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• W4384206795 abstract "Abstract Juvenile hormone (JH) is an indispensable insect hormone that is critical in regulating insect development and physiology. N6-methyladenosine (m 6 A) is the most abundant modification of RNA that regulates RNA fate in eukaryotic organisms. However, the relationship between m 6 A and JH remains largely unknown. Here, we found that the application of a Juvenile hormone analog (JHA) extended the larval period of Bombyx mori and increased the weight and thickness of the cocoon. Interestingly, global transcriptional patterns revealed that m 6 A-related genes are specifically regulated by JHA in the posterior silk gland (PSG) that synthesizes the major component of cocoon silk. By transcriptome and m 6 A sequencing data conjointly, we discovered that JHA significantly regulated the m 6 A modification in the PSG of B. mori and many m 6 A-containing genes are related to nucleic acid binding, nucleus, and nucleobase-containing compound metabolism. Notably, 547 genes were significantly regulated by JHA at both the m 6 A modification and expression levels, especially 16 silk-associated genes, including sericin2 , seroin1 , BmSPI4 , BmSPI5 , and Ldb . Among them, 11 silk genes were significantly affected by METTL3 knockdown, validating that these silk genes are targets of m 6 A modification. Furthermore, we confirmed that JHA directly regulates the expression of BmSPI4 and BmSPI5 through m 6 A modification of CDS regions. These results demonstrate the essential role of m 6 A methylation regulated by JH in PSG, and elucidate a novel mechanism by which JH affects silk gland development via m 6 A methylation. This study uncovers that m 6 A modification is a critical factor mediating the effect of JH in insects." @default.
• W4384206795 created "2023-07-14" @default.
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• W4384206795 date "2023-07-13" @default.
• W4384206795 modified "2023-09-25" @default.
• W4384206795 title "Juvenile Hormone Regulates Silk Gene Expression by m6A RNA Methylation" @default.
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• W4384206795 doi "https://doi.org/10.21203/rs.3.rs-3128378/v1" @default.
• W4384206795 hasPublicationYear "2023" @default.
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