FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384206830> ?p ?o ?g. }

• W4384206830 abstract "Alleviation of motor impairment by aerobic exercise (AE) in Parkinson's disease (PD) points to a CNS response that could be targeted by therapeutic approaches, but recovery of striatal dopamine (DA) or tyrosine hydroxylase (TH) has been inconsistent in rodent studies.To increase translation of AE, 3 components were implemented into AE design to determine if recovery of established motor impairment, concomitant with >80% striatal DA and TH loss, was possible. We also evaluated if serum levels of neurofilament light (NfL) and glial fibrillary acidic protein (GFAP), blood-based biomarkers of disease severity in human PD, were affected.We used a 6-OHDA hemiparkinson rat model featuring progressive nigrostriatal neuron loss over 28 days, with impaired forelimb use 7 days post-lesion, and hypokinesia onset 21 days post-lesion. After establishing forelimb use deficits, moderate intensity AE began 1-3 days later, 3x per week, for 40 min/session. Motor assessments were conducted weekly for 3 wks, followed by determination of striatal DA, TH protein and mRNA, and NfL and GFAP serum levels.Seven days after 6-OHDA lesion, recovery of depolarization-stimulated extracellular DA and DA tissue content was <10%, representing severity of DA loss in human PD, concomitant with 50% reduction in forelimb use. Despite severe DA loss, recovery of forelimb use deficits and alleviation of hypokinesia progression began after 2 weeks of AE and was maintained. Increased NfLand GFAP levels from lesion were reduced by AE. Despite these AE-driven changes, striatal DA tissue and TH protein levels were unaffected.This proof-of-concept study shows AE, using exercise parameters within the capabilities most PD patients, promotes recovery of established motor deficits in a rodent PD model, concomitant with reduced levels of blood-based biomarkers associated with PD severity, without commensurate increase in striatal DA or TH protein." @default.
• W4384206830 created "2023-07-14" @default.
• W4384206830 creator A5000316446 @default.
• W4384206830 creator A5004278682 @default.
• W4384206830 creator A5009596285 @default.
• W4384206830 creator A5011960237 @default.
• W4384206830 creator A5019562344 @default.
• W4384206830 creator A5019929746 @default.
• W4384206830 creator A5026746873 @default.
• W4384206830 creator A5029519503 @default.
• W4384206830 creator A5030881662 @default.
• W4384206830 creator A5031707446 @default.
• W4384206830 creator A5034980606 @default.
• W4384206830 creator A5056724620 @default.
• W4384206830 creator A5071512505 @default.
• W4384206830 creator A5088022399 @default.
• W4384206830 date "2023-07-12" @default.
• W4384206830 modified "2023-09-25" @default.
• W4384206830 title "Moderate intensity aerobic exercise in 6-OHDA-lesioned rats alleviates established motor deficits and reduces neurofilament light and glial fibrillary acidic protein serum levels without increased striatal dopamine or tyrosine hydroxylase protein" @default.
• W4384206830 cites W1763255738 @default.
• W4384206830 cites W1800951710 @default.
• W4384206830 cites W1920030402 @default.
• W4384206830 cites W1967070205 @default.
• W4384206830 cites W1969542015 @default.
• W4384206830 cites W1970581195 @default.
• W4384206830 cites W1971258758 @default.
• W4384206830 cites W1978047491 @default.
• W4384206830 cites W1978793506 @default.
• W4384206830 cites W1981500052 @default.
• W4384206830 cites W1993088678 @default.
• W4384206830 cites W2006584236 @default.
• W4384206830 cites W2007358228 @default.
• W4384206830 cites W2014078610 @default.
• W4384206830 cites W2029246446 @default.
• W4384206830 cites W2042936248 @default.
• W4384206830 cites W2077789090 @default.
• W4384206830 cites W2092462980 @default.
• W4384206830 cites W2118208551 @default.
• W4384206830 cites W2127113304 @default.
• W4384206830 cites W2129917779 @default.
• W4384206830 cites W2130087282 @default.
• W4384206830 cites W2132329166 @default.
• W4384206830 cites W2134886133 @default.
• W4384206830 cites W2143472026 @default.
• W4384206830 cites W2143978324 @default.
• W4384206830 cites W2156606713 @default.
• W4384206830 cites W2176170894 @default.
• W4384206830 cites W2252122829 @default.
• W4384206830 cites W2335177398 @default.
• W4384206830 cites W2471855549 @default.
• W4384206830 cites W2574348854 @default.
• W4384206830 cites W2587649617 @default.
• W4384206830 cites W2600577557 @default.
• W4384206830 cites W2665730350 @default.
• W4384206830 cites W2742475176 @default.
• W4384206830 cites W2762186704 @default.
• W4384206830 cites W2770101482 @default.
• W4384206830 cites W2780697315 @default.
• W4384206830 cites W2783322603 @default.
• W4384206830 cites W2791657872 @default.
• W4384206830 cites W2794623970 @default.
• W4384206830 cites W2852358493 @default.
• W4384206830 cites W2884624136 @default.
• W4384206830 cites W2901529378 @default.
• W4384206830 cites W2912414522 @default.
• W4384206830 cites W2972993683 @default.
• W4384206830 cites W2978615354 @default.
• W4384206830 cites W2983897971 @default.
• W4384206830 cites W3010982853 @default.
• W4384206830 cites W3025356263 @default.
• W4384206830 cites W3086309283 @default.
• W4384206830 cites W3127951342 @default.
• W4384206830 cites W3130544983 @default.
• W4384206830 cites W3135025255 @default.
• W4384206830 cites W3154237080 @default.
• W4384206830 cites W3193698668 @default.
• W4384206830 cites W3201541305 @default.
• W4384206830 cites W3210849595 @default.
• W4384206830 cites W3212609515 @default.
• W4384206830 cites W4200063126 @default.
• W4384206830 cites W4221007492 @default.
• W4384206830 cites W4281708864 @default.
• W4384206830 cites W4283392263 @default.
• W4384206830 cites W4288077214 @default.
• W4384206830 cites W4291809437 @default.
• W4384206830 cites W4311101968 @default.
• W4384206830 cites W4319826322 @default.
• W4384206830 cites W4362506627 @default.
• W4384206830 cites W4366084343 @default.
• W4384206830 cites W4376132293 @default.
• W4384206830 cites W4376867794 @default.
• W4384206830 doi "https://doi.org/10.1101/2023.07.11.548638" @default.
• W4384206830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37502851" @default.
• W4384206830 hasPublicationYear "2023" @default.
• W4384206830 type Work @default.
• W4384206830 citedByCount "0" @default.
• W4384206830 crossrefType "posted-content" @default.
• W4384206830 hasAuthorship W4384206830A5000316446 @default.
• W4384206830 hasAuthorship W4384206830A5004278682 @default.
• W4384206830 hasAuthorship W4384206830A5009596285 @default.

• next