Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384203009> ?p ?o ?g. }
- W4384203009 abstract "HbE/β-thalassemia is the most common severe form of thalassemia which is very prominent in South East Asian countries. It is responsible for nearly one-half of all the severe types of β-thalassemia all over the world. It is also known to represent a wide range of phenotypic diversity which varies from asymptomatic to transfusion-dependent severe phenotype. The most important predictive factor is mutations within the beta-globin gene (HBB). Apart from the primary genetic modifiers, there are certain other determinants regulating the phenotypic heterogeneity including, co-inheritance of alpha thalassemia mutations and other secondary modifiers including Xmn1 polymorphism, HBS1L-MYB, GATA-1, BCL11A polymorphism, and presence of HPFH mutations. Although the degree of severity is also determined by other tertiary genetic modifiers like increase in serum erythropoietin due to anemia, previous infection with malaria, environmental factors, splenectomy, etc. This review aimed to reveal the potential genetic predictors of HbE/β-thalassemia patients and the probable management strategy. This also enhances the generation of “personalized medicine” for better patient care. The instability of clinical phenotype and remarkable variation indicate careful monitoring of treatment for each patient and the therapeutic approaches should be monitored over time." @default.
- W4384203009 created "2023-07-14" @default.
- W4384203009 creator A5002272433 @default.
- W4384203009 creator A5005087999 @default.
- W4384203009 creator A5007281896 @default.
- W4384203009 creator A5053252121 @default.
- W4384203009 date "2023-07-04" @default.
- W4384203009 modified "2023-10-04" @default.
- W4384203009 title "The Key Genetic Determinants Behind the Phenotypic Heterogeneity of HbE/β-thalassemia Patients and the Probable Management Strategy" @default.
- W4384203009 cites W1534008913 @default.
- W4384203009 cites W1598569053 @default.
- W4384203009 cites W1926758277 @default.
- W4384203009 cites W1975663296 @default.
- W4384203009 cites W1980295363 @default.
- W4384203009 cites W1981357811 @default.
- W4384203009 cites W1981826617 @default.
- W4384203009 cites W1988241536 @default.
- W4384203009 cites W1989323378 @default.
- W4384203009 cites W1994812847 @default.
- W4384203009 cites W2001570896 @default.
- W4384203009 cites W2004053059 @default.
- W4384203009 cites W2005384029 @default.
- W4384203009 cites W2008973770 @default.
- W4384203009 cites W2009824045 @default.
- W4384203009 cites W2012020901 @default.
- W4384203009 cites W2017717368 @default.
- W4384203009 cites W2019580959 @default.
- W4384203009 cites W2034719394 @default.
- W4384203009 cites W2034919160 @default.
- W4384203009 cites W2036308544 @default.
- W4384203009 cites W2045800171 @default.
- W4384203009 cites W2062266319 @default.
- W4384203009 cites W2067697375 @default.
- W4384203009 cites W2070691466 @default.
- W4384203009 cites W2070893438 @default.
- W4384203009 cites W2072881292 @default.
- W4384203009 cites W2087657427 @default.
- W4384203009 cites W2089876393 @default.
- W4384203009 cites W2091710493 @default.
- W4384203009 cites W2113488057 @default.
- W4384203009 cites W2116911290 @default.
- W4384203009 cites W2118156785 @default.
- W4384203009 cites W2124026013 @default.
- W4384203009 cites W2136920661 @default.
- W4384203009 cites W2138260210 @default.
- W4384203009 cites W2146183954 @default.
- W4384203009 cites W2149623095 @default.
- W4384203009 cites W2165261085 @default.
- W4384203009 cites W2167575052 @default.
- W4384203009 cites W2322536880 @default.
- W4384203009 cites W2332195908 @default.
- W4384203009 cites W2400335073 @default.
- W4384203009 cites W2400990757 @default.
- W4384203009 cites W2436271100 @default.
- W4384203009 cites W2515759588 @default.
- W4384203009 cites W2589277855 @default.
- W4384203009 cites W2604943138 @default.
- W4384203009 cites W2606049066 @default.
- W4384203009 cites W2623156048 @default.
- W4384203009 cites W2654493239 @default.
- W4384203009 cites W2765549450 @default.
- W4384203009 cites W2766749761 @default.
- W4384203009 cites W2795657820 @default.
- W4384203009 cites W2801411354 @default.
- W4384203009 cites W2804566227 @default.
- W4384203009 cites W2805210233 @default.
- W4384203009 cites W2890816711 @default.
- W4384203009 cites W2903234309 @default.
- W4384203009 cites W2915373590 @default.
- W4384203009 cites W2967228441 @default.
- W4384203009 cites W2992463303 @default.
- W4384203009 cites W2997092761 @default.
- W4384203009 cites W2998881619 @default.
- W4384203009 cites W3041390069 @default.
- W4384203009 cites W3082822303 @default.
- W4384203009 cites W3128181869 @default.
- W4384203009 cites W3128738408 @default.
- W4384203009 cites W3157784505 @default.
- W4384203009 cites W3194152645 @default.
- W4384203009 cites W3205464706 @default.
- W4384203009 cites W3208478075 @default.
- W4384203009 cites W4206696157 @default.
- W4384203009 cites W4207062096 @default.
- W4384203009 cites W4211119300 @default.
- W4384203009 cites W4211225058 @default.
- W4384203009 cites W4229006585 @default.
- W4384203009 cites W4251694595 @default.
- W4384203009 cites W4288072645 @default.
- W4384203009 cites W4302354217 @default.
- W4384203009 doi "https://doi.org/10.5772/intechopen.109999" @default.
- W4384203009 hasPublicationYear "2023" @default.
- W4384203009 type Work @default.
- W4384203009 citedByCount "0" @default.
- W4384203009 crossrefType "book-chapter" @default.
- W4384203009 hasAuthorship W4384203009A5002272433 @default.
- W4384203009 hasAuthorship W4384203009A5005087999 @default.
- W4384203009 hasAuthorship W4384203009A5007281896 @default.
- W4384203009 hasAuthorship W4384203009A5053252121 @default.
- W4384203009 hasBestOaLocation W43842030091 @default.
- W4384203009 hasConcept C104317684 @default.