Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384206836> ?p ?o ?g. }
- W4384206836 abstract "ABSTRACT The pericentromeric heterochromatin of eukaryotic chromosomes primarily consists of abundant non-coding repeats known as satellite DNA, which promote accurate chromosome segregation and genome stability. During interphase, sequence-specific satellite DNA-binding proteins cluster repeats from multiple chromosomes into foci known as chromocenters, which function to encapsulate the entire genome in a single nucleus. Despite the pivotal role of satellite DNA-binding proteins and chromocenters in cellular function, the proteins associated with these repetitive sequences remains incompletely characterized. Here, we use quantitative mass spectrometry to characterize the chromocenter-associated proteome in Drosophila embryos, ovaries and testes using two satellite DNA-binding proteins, D1 and Prod, as baits. We identify nearly 500 interactions, including known heterochromatin-associated proteins as well as proteins previously unlinked to satellite DNA or chromocenters. Among these interactions, we find that multiple components of the transposon-silencing piRNA pathway are associated with chromocenters. Strikingly, we reveal that proper satellite DNA clustering plays a role in transgenerational transposon repression, such that mothers with disrupted chromocenters give rise to progeny that exhibit transposon de-repression, germ cell loss and gonadal atrophy. Overall, our study highlights a novel link between satellite DNA repeats and transposon repression and lays the foundation for a more comprehensive understanding of satellite DNA function across tissues." @default.
- W4384206836 created "2023-07-14" @default.
- W4384206836 creator A5028113739 @default.
- W4384206836 creator A5035740384 @default.
- W4384206836 creator A5042478049 @default.
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- W4384206836 creator A5084855553 @default.
- W4384206836 creator A5092464804 @default.
- W4384206836 creator A5092464805 @default.
- W4384206836 date "2023-07-12" @default.
- W4384206836 modified "2023-09-25" @default.
- W4384206836 title "Multi-tissue proteomics identifies a link between satellite DNA organization and transgenerational transposon repression in<i>Drosophila</i>" @default.
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