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- W4384201833 startingPage "995" @default.
- W4384201833 abstract "Ischemic heart disease (IHD) is a major cause of mortality and morbidity worldwide, with novel therapeutic strategies urgently needed. Endothelial dysfunction is a hallmark of IHD, contributing to its development and progression. Hypoxia-inducible factors (HIFs) are transcription factors activated in response to low oxygen levels, playing crucial roles in various pathophysiological processes related to cardiovascular diseases. Among the HIF isoforms, HIF2α is predominantly expressed in cardiac vascular endothelial cells and has a key role in cardiovascular diseases. HIFβ, also known as ARNT, is the obligate binding partner of HIFα subunits and is necessary for HIFα's transcriptional activity. ARNT itself plays an essential role in the development of the cardiovascular system, regulating angiogenesis, limiting inflammatory cytokine production, and protecting against cardiomyopathy. This review provides an overview of the current understanding of HIF2α and ARNT signaling in endothelial cell function and dysfunction and their involvement in IHD pathogenesis. We highlight their roles in inflammation and maintaining the integrity of the endothelial barrier, as well as their potential as therapeutic targets for IHD." @default.
- W4384201833 created "2023-07-14" @default.
- W4384201833 creator A5036847022 @default.
- W4384201833 creator A5054395607 @default.
- W4384201833 creator A5056013791 @default.
- W4384201833 creator A5075781971 @default.
- W4384201833 date "2023-07-13" @default.
- W4384201833 modified "2023-09-25" @default.
- W4384201833 title "Targeting Endothelial HIF2α/ARNT Expression for Ischemic Heart Disease Therapy" @default.
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