Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384201893> ?p ?o ?g. }
- W4384201893 endingPage "6665" @default.
- W4384201893 startingPage "6648" @default.
- W4384201893 abstract "Statins are widely used due to their ability to lower plasma cholesterol and offer protection from the effects of atherosclerosis. However, their role in urology and specifically bladder cancer remains unclear. We aimed to systematically address this issue in the literature and determine any possible effects of statin therapy on bladder cancer.We searched MEDLINE (PubMed) and Cochrane Library databases for records up to 26 March 2023, for studies evaluating the effects of statins on urinary bladder cancer (UBC). We included all randomized controlled trials (RCTs), cohorts, and case-control studies that were conducted on the adult population. PROSPERO registration number: CRD42023407795.Database searches returned 2251 reports, and after thorough investigation and assessment for eligibility, 32 reports were included in the analysis. Of them, 4 were RCTs, 6 were case-control studies, and 22 were cohort studies. Our qualitative analysis demonstrated no association between statin administration and UBC local control, recurrence, survival, or mortality, or between statin administration and bacille Calmette-Guérin (BCG) immunotherapy effectiveness. A meta-analysis of 10 trials revealed a non-significant reduction of 11% in UBC risk among users compared with non-users in RCTs (RR: 0.89, 95% CI 0.68-1.16, p = 0.37) and a non-significant increase of 32% of UBC risk among statin users compared with non-users in the analysis of the cohort studies (RR: 1.32, 95% CI 0.76-2.30, p = 0.33).Our results provide strong evidence to support the neutral effect of statins on UBC local control, recurrence, survival, and mortality, and on BCG immunotherapy. Our meta-analysis revealed a non-significant effect on UBC risk among statin users when compared with non-users, indicating no statin effect on UBC incidence and overall prognosis." @default.
- W4384201893 created "2023-07-14" @default.
- W4384201893 creator A5002384640 @default.
- W4384201893 creator A5085968028 @default.
- W4384201893 creator A5088348112 @default.
- W4384201893 creator A5092463713 @default.
- W4384201893 date "2023-07-12" @default.
- W4384201893 modified "2023-09-26" @default.
- W4384201893 title "The Effect of Statins on the Incidence and Prognosis of Bladder Cancer: A Systematic Review and Meta-Analysis" @default.
- W4384201893 cites W1529024368 @default.
- W4384201893 cites W1545863921 @default.
- W4384201893 cites W1938769679 @default.
- W4384201893 cites W1966023484 @default.
- W4384201893 cites W1968444058 @default.
- W4384201893 cites W1970005961 @default.
- W4384201893 cites W1971403921 @default.
- W4384201893 cites W1973491874 @default.
- W4384201893 cites W2013817291 @default.
- W4384201893 cites W2019411105 @default.
- W4384201893 cites W2021103317 @default.
- W4384201893 cites W2037714984 @default.
- W4384201893 cites W2042944093 @default.
- W4384201893 cites W2043263931 @default.
- W4384201893 cites W2046213723 @default.
- W4384201893 cites W2057226699 @default.
- W4384201893 cites W2067565849 @default.
- W4384201893 cites W2073425770 @default.
- W4384201893 cites W2076864596 @default.
- W4384201893 cites W2093843102 @default.
- W4384201893 cites W2096289521 @default.
- W4384201893 cites W2120509289 @default.
- W4384201893 cites W2129732555 @default.
- W4384201893 cites W2139476968 @default.
- W4384201893 cites W2140135184 @default.
- W4384201893 cites W2144051352 @default.
- W4384201893 cites W2156988984 @default.
- W4384201893 cites W2165602583 @default.
- W4384201893 cites W2167045683 @default.
- W4384201893 cites W2168650051 @default.
- W4384201893 cites W2177460719 @default.
- W4384201893 cites W2216726364 @default.
- W4384201893 cites W2274051839 @default.
- W4384201893 cites W2346664883 @default.
- W4384201893 cites W2398865945 @default.
- W4384201893 cites W2409645336 @default.
- W4384201893 cites W2534069516 @default.
- W4384201893 cites W2586086234 @default.
- W4384201893 cites W2749616207 @default.
- W4384201893 cites W2777287390 @default.
- W4384201893 cites W2891682516 @default.
- W4384201893 cites W2898703046 @default.
- W4384201893 cites W2905331745 @default.
- W4384201893 cites W2912228486 @default.
- W4384201893 cites W2970684805 @default.
- W4384201893 cites W3015939340 @default.
- W4384201893 cites W3019350884 @default.
- W4384201893 cites W3084764100 @default.
- W4384201893 cites W3092976918 @default.
- W4384201893 cites W3102329725 @default.
- W4384201893 cites W3102891280 @default.
- W4384201893 cites W3117118794 @default.
- W4384201893 cites W3118615836 @default.
- W4384201893 cites W3120229032 @default.
- W4384201893 cites W3161342535 @default.
- W4384201893 cites W3173331495 @default.
- W4384201893 cites W3198719997 @default.
- W4384201893 cites W3200741272 @default.
- W4384201893 cites W3207715707 @default.
- W4384201893 cites W3210813105 @default.
- W4384201893 cites W4205279929 @default.
- W4384201893 cites W4220830564 @default.
- W4384201893 cites W4225879583 @default.
- W4384201893 cites W4230928226 @default.
- W4384201893 cites W4287219051 @default.
- W4384201893 doi "https://doi.org/10.3390/curroncol30070488" @default.
- W4384201893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37504348" @default.
- W4384201893 hasPublicationYear "2023" @default.
- W4384201893 type Work @default.
- W4384201893 citedByCount "0" @default.
- W4384201893 crossrefType "journal-article" @default.
- W4384201893 hasAuthorship W4384201893A5002384640 @default.
- W4384201893 hasAuthorship W4384201893A5085968028 @default.
- W4384201893 hasAuthorship W4384201893A5088348112 @default.
- W4384201893 hasAuthorship W4384201893A5092463713 @default.
- W4384201893 hasBestOaLocation W43842018931 @default.
- W4384201893 hasConcept C120665830 @default.
- W4384201893 hasConcept C121332964 @default.
- W4384201893 hasConcept C121608353 @default.
- W4384201893 hasConcept C126322002 @default.
- W4384201893 hasConcept C143998085 @default.
- W4384201893 hasConcept C168563851 @default.
- W4384201893 hasConcept C17744445 @default.
- W4384201893 hasConcept C199539241 @default.
- W4384201893 hasConcept C201903717 @default.
- W4384201893 hasConcept C2776478404 @default.
- W4384201893 hasConcept C2776839432 @default.
- W4384201893 hasConcept C2779473830 @default.
- W4384201893 hasConcept C2780352672 @default.