FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384205282> ?p ?o ?g. }

• W4384205282 abstract "Abstract: Biotin, a vitamin that is water-soluble, is part of the vitamin B complex and is required by all living things, including humans. Biotin-dependent carboxylases are a prosthetic group of enzymes, and biotin catalyzes essential processes in the production of fatty acids, the breakdown of amino acids, and gluconeogenesis in eukaryotic cells. The role of biotin as the prosthetic group of the four biotin-dependent carboxylases is well understood in higher animals. Based on the roles of these carboxylases in metabolism, it was discovered that biotin is required for cell survival, proliferation, and differentiation. Biotin appears to play a role in cell function and has a spermatogenic impact. Biotin has been found to have a direct impact on the transcription of important enzymes in glucose metabolism. Glucokinase and phosphoenolpyruvate carboxykinase are glycolytic enzymes that biotin controls (PEPCK). Biotin appears to be involved in gene control, which may explain some of its functions regarding fetal development and cellular biology. According to investigations using microarrays as well as other types of gene expression, biotin appears to affect the transcription of genes encoding cytokines and their receptors, glucose metabolism genes, and genes involved in cellular biotin homeostasis. A biotin shortage has a considerable effect on gene expression in numerous tissues and cells, according to a microarray study. Biotin supplementation affects the expression of several genes depending on the tissue, demonstrating that gene expression differences reflect tissue function. Biotin affects energy, lipid, and glucose metabolism, according to metabolite research, which has improved our understanding of the biotin metabolic pathway. Using microarray and transcriptome analysis, this research investigates the effect of biotin on gene expression." @default.
• W4384205282 created "2023-07-14" @default.
• W4384205282 creator A5002488768 @default.
• W4384205282 creator A5023345441 @default.
• W4384205282 creator A5028797814 @default.
• W4384205282 creator A5034157036 @default.
• W4384205282 creator A5040982707 @default.
• W4384205282 creator A5048085868 @default.
• W4384205282 creator A5085435957 @default.
• W4384205282 date "2023-07-12" @default.
• W4384205282 modified "2023-09-24" @default.
• W4384205282 title "Regulatory Role, Mechanism, and Metabolic Profile of BIOTIN in Gene Expression" @default.
• W4384205282 doi "https://doi.org/10.2174/1875692120666230712160812" @default.
• W4384205282 hasPublicationYear "2023" @default.
• W4384205282 type Work @default.
• W4384205282 citedByCount "0" @default.
• W4384205282 crossrefType "journal-article" @default.
• W4384205282 hasAuthorship W4384205282A5002488768 @default.
• W4384205282 hasAuthorship W4384205282A5023345441 @default.
• W4384205282 hasAuthorship W4384205282A5028797814 @default.
• W4384205282 hasAuthorship W4384205282A5034157036 @default.
• W4384205282 hasAuthorship W4384205282A5040982707 @default.
• W4384205282 hasAuthorship W4384205282A5048085868 @default.
• W4384205282 hasAuthorship W4384205282A5085435957 @default.
• W4384205282 hasConcept C104317684 @default.
• W4384205282 hasConcept C140137476 @default.
• W4384205282 hasConcept C143937172 @default.
• W4384205282 hasConcept C150194340 @default.
• W4384205282 hasConcept C181199279 @default.
• W4384205282 hasConcept C2776294945 @default.
• W4384205282 hasConcept C2778204606 @default.
• W4384205282 hasConcept C55493867 @default.
• W4384205282 hasConcept C86803240 @default.
• W4384205282 hasConceptScore W4384205282C104317684 @default.
• W4384205282 hasConceptScore W4384205282C140137476 @default.
• W4384205282 hasConceptScore W4384205282C143937172 @default.
• W4384205282 hasConceptScore W4384205282C150194340 @default.
• W4384205282 hasConceptScore W4384205282C181199279 @default.
• W4384205282 hasConceptScore W4384205282C2776294945 @default.
• W4384205282 hasConceptScore W4384205282C2778204606 @default.
• W4384205282 hasConceptScore W4384205282C55493867 @default.
• W4384205282 hasConceptScore W4384205282C86803240 @default.
• W4384205282 hasLocation W43842052821 @default.
• W4384205282 hasOpenAccess W4384205282 @default.
• W4384205282 hasPrimaryLocation W43842052821 @default.
• W4384205282 hasRelatedWork W1522046851 @default.
• W4384205282 hasRelatedWork W1562086046 @default.
• W4384205282 hasRelatedWork W1976951212 @default.
• W4384205282 hasRelatedWork W1981240755 @default.
• W4384205282 hasRelatedWork W2061541440 @default.
• W4384205282 hasRelatedWork W2137282600 @default.
• W4384205282 hasRelatedWork W2147753388 @default.
• W4384205282 hasRelatedWork W2169471064 @default.
• W4384205282 hasRelatedWork W339813795 @default.
• W4384205282 hasRelatedWork W4384205282 @default.
• W4384205282 hasVolume "20" @default.
• W4384205282 isParatext "false" @default.
• W4384205282 isRetracted "false" @default.
• W4384205282 workType "article" @default.