Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384202357> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W4384202357 abstract "Background: People with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) experience core symptoms of post-exertional malaise, unrefreshing sleep, and cognitive impairment. Despite numbering 0.2-0.4% of the population, no laboratory test is available for their diagnosis, no effective therapy exists for their treatment, and no scientific breakthrough regarding pathogenesis has been made. It remains unknown, despite decades of small-scale studies, whether individuals experience different types of ME/CFS separated by onset-type, sex or age. Methods: DecodeME is a large population-based study of ME/CFS that recruited 17,074 participants in the first 3 months following full launch. Detailed questionnaire responses from UK-based participants who all reported being diagnosed with ME/CFS by a health professional provided an unparalleled opportunity to investigate, using logistic regression, whether ME/CFS severity or onset type is significantly associated with sex, age, illness duration, comorbid conditions or symptoms. Results: The well-established sex-bias among ME/CFS patients is evident in the initial DecodeME cohort: 83.5% of participants were females. What was not known previously was that females tend to have more comorbidities than males. Moreover, being female, being older and being over 10 years from ME/CFS onset are significantly associated with greater severity. Five different ME/CFS onset types were examined in the self-reported data: those with ME/CFS onset (i) after glandular fever (infectious mononucleosis); (ii) after COVID-19 infection; (iii) after other infections; (iv) without an infection at onset; and, (v) where the occurrence of an infection at or preceding onset is not known. Among other findings, ME/CFS onset with unknown infection status was significantly associated with active fibromyalgia. Conclusions: DecodeME participants differ in symptoms, comorbid conditions and/or illness severity when stratified by their sex-at-birth and/or infection around the time of ME/CFS onset." @default.
- W4384202357 created "2023-07-14" @default.
- W4384202357 creator A5007311654 @default.
- W4384202357 date "2023-07-13" @default.
- W4384202357 modified "2023-09-24" @default.
- W4384202357 title "Peer Review Report For: Typing myalgic encephalomyelitis by infection at onset: A DecodeME study [version 2; peer review: 1 approved, 1 approved with reservations]" @default.
- W4384202357 doi "https://doi.org/10.3310/nihropenres.14591.r29746" @default.
- W4384202357 hasPublicationYear "2023" @default.
- W4384202357 type Work @default.
- W4384202357 citedByCount "0" @default.
- W4384202357 crossrefType "peer-review" @default.
- W4384202357 hasAuthorship W4384202357A5007311654 @default.
- W4384202357 hasBestOaLocation W43842023571 @default.
- W4384202357 hasConcept C118552586 @default.
- W4384202357 hasConcept C126322002 @default.
- W4384202357 hasConcept C151956035 @default.
- W4384202357 hasConcept C187212893 @default.
- W4384202357 hasConcept C2778616394 @default.
- W4384202357 hasConcept C2779277585 @default.
- W4384202357 hasConcept C2779566273 @default.
- W4384202357 hasConcept C2908647359 @default.
- W4384202357 hasConcept C71924100 @default.
- W4384202357 hasConcept C72563966 @default.
- W4384202357 hasConcept C99454951 @default.
- W4384202357 hasConceptScore W4384202357C118552586 @default.
- W4384202357 hasConceptScore W4384202357C126322002 @default.
- W4384202357 hasConceptScore W4384202357C151956035 @default.
- W4384202357 hasConceptScore W4384202357C187212893 @default.
- W4384202357 hasConceptScore W4384202357C2778616394 @default.
- W4384202357 hasConceptScore W4384202357C2779277585 @default.
- W4384202357 hasConceptScore W4384202357C2779566273 @default.
- W4384202357 hasConceptScore W4384202357C2908647359 @default.
- W4384202357 hasConceptScore W4384202357C71924100 @default.
- W4384202357 hasConceptScore W4384202357C72563966 @default.
- W4384202357 hasConceptScore W4384202357C99454951 @default.
- W4384202357 hasLocation W43842023571 @default.
- W4384202357 hasOpenAccess W4384202357 @default.
- W4384202357 hasPrimaryLocation W43842023571 @default.
- W4384202357 hasRelatedWork W1851563356 @default.
- W4384202357 hasRelatedWork W2057746847 @default.
- W4384202357 hasRelatedWork W2100287571 @default.
- W4384202357 hasRelatedWork W2142204713 @default.
- W4384202357 hasRelatedWork W2984594535 @default.
- W4384202357 hasRelatedWork W3122609042 @default.
- W4384202357 hasRelatedWork W3154413300 @default.
- W4384202357 hasRelatedWork W3202571900 @default.
- W4384202357 hasRelatedWork W4297184102 @default.
- W4384202357 hasRelatedWork W9959240 @default.
- W4384202357 isParatext "false" @default.
- W4384202357 isRetracted "false" @default.
- W4384202357 workType "peer-review" @default.