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- W4384201699 abstract "Chronic kidney disease (CKD) affects 10% of the population. Fibrosis is the hallmark of CKD, which is marked by the deposit of extracellular matrix (ECM). This response is the final outcome of an unbalanced reaction to inflammation and wound healing and can be induced by a variety of insults, including hypoxia. Vascular damage results in an impaired tissue oxygen supply, inducing immune cell infiltration, tubule injury and the activation of ECM-secreting myofibroblasts. In turn, tubulointerstitial fibrosis development worsens oxygen diffusion. Hypoxia-inducible factor (HIF) is the primary transcriptional regulator of hypoxia-associated responses, such as oxidative stress and metabolic reprogramming, triggering a proinflammatory and profibrotic landscape. In this review, we discuss hypoxia-driven reprogramming in CKD as well as potential therapeutic approaches to target chronic hypoxia." @default.
- W4384201699 created "2023-07-14" @default.
- W4384201699 creator A5008122483 @default.
- W4384201699 creator A5081442628 @default.
- W4384201699 date "2023-07-12" @default.
- W4384201699 modified "2023-09-29" @default.
- W4384201699 title "Hypoxia-Driven Responses in Chronic Kidney Disease" @default.
- W4384201699 cites W1008398044 @default.
- W4384201699 cites W1609918614 @default.
- W4384201699 cites W1843481816 @default.
- W4384201699 cites W1922600631 @default.
- W4384201699 cites W1961909698 @default.
- W4384201699 cites W1964129553 @default.
- W4384201699 cites W1964149143 @default.
- W4384201699 cites W1965699247 @default.
- W4384201699 cites W1966968804 @default.
- W4384201699 cites W1967996568 @default.
- W4384201699 cites W1969080012 @default.
- W4384201699 cites W1969565191 @default.
- W4384201699 cites W1971411820 @default.
- W4384201699 cites W1973850434 @default.
- W4384201699 cites W1977079786 @default.
- W4384201699 cites W1978218438 @default.
- W4384201699 cites W1981253971 @default.
- W4384201699 cites W1982519941 @default.
- W4384201699 cites W1991346678 @default.
- W4384201699 cites W1993324234 @default.
- W4384201699 cites W1993529158 @default.
- W4384201699 cites W1994773464 @default.
- W4384201699 cites W1998226806 @default.
- W4384201699 cites W1998992316 @default.
- W4384201699 cites W2000606463 @default.
- W4384201699 cites W2000624133 @default.
- W4384201699 cites W2000837348 @default.
- W4384201699 cites W2001401534 @default.
- W4384201699 cites W2001544028 @default.
- W4384201699 cites W2008347760 @default.
- W4384201699 cites W2009027425 @default.
- W4384201699 cites W2009466546 @default.
- W4384201699 cites W2010449491 @default.
- W4384201699 cites W2012532020 @default.
- W4384201699 cites W2013259362 @default.
- W4384201699 cites W2015392958 @default.
- W4384201699 cites W2019119805 @default.
- W4384201699 cites W2029218698 @default.
- W4384201699 cites W2029785070 @default.
- W4384201699 cites W2033958147 @default.
- W4384201699 cites W2035655266 @default.
- W4384201699 cites W2036221290 @default.
- W4384201699 cites W2041561635 @default.
- W4384201699 cites W2042222205 @default.
- W4384201699 cites W2044982400 @default.
- W4384201699 cites W2046879590 @default.
- W4384201699 cites W2047111978 @default.
- W4384201699 cites W2049574005 @default.
- W4384201699 cites W2049774659 @default.
- W4384201699 cites W2050622384 @default.
- W4384201699 cites W2057475797 @default.
- W4384201699 cites W2059569571 @default.
- W4384201699 cites W2065164152 @default.
- W4384201699 cites W2065779229 @default.
- W4384201699 cites W2067031028 @default.
- W4384201699 cites W2067659428 @default.
- W4384201699 cites W2068842128 @default.
- W4384201699 cites W2068906486 @default.
- W4384201699 cites W2073273509 @default.
- W4384201699 cites W2074937649 @default.
- W4384201699 cites W2078987645 @default.
- W4384201699 cites W2080254537 @default.
- W4384201699 cites W2085299861 @default.
- W4384201699 cites W2085943887 @default.
- W4384201699 cites W2086248882 @default.
- W4384201699 cites W2089141914 @default.
- W4384201699 cites W2091625713 @default.
- W4384201699 cites W2095855977 @default.
- W4384201699 cites W2096468570 @default.
- W4384201699 cites W2098037959 @default.
- W4384201699 cites W2098414680 @default.
- W4384201699 cites W2101901896 @default.
- W4384201699 cites W2103154710 @default.
- W4384201699 cites W2104760558 @default.
- W4384201699 cites W2105176807 @default.
- W4384201699 cites W2107468794 @default.
- W4384201699 cites W2107655383 @default.
- W4384201699 cites W2111850449 @default.
- W4384201699 cites W2113881372 @default.
- W4384201699 cites W2114070475 @default.
- W4384201699 cites W2117261670 @default.
- W4384201699 cites W2117911689 @default.
- W4384201699 cites W2118085952 @default.
- W4384201699 cites W2120129511 @default.
- W4384201699 cites W2122983268 @default.
- W4384201699 cites W2124111730 @default.
- W4384201699 cites W2127892419 @default.
- W4384201699 cites W2128718756 @default.
- W4384201699 cites W2128821627 @default.
- W4384201699 cites W2131897198 @default.
- W4384201699 cites W2133231668 @default.