FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384207699> ?p ?o ?g. }

• W4384207699 endingPage "e0932" @default.
• W4384207699 startingPage "e0932" @default.
• W4384207699 abstract "OBJECTIVES: The Surviving Sepsis Campaign Guidelines recommend fluid administration of 30 cc/kg ideal body weight (IBW) for patients with sepsis and lactate greater than 4 mmol/L within 3 hours of identification. In this study, we explore the impact of fluid dose on lactate normalization, treatment cost, length of stay, and mortality in patients with lactate greater than 4. DESIGN: Multicenter retrospective observational study. SETTING: Eight-hospital urban healthcare system in Northeastern United States. PATIENTS: Patients with sepsis, initial lactate value greater than 4 mmol/L, and received appropriate antibiotics within 3 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We stratified patients into five groups based on the dose of fluid administered within 3 hours after sepsis identification. The groupings were less than 15 cc/kg IBW, 15.1–25 cc/kg IBW, 25.1–35 cc/kg IBW, 35.1–50 cc/kg IBW, and greater than 50 cc/kg IBW. We used the group that received a fluid dose of 25.1–35 cc/kg IBW, as a reference group. The mean age was 66 years, and 56% were male. Three hundred seventy-one (25%) received less than 15 cc/kg of IBW of crystalloid fluid, 278 (17%) received 15–25 cc/kg of IBW, 316 (21%) received 25.1–35 cc/kg of IBW, 319 (21%) received 35.1–50 cc/kg of IBW, and 207 (14%) received greater than 50 cc/kg of IBW. After multilinear regression, there was no significant difference in lactate normalization between the reference group and any of the other fluid groups. We also found no statistically significant difference in the observed/expected cost, or observed/expected length of stay, between the reference group and any of the other fluid groups. Mortality was higher among patients who received greater than 50 cc/kg IBW when compared to the recommended dose. CONCLUSIONS: In patients with sepsis and lactate value greater than 4 mmol/L, high or low fluid doses were not associated with better lactate clearance or patient outcomes. Greater than 50 cc/kg IBW dose of fluids within 3 hours is associated with higher mortality." @default.
• W4384207699 created "2023-07-14" @default.
• W4384207699 creator A5021635322 @default.
• W4384207699 creator A5036753394 @default.
• W4384207699 creator A5039186897 @default.
• W4384207699 creator A5055008966 @default.
• W4384207699 creator A5071845266 @default.
• W4384207699 creator A5089779635 @default.
• W4384207699 creator A5092464976 @default.
• W4384207699 date "2023-07-01" @default.
• W4384207699 modified "2023-09-27" @default.
• W4384207699 title "Evaluation of the Recommended 30 cc/kg Fluid Dose for Patients With Septic Shock and Hypoperfusion With Lactate Greater Than 4 mmol/L" @default.
• W4384207699 cites W2096883458 @default.
• W4384207699 cites W2102290891 @default.
• W4384207699 cites W2109728419 @default.
• W4384207699 cites W2144589352 @default.
• W4384207699 cites W2158623850 @default.
• W4384207699 cites W2177398380 @default.
• W4384207699 cites W2259009562 @default.
• W4384207699 cites W2398023930 @default.
• W4384207699 cites W2404681400 @default.
• W4384207699 cites W2465673526 @default.
• W4384207699 cites W2486721135 @default.
• W4384207699 cites W2799662739 @default.
• W4384207699 cites W2843416743 @default.
• W4384207699 cites W2891441581 @default.
• W4384207699 cites W2967525737 @default.
• W4384207699 cites W2989815630 @default.
• W4384207699 cites W3000726620 @default.
• W4384207699 cites W3008040894 @default.
• W4384207699 cites W3045454797 @default.
• W4384207699 cites W3108009337 @default.
• W4384207699 cites W3134887812 @default.
• W4384207699 cites W3154702719 @default.
• W4384207699 cites W3158989938 @default.
• W4384207699 doi "https://doi.org/10.1097/cce.0000000000000932" @default.
• W4384207699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37457917" @default.
• W4384207699 hasPublicationYear "2023" @default.
• W4384207699 type Work @default.
• W4384207699 citedByCount "0" @default.
• W4384207699 crossrefType "journal-article" @default.
• W4384207699 hasAuthorship W4384207699A5021635322 @default.
• W4384207699 hasAuthorship W4384207699A5036753394 @default.
• W4384207699 hasAuthorship W4384207699A5039186897 @default.
• W4384207699 hasAuthorship W4384207699A5055008966 @default.
• W4384207699 hasAuthorship W4384207699A5071845266 @default.
• W4384207699 hasAuthorship W4384207699A5089779635 @default.
• W4384207699 hasAuthorship W4384207699A5092464976 @default.
• W4384207699 hasBestOaLocation W43842076991 @default.
• W4384207699 hasConcept C126322002 @default.
• W4384207699 hasConcept C140793950 @default.
• W4384207699 hasConcept C146957229 @default.
• W4384207699 hasConcept C2777628635 @default.
• W4384207699 hasConcept C2778384902 @default.
• W4384207699 hasConcept C71924100 @default.
• W4384207699 hasConcept C86803240 @default.
• W4384207699 hasConceptScore W4384207699C126322002 @default.
• W4384207699 hasConceptScore W4384207699C140793950 @default.
• W4384207699 hasConceptScore W4384207699C146957229 @default.
• W4384207699 hasConceptScore W4384207699C2777628635 @default.
• W4384207699 hasConceptScore W4384207699C2778384902 @default.
• W4384207699 hasConceptScore W4384207699C71924100 @default.
• W4384207699 hasConceptScore W4384207699C86803240 @default.
• W4384207699 hasIssue "7" @default.
• W4384207699 hasLocation W43842076991 @default.
• W4384207699 hasLocation W43842076992 @default.
• W4384207699 hasLocation W43842076993 @default.
• W4384207699 hasLocation W43842076994 @default.
• W4384207699 hasOpenAccess W4384207699 @default.
• W4384207699 hasPrimaryLocation W43842076991 @default.
• W4384207699 hasRelatedWork W173747762 @default.
• W4384207699 hasRelatedWork W2065102252 @default.
• W4384207699 hasRelatedWork W2079275168 @default.
• W4384207699 hasRelatedWork W2143279052 @default.
• W4384207699 hasRelatedWork W2408010109 @default.
• W4384207699 hasRelatedWork W2742862736 @default.
• W4384207699 hasRelatedWork W2835571264 @default.
• W4384207699 hasRelatedWork W2996119114 @default.
• W4384207699 hasRelatedWork W4386518367 @default.
• W4384207699 hasRelatedWork W51223972 @default.
• W4384207699 hasVolume "5" @default.
• W4384207699 isParatext "false" @default.
• W4384207699 isRetracted "false" @default.
• W4384207699 workType "article" @default.