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- W4384207998 abstract "Acute promyelocytic leukemia (APL) is an acute myeloid leukemia (AML) with a specific fusion gene target, PML-RARα fusion gene (PML-RARα), which is formed by the translocation of chromosomes 15 and 17. Detection of PML-RARα is the most reliable parameter for the diagnosis, treatment adjustment, efficacy evaluation, prognosis analysis and relapse prediction of APL. In this study, a novel biosensor was constructed for rapid enzyme-free detection of PML/RARα using DNAzyme and carbon dots/cobalt oxhydroxide nanosheet complexs (CDs/CoOOH). In the detection system, the separated DNAzyme could specifically recognize and bind the PML-RARα to form a complete DNAzyme for shearing hairpin probe (HP), then generate trigger, which was the first signal amplification. Then, trigger could hybridize with the capture probe (CP) anchored to streptavidin (SA) modified microplate as well as fluorescence quenching signal probe ([email protected]/CoOOH). Finally, ascorbic acid (AA) was added to decompose CoOOH and the fluorescence of CDs was released, which was the second signal amplification. Through the dual signal amplification of DNAzyme and CDs/CoOOH, PML-RARα could be detected quickly and sensitively, which overcame the limitation of protein enzyme in traditional fluorescence method, showing potential clinical application value in the diagnosis and treatment of leukemia." @default.
- W4384207998 created "2023-07-14" @default.
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- W4384207998 date "2023-10-01" @default.
- W4384207998 modified "2023-09-26" @default.
- W4384207998 title "Enzyme-free dual amplification biosensor based on functional nucleic acid and CDs/CoOOH for detection of leukemia fusion gene" @default.
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- W4384207998 doi "https://doi.org/10.1016/j.aca.2023.341623" @default.
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