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- W4384202273 endingPage "3591" @default.
- W4384202273 startingPage "3591" @default.
- W4384202273 abstract "In appendiceal cancers, the most frequently mutated genes are (i) KRAS, which, when reactivated, restores signal transduction via the RAS-RAF-MEK-ERK signaling pathway and stimulates cell proliferation in the early stages of tumor transformation, and then angiogenesis; (ii) TP53, whose inactivation leads to the inhibition of programmed cell death; (iii) GNAS, which, when reactivated, links the cAMP pathway to the RAS-RAF-MEK-ERK signaling pathway, stimulating cell proliferation and angiogenesis; (iv) SMAD4, exhibiting typical tumor-suppressive activity, blocking the transmission of oncogenic TGFB signals via the SMAD2/SMAD3 heterodimer; and (v) BRAF, which is part of the RAS-RAF-MEK-ERK signaling pathway. Diverse mutations are reported in other genes, which are part of secondary or less critical signaling pathways for tumor progression, but which amplify the phenotypic diversity of appendiceal cancers. In this review, we will present the main genetic mutations involved in appendix tumors and their roles in cell proliferation and survival, and in tumor invasiveness, angiogenesis, and acquired resistance to anti-growth signals." @default.
- W4384202273 created "2023-07-14" @default.
- W4384202273 creator A5009780634 @default.
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- W4384202273 creator A5084077366 @default.
- W4384202273 creator A5092463809 @default.
- W4384202273 date "2023-07-12" @default.
- W4384202273 modified "2023-09-26" @default.
- W4384202273 title "Landscape of Genetic Mutations in Appendiceal Cancers" @default.
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