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- W4384202878 endingPage "11377" @default.
- W4384202878 startingPage "11377" @default.
- W4384202878 abstract "The changes in epigenetic modifications during early embryonic development significantly impact mammalian embryonic genome activation (EGA) and are species-conserved to some degree. Here, we reanalyzed the published RNA-Seq of human, mouse, and goat early embryos and found that Zfp296 (zinc finger protein 296) expression was higher at the EGA stage than at the oocyte stage in all three species (adjusted p-value < 0.05 |log2(foldchange)| ≥ 1). Subsequently, we found that Zfp296 was conserved across human, mouse, goat, sheep, pig, and bovine embryos. In addition, we identified that ZFP296 interacts with the epigenetic regulators KDM5B, SMARCA4, DNMT1, DNMT3B, HP1β, and UHRF1. The Cys2-His2(C2H2) zinc finger domain TYPE2 TYPE3 domains of ZFP296 co-regulated the modification level of the trimethylation of lysine 9 on the histone H3 protein subunit (H3K9me3). According to ChIP-seq analysis, ZFP296 was also enriched in Trim28, Suv39h1, Setdb1, Kdm4a, and Ehmt2 in the mESC genome. Then, knockdown of the expression of Zfp296 at the late zygote of the mouse led to the early developmental arrest of the mouse embryos and failure resulting from a decrease in H3K9me3. Together, our results reveal that Zfp296 is an H3K9me3 modulator which is essential to the embryonic genome activation of mouse embryos." @default.
- W4384202878 created "2023-07-14" @default.
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- W4384202878 date "2023-07-12" @default.
- W4384202878 modified "2023-10-15" @default.
- W4384202878 title "The Novel Role of Zfp296 in Mammalian Embryonic Genome Activation as an H3K9me3 Modulator" @default.
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- W4384202878 doi "https://doi.org/10.3390/ijms241411377" @default.
- W4384202878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37511136" @default.
- W4384202878 hasPublicationYear "2023" @default.
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