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- W4384205255 abstract "Synthetic glucocorticoids, such as dexamethasone, have been used as a treatment for many immune conditions, such as asthma and, more recently, severe COVID-19. Single-cell data can capture more fine-grained details on transcriptional variability and dynamics to gain a better understanding of the molecular underpinnings of inter-individual variation in drug response. Here, we used single-cell RNA-seq to study the dynamics of the transcriptional response to glucocorticoids in activated peripheral blood mononuclear cells from 96 African American children. We used novel statistical approaches to calculate a mean-independent measure of gene expression variability and a measure of transcriptional response pseudotime. Using these approaches, we showed that glucocorticoids reverse the effects of immune stimulation on both gene expression mean and variability. Our novel measure of gene expression response dynamics, based on the diagonal linear discriminant analysis, separated individual cells by response status on the basis of their transcriptional profiles and allowed us to identify different dynamic patterns of gene expression along the response pseudotime. We identified genetic variants regulating gene expression mean and variability, including treatment-specific effects, and showed widespread genetic regulation of the transcriptional dynamics of the gene expression response." @default.
- W4384205255 created "2023-07-14" @default.
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- W4384205255 date "2023-06-01" @default.
- W4384205255 modified "2023-10-14" @default.
- W4384205255 title "Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single-cell resolution" @default.
- W4384205255 cites W1594591001 @default.
- W4384205255 cites W1943681383 @default.
- W4384205255 cites W1975000966 @default.
- W4384205255 cites W1979382630 @default.
- W4384205255 cites W1980725116 @default.
- W4384205255 cites W1985629708 @default.
- W4384205255 cites W1989810120 @default.
- W4384205255 cites W1990209583 @default.
- W4384205255 cites W1990219126 @default.
- W4384205255 cites W1999881162 @default.
- W4384205255 cites W2000177767 @default.
- W4384205255 cites W2009178411 @default.
- W4384205255 cites W2012697072 @default.
- W4384205255 cites W2016833582 @default.
- W4384205255 cites W2024052061 @default.
- W4384205255 cites W2031721046 @default.
- W4384205255 cites W2033343333 @default.
- W4384205255 cites W2035618305 @default.
- W4384205255 cites W2041401488 @default.
- W4384205255 cites W2056130624 @default.
- W4384205255 cites W2057692691 @default.
- W4384205255 cites W2058454627 @default.
- W4384205255 cites W2058566265 @default.
- W4384205255 cites W2084450103 @default.
- W4384205255 cites W2085871516 @default.
- W4384205255 cites W2085912059 @default.
- W4384205255 cites W2091129202 @default.
- W4384205255 cites W2091934109 @default.
- W4384205255 cites W2114899356 @default.
- W4384205255 cites W2124157828 @default.
- W4384205255 cites W2126493764 @default.
- W4384205255 cites W2128123414 @default.
- W4384205255 cites W2130809733 @default.
- W4384205255 cites W2139564620 @default.
- W4384205255 cites W2145644993 @default.
- W4384205255 cites W2146512944 @default.
- W4384205255 cites W2152095920 @default.
- W4384205255 cites W2152131300 @default.
- W4384205255 cites W2165277651 @default.
- W4384205255 cites W2168221215 @default.
- W4384205255 cites W2179438025 @default.
- W4384205255 cites W2186991921 @default.
- W4384205255 cites W2241686927 @default.
- W4384205255 cites W2269979451 @default.
- W4384205255 cites W2273101790 @default.
- W4384205255 cites W2278600110 @default.
- W4384205255 cites W2334748582 @default.
- W4384205255 cites W2418688677 @default.
- W4384205255 cites W2532435486 @default.
- W4384205255 cites W2532473654 @default.
- W4384205255 cites W2538361155 @default.
- W4384205255 cites W2547161721 @default.
- W4384205255 cites W2570629027 @default.
- W4384205255 cites W2602673171 @default.
- W4384205255 cites W2741536364 @default.
- W4384205255 cites W2744346267 @default.
- W4384205255 cites W2747877289 @default.
- W4384205255 cites W2752984482 @default.
- W4384205255 cites W2774307122 @default.
- W4384205255 cites W2775945592 @default.
- W4384205255 cites W2780232486 @default.
- W4384205255 cites W2785443776 @default.
- W4384205255 cites W2787817073 @default.
- W4384205255 cites W2794458614 @default.
- W4384205255 cites W2800392236 @default.
- W4384205255 cites W2809279441 @default.
- W4384205255 cites W2811012706 @default.
- W4384205255 cites W2887944880 @default.
- W4384205255 cites W2889435420 @default.
- W4384205255 cites W2890998227 @default.
- W4384205255 cites W2897748644 @default.
- W4384205255 cites W2904824676 @default.
- W4384205255 cites W2940265232 @default.
- W4384205255 cites W2941021319 @default.
- W4384205255 cites W2945570991 @default.
- W4384205255 cites W2948965931 @default.
- W4384205255 cites W2949177718 @default.
- W4384205255 cites W2949830473 @default.
- W4384205255 cites W2951079876 @default.
- W4384205255 cites W2951130888 @default.
- W4384205255 cites W2951370351 @default.