Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384201492> ?p ?o ?g. }
- W4384201492 endingPage "4646" @default.
- W4384201492 startingPage "4646" @default.
- W4384201492 abstract "Gastric cancer is a heterogeneous disease with diverse histological and genomic subtypes, making it difficult to demonstrate treatment efficacy in clinical trials. However, recent efforts have been made to identify molecular biomarkers with prognostic and predictive implications to better understand the broad heterogeneity of gastric cancer and develop effective targeted therapies for it. HER2 overexpression, HER2/neu amplification, MSI-H, and PD-L1+ are predictive biomarkers in gastric cancer, and a growing number of clinical trials based on novel biomarkers have demonstrated the efficacy of targeted therapies alone or in combination with conventional chemotherapy. Enrichment design clinical trials of targeted therapies against FGFR2b and claudin 18.2 have demonstrated efficacy in unresectable advanced gastric cancer. Nonetheless, it is essential to continuously validate promising molecular biomarkers and introduce them into clinical practice to optimize treatment selection and improve patient outcomes. In this review, we focused on established (PD-L1, HER2, MSI) and emerging biomarkers (FGFR2, CLDN18.2) in gastric cancer, their clinical significance, detection methods, limitations, and molecular agents that target these biomarkers." @default.
- W4384201492 created "2023-07-14" @default.
- W4384201492 creator A5006474560 @default.
- W4384201492 creator A5015125428 @default.
- W4384201492 creator A5016728036 @default.
- W4384201492 creator A5021158752 @default.
- W4384201492 creator A5030298726 @default.
- W4384201492 creator A5042912300 @default.
- W4384201492 creator A5061807887 @default.
- W4384201492 creator A5084113589 @default.
- W4384201492 creator A5090795865 @default.
- W4384201492 date "2023-07-12" @default.
- W4384201492 modified "2023-10-18" @default.
- W4384201492 title "Novel Biomarkers of Gastric Cancer: Current Research and Future Perspectives" @default.
- W4384201492 cites W1277869758 @default.
- W4384201492 cites W1802949207 @default.
- W4384201492 cites W1974893818 @default.
- W4384201492 cites W1987991390 @default.
- W4384201492 cites W1991691118 @default.
- W4384201492 cites W2004630197 @default.
- W4384201492 cites W2005069110 @default.
- W4384201492 cites W2005792607 @default.
- W4384201492 cites W2010389831 @default.
- W4384201492 cites W2012550724 @default.
- W4384201492 cites W2015918488 @default.
- W4384201492 cites W2030748852 @default.
- W4384201492 cites W2036848524 @default.
- W4384201492 cites W2037660795 @default.
- W4384201492 cites W2043711125 @default.
- W4384201492 cites W2049397238 @default.
- W4384201492 cites W2050658928 @default.
- W4384201492 cites W2066671159 @default.
- W4384201492 cites W2070165643 @default.
- W4384201492 cites W2070594517 @default.
- W4384201492 cites W2071416889 @default.
- W4384201492 cites W2091448280 @default.
- W4384201492 cites W2095605190 @default.
- W4384201492 cites W2100439220 @default.
- W4384201492 cites W2108902851 @default.
- W4384201492 cites W2114281628 @default.
- W4384201492 cites W2124295966 @default.
- W4384201492 cites W2125535566 @default.
- W4384201492 cites W2126547130 @default.
- W4384201492 cites W2138993970 @default.
- W4384201492 cites W2155464214 @default.
- W4384201492 cites W2157473448 @default.
- W4384201492 cites W2166662324 @default.
- W4384201492 cites W2169782526 @default.
- W4384201492 cites W2170505336 @default.
- W4384201492 cites W2198367850 @default.
- W4384201492 cites W2227537884 @default.
- W4384201492 cites W2264000214 @default.
- W4384201492 cites W2298468092 @default.
- W4384201492 cites W2300582328 @default.
- W4384201492 cites W2305788109 @default.
- W4384201492 cites W2324716781 @default.
- W4384201492 cites W2400239962 @default.
- W4384201492 cites W2412437118 @default.
- W4384201492 cites W2466335605 @default.
- W4384201492 cites W2507354993 @default.
- W4384201492 cites W2560367415 @default.
- W4384201492 cites W2590497374 @default.
- W4384201492 cites W2590846932 @default.
- W4384201492 cites W2592337042 @default.
- W4384201492 cites W2612431515 @default.
- W4384201492 cites W2737578400 @default.
- W4384201492 cites W2767612092 @default.
- W4384201492 cites W2790079100 @default.
- W4384201492 cites W2791483720 @default.
- W4384201492 cites W2793364080 @default.
- W4384201492 cites W2796494201 @default.
- W4384201492 cites W2801657532 @default.
- W4384201492 cites W2806614796 @default.
- W4384201492 cites W2807165179 @default.
- W4384201492 cites W2884397450 @default.
- W4384201492 cites W2886987811 @default.
- W4384201492 cites W2893194336 @default.
- W4384201492 cites W2898174432 @default.
- W4384201492 cites W2898867204 @default.
- W4384201492 cites W2904154186 @default.
- W4384201492 cites W2904154481 @default.
- W4384201492 cites W2910775131 @default.
- W4384201492 cites W2911844555 @default.
- W4384201492 cites W2916508569 @default.
- W4384201492 cites W2924122631 @default.
- W4384201492 cites W2942306949 @default.
- W4384201492 cites W2945450311 @default.
- W4384201492 cites W2955746156 @default.
- W4384201492 cites W2961375913 @default.
- W4384201492 cites W2969377494 @default.
- W4384201492 cites W2969394442 @default.
- W4384201492 cites W2972751531 @default.
- W4384201492 cites W2981366973 @default.
- W4384201492 cites W2981618459 @default.
- W4384201492 cites W2988124258 @default.
- W4384201492 cites W2998841267 @default.
- W4384201492 cites W3004602122 @default.
- W4384201492 cites W3005521521 @default.