FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384207726> ?p ?o ?g. }

• W4384207726 endingPage "106230" @default.
• W4384207726 startingPage "106230" @default.
• W4384207726 abstract "Multiple sclerosis (MS) is a complex chronic disease with an unknown etiology. It is considered an inflammatory demyelinating and neurodegenerative disorder of the central nervous system (CNS) characterized, in most cases, by an unpredictable onset of relapse and remission phases. The disease generally starts in subjects under 40; it has a higher incidence in women and is described as a multifactorial disorder due to the interaction between genetic and environmental risk factors. Unfortunately, there is currently no definitive cure for MS. Still, therapies can modify the disease's natural history, reducing the relapse rate and slowing the progression of the disease or managing symptoms. The limited access to human CNS tissue slows down. It limits the progression of research on MS. This limit has been partially overcome over the years by developing various experimental models to study this disease. Animal models of autoimmune demyelination, such as experimental autoimmune encephalomyelitis (EAE) and viral and toxin or transgenic MS models, represent the most significant part of MS research approaches. These models have now been complemented by ex vivo studies, using organotypic brain slice cultures and in vitro, through induced Pluripotent Stem cells (iPSCs). We will discuss which clinical features of the disorders might be reproduced and investigated in vivo, ex vivo, and in vitro in models commonly used in MS research to understand the processes behind the neuropathological events occurring in the CNS of MS patients. The primary purpose of this review is to give the reader a global view of the main paradigms used in MS research, spacing from the classical animal models to transgenic mice and 2D and 3D cultures." @default.
• W4384207726 created "2023-07-14" @default.
• W4384207726 creator A5023238625 @default.
• W4384207726 creator A5031577729 @default.
• W4384207726 creator A5037638324 @default.
• W4384207726 creator A5043507370 @default.
• W4384207726 creator A5054978659 @default.
• W4384207726 creator A5066081782 @default.
• W4384207726 creator A5076289110 @default.
• W4384207726 creator A5088425753 @default.
• W4384207726 creator A5092464980 @default.
• W4384207726 date "2023-08-01" @default.
• W4384207726 modified "2023-10-03" @default.
• W4384207726 title "An overall view of the most common experimental models for multiple sclerosis" @default.
• W4384207726 cites W1491807079 @default.
• W4384207726 cites W1523338791 @default.
• W4384207726 cites W1542595036 @default.
• W4384207726 cites W1547732107 @default.
• W4384207726 cites W1553161314 @default.
• W4384207726 cites W1555113073 @default.
• W4384207726 cites W1560339503 @default.
• W4384207726 cites W1571275573 @default.
• W4384207726 cites W1577354978 @default.
• W4384207726 cites W1590451328 @default.
• W4384207726 cites W1597647646 @default.
• W4384207726 cites W1600103538 @default.
• W4384207726 cites W1607206274 @default.
• W4384207726 cites W1619327403 @default.
• W4384207726 cites W1679478585 @default.
• W4384207726 cites W1692776653 @default.
• W4384207726 cites W1769453339 @default.
• W4384207726 cites W1818774265 @default.
• W4384207726 cites W186713564 @default.
• W4384207726 cites W1870113949 @default.
• W4384207726 cites W1901712533 @default.
• W4384207726 cites W1964421053 @default.
• W4384207726 cites W1964885806 @default.
• W4384207726 cites W1965608155 @default.
• W4384207726 cites W1966600053 @default.
• W4384207726 cites W1966880041 @default.
• W4384207726 cites W1967493950 @default.
• W4384207726 cites W1967724489 @default.
• W4384207726 cites W1968846399 @default.
• W4384207726 cites W1969693550 @default.
• W4384207726 cites W1971642548 @default.
• W4384207726 cites W1973101671 @default.
• W4384207726 cites W1974900192 @default.
• W4384207726 cites W1975111987 @default.
• W4384207726 cites W1976307335 @default.
• W4384207726 cites W1977056631 @default.
• W4384207726 cites W1979049647 @default.
• W4384207726 cites W1979312185 @default.
• W4384207726 cites W1984320937 @default.
• W4384207726 cites W1990980415 @default.
• W4384207726 cites W1991361780 @default.
• W4384207726 cites W1991883207 @default.
• W4384207726 cites W1992153265 @default.
• W4384207726 cites W1992876317 @default.
• W4384207726 cites W1995565139 @default.
• W4384207726 cites W1995704392 @default.
• W4384207726 cites W1996630186 @default.
• W4384207726 cites W1996932689 @default.
• W4384207726 cites W1997019576 @default.
• W4384207726 cites W1998041024 @default.
• W4384207726 cites W2000631468 @default.
• W4384207726 cites W2001037553 @default.
• W4384207726 cites W2002436119 @default.
• W4384207726 cites W2003896813 @default.
• W4384207726 cites W2004973774 @default.
• W4384207726 cites W2005868265 @default.
• W4384207726 cites W2006171191 @default.
• W4384207726 cites W2007360114 @default.
• W4384207726 cites W2008188679 @default.
• W4384207726 cites W2010315866 @default.
• W4384207726 cites W2010418081 @default.
• W4384207726 cites W2011119843 @default.
• W4384207726 cites W2013148805 @default.
• W4384207726 cites W2013481339 @default.
• W4384207726 cites W2013932229 @default.
• W4384207726 cites W2014820034 @default.
• W4384207726 cites W2015371338 @default.
• W4384207726 cites W2015847142 @default.
• W4384207726 cites W2017718617 @default.
• W4384207726 cites W2018027744 @default.
• W4384207726 cites W2018226150 @default.
• W4384207726 cites W2018286352 @default.
• W4384207726 cites W2018456133 @default.
• W4384207726 cites W2019379391 @default.
• W4384207726 cites W2021506523 @default.
• W4384207726 cites W2022215531 @default.
• W4384207726 cites W2022853021 @default.
• W4384207726 cites W2029232806 @default.
• W4384207726 cites W2030742459 @default.
• W4384207726 cites W2031195065 @default.
• W4384207726 cites W2033322963 @default.
• W4384207726 cites W2043264873 @default.
• W4384207726 cites W2044058948 @default.
• W4384207726 cites W2044282009 @default.

• next