384201440 creator A5065465237 @default.
- W4384201440 creator A5087578031 @default.
- W4384201440 date "2023-07-12" @default.
- W4384201440 modified "2023-10-18" @default.
- W4384201440 title "A Systematic Review of Pharmacological Interventions for Apathy in Aging Neurocognitive Disorders" @default.
- W4384201440 cites W1514206567 @default.
- W4384201440 cites W1583904653 @default.
- W4384201440 cites W1879838490 @default.
- W4384201440 cites W1943122846 @default.
- W4384201440 cites W1944361424 @default.
- W4384201440 cites W1975546859 @default.
- W4384201440 cites W1975975999 @default.
- W4384201440 cites W1976117775 @default.
- W4384201440 cites W1979742519 @default.
- W4384201440 cites W1982921548 @default.
- W4384201440 cites W1983669432 @default.
- W4384201440 cites W1985048555 @default.
- W4384201440 cites W1997659839 @default.
- W4384201440 cites W1997886955 @default.
- W4384201440 cites W2000123680 @default.
- W4384201440 cites W2000533277 @default.
- W4384201440 cites W2004882945 @default.
- W4384201440 cites W2005055799 @default.
- W4384201440 cites W2010096675 @default.
- W4384201440 cites W2015683060 @default.
- W4384201440 cites W2019691789 @default.
- W4384201440 cites W2022117805 @default.
- W4384201440 cites W2024120885 @default.
- W4384201440 cites W2030689331 @default.
- W4384201440 cites W2030994918 @default.
- W4384201440 cites W2031743984 @default.
- W4384201440 cites W2033307745 @default.
- W4384201440 cites W2036047573 @default.
- W4384201440 cites W2041976344 @default.
- W4384201440 cites W2044054388 @default.
- W4384201440 cites W2044482065 @default.
- W4384201440 cites W2045836468 @default.
- W4384201440 cites W2052830713 @default.
- W4384201440 cites W2055975970 @default.
- W4384201440 cites W2058112065 @default.
- W4384201440 cites W2064887457 @default.
- W4384201440 cites W2065741910 @default.
- W4384201440 cites W2068228921 @default.
- W4384201440 cites W2077099612 @default.
- W4384201440 cites W2092356280 @default.
- W4384201440 cites W2093814555 @default.
- W4384201440 cites W2097259171 @default.
- W4384201440 cites W2098008719 @default.
- W4384201440 cites W2098487858 @default.
- W4384201440 cites W2098906249 @default.
- W4384201440 cites W2098923148 @default.
- W4384201440 cites W2099532845 @default.
- W4384201440 cites W2099611723 @default.
- W4384201440 cites W2099833638 @default.
- W4384201440 cites W2102968146 @default.
- W4384201440 cites W2108335346 @default.
- W4384201440 cites W2112549296 @default.
- W4384201440 cites W2112815097 @default.
- W4384201440 cites W2112914675 @default.
- W4384201440 cites W2116018809 @default.
- W4384201440 cites W2116249921 @default.
- W4384201440 cites W2116639272 @default.
- W4384201440 cites W2116806027 @default.
- W4384201440 cites W2117134611 @default.
- W4384201440 cites W2120947429 @default.
- W4384201440 cites W2122813545 @default.
- W4384201440 cites W2123462827 @default.
- W4384201440 cites W2124065800 @default.
- W4384201440 cites W2124214624 @default.
- W4384201440 cites W2125508857 @default.
- W4384201440 cites W2128711456 @default.
- W4384201440 cites W2129036744 @default.
- W4384201440 cites W2132806643 @default.
- W4384201440 cites W2133710857 @default.
- W4384201440 cites W2136601432 @default.
- W4384201440 cites W2137014450 @default.
- W4384201440 cites W2138883123 @default.
- W4384201440 cites W2139046272 @default.
- W4384201440 cites W2142666554 @default.
- W4384201440 cites W2148791092 @default.
- W4384201440 cites W2149626554 @default.
- W4384201440 cites W2151063521 @default.
- W4384201440 cites W2151615457 @default.
- W4384201440 cites W2152370183 @default.
- W4384201440 cites W2158609513 @default.
- W4384201440 cites W2161972502 @default.
- W4384201440 cites W2163186438 @default.
- W4384201440 cites W2163226288 @default.
- W4384201440 cites W2167862712 @default.
- W4384201440 cites W2167951079 @default.
- W4384201440 cites W2169509396 @default.
- W4384201440 cites W2260948308 @default.