Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384205587> ?p ?o ?g. }
- W4384205587 abstract "Estrogen plays a protective role in colorectal cancer (CRC) and primarily functions through estrogen receptor β (ERβ). However, clinical strategies for CRC therapy associated with ERβ are still under investigation. Our discoveries identified WFDC3 as a tumor suppressor that facilitates estrogen-induced inhibition of metastasis through the ERβ/TGFBR1 signaling axis. WFDC3 interacts with ERβ and increases its protein stability by inhibiting its proteasome-dependent degradation. WFDC3 represses TGFBR1 expression through ERβ-mediated transcription. Blocking TGFβ signaling with galunisertib, a drug used in clinical trials that targets TGFBR1, impaired the migration of CRC cells induced by WFDC3 depletion. Moreover, there was clinical significance to WFDC3 in CRC, as CRC patients with high WFDC3 expression in tumor cells had favorable prognoses. Therefore, this work suggests that WFDC3 could be an indicator for therapies targeting the estrogen/ERβ pathway in CRC patients." @default.
- W4384205587 created "2023-07-14" @default.
- W4384205587 creator A5000720486 @default.
- W4384205587 creator A5003593721 @default.
- W4384205587 creator A5024955814 @default.
- W4384205587 creator A5030840389 @default.
- W4384205587 creator A5036339265 @default.
- W4384205587 creator A5036624151 @default.
- W4384205587 creator A5040497420 @default.
- W4384205587 creator A5057328522 @default.
- W4384205587 creator A5058802996 @default.
- W4384205587 creator A5059807822 @default.
- W4384205587 creator A5061396453 @default.
- W4384205587 creator A5061617558 @default.
- W4384205587 creator A5072088540 @default.
- W4384205587 date "2023-07-13" @default.
- W4384205587 modified "2023-10-17" @default.
- W4384205587 title "WFDC3 inhibits tumor metastasis by promoting the ERβ-mediated transcriptional repression of TGFBR1 in colorectal cancer" @default.
- W4384205587 cites W1966272418 @default.
- W4384205587 cites W1968444539 @default.
- W4384205587 cites W1972046516 @default.
- W4384205587 cites W1979648005 @default.
- W4384205587 cites W1979858258 @default.
- W4384205587 cites W1989954597 @default.
- W4384205587 cites W2008712121 @default.
- W4384205587 cites W2012462812 @default.
- W4384205587 cites W2046466268 @default.
- W4384205587 cites W2057907408 @default.
- W4384205587 cites W2058806672 @default.
- W4384205587 cites W2083843228 @default.
- W4384205587 cites W2095413251 @default.
- W4384205587 cites W2100437718 @default.
- W4384205587 cites W2105828062 @default.
- W4384205587 cites W2133946921 @default.
- W4384205587 cites W2139533413 @default.
- W4384205587 cites W2140860535 @default.
- W4384205587 cites W2145332276 @default.
- W4384205587 cites W2151806794 @default.
- W4384205587 cites W2152261493 @default.
- W4384205587 cites W2153716722 @default.
- W4384205587 cites W2164414963 @default.
- W4384205587 cites W2164856565 @default.
- W4384205587 cites W2170833808 @default.
- W4384205587 cites W2170929407 @default.
- W4384205587 cites W2205253366 @default.
- W4384205587 cites W2210107480 @default.
- W4384205587 cites W2289657240 @default.
- W4384205587 cites W2343520957 @default.
- W4384205587 cites W2609949780 @default.
- W4384205587 cites W2740280821 @default.
- W4384205587 cites W2751684866 @default.
- W4384205587 cites W2894052415 @default.
- W4384205587 cites W2898363549 @default.
- W4384205587 cites W2924885341 @default.
- W4384205587 cites W2939849806 @default.
- W4384205587 cites W2966873405 @default.
- W4384205587 cites W2967165574 @default.
- W4384205587 cites W2970045605 @default.
- W4384205587 cites W2971824341 @default.
- W4384205587 cites W3042891927 @default.
- W4384205587 cites W3091865300 @default.
- W4384205587 cites W3092979002 @default.
- W4384205587 cites W3114795781 @default.
- W4384205587 cites W3138896074 @default.
- W4384205587 cites W3187140882 @default.
- W4384205587 cites W3193858675 @default.
- W4384205587 cites W4206841660 @default.
- W4384205587 cites W4293860912 @default.
- W4384205587 cites W648825587 @default.
- W4384205587 doi "https://doi.org/10.1038/s41419-023-05956-0" @default.
- W4384205587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37443102" @default.
- W4384205587 hasPublicationYear "2023" @default.
- W4384205587 type Work @default.
- W4384205587 citedByCount "0" @default.
- W4384205587 crossrefType "journal-article" @default.
- W4384205587 hasAuthorship W4384205587A5000720486 @default.
- W4384205587 hasAuthorship W4384205587A5003593721 @default.
- W4384205587 hasAuthorship W4384205587A5024955814 @default.
- W4384205587 hasAuthorship W4384205587A5030840389 @default.
- W4384205587 hasAuthorship W4384205587A5036339265 @default.
- W4384205587 hasAuthorship W4384205587A5036624151 @default.
- W4384205587 hasAuthorship W4384205587A5040497420 @default.
- W4384205587 hasAuthorship W4384205587A5057328522 @default.
- W4384205587 hasAuthorship W4384205587A5058802996 @default.
- W4384205587 hasAuthorship W4384205587A5059807822 @default.
- W4384205587 hasAuthorship W4384205587A5061396453 @default.
- W4384205587 hasAuthorship W4384205587A5061617558 @default.
- W4384205587 hasAuthorship W4384205587A5072088540 @default.
- W4384205587 hasBestOaLocation W43842055871 @default.
- W4384205587 hasConcept C104317684 @default.
- W4384205587 hasConcept C121608353 @default.
- W4384205587 hasConcept C126322002 @default.
- W4384205587 hasConcept C150194340 @default.
- W4384205587 hasConcept C172313692 @default.
- W4384205587 hasConcept C179185449 @default.
- W4384205587 hasConcept C186310378 @default.
- W4384205587 hasConcept C2777164284 @default.
- W4384205587 hasConcept C2779013556 @default.
- W4384205587 hasConcept C502942594 @default.
- W4384205587 hasConcept C526805850 @default.