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- W4384208021 abstract "To evaluate for the presence, severity, and type of exudation at each study visit for a subgroup of patients with neovascular age-related macular degeneration (nAMD) from the Archway and Portal trials.Retrospective analysis of prospectively obtained data METHODS: Spectral domain-optical coherence tomography scans from each study visit of 44 patients from the Port Delivery System (PDS) arm and 32 patients from the monthly injection arm of Archway were evaluated and composites of horizontal scans through the fovea were created. Each composite was graded for the presence, type, and severity of exudation and impact on best corrected visual acuity (BCVA).After PDS implantation, 20 of 44 eyes (45%) never showed any exudation in the fovea, 2 (5%) never showed exudation in the fovea but had several missed visits, while 15 (34%), 3 (7%), and 4 (9%) showed mild, moderate, or severe exudation at 1 or more study visits. When exudation was present, it was most commonly subretinal fluid (50%). Of 32 patients randomized to monthly injections, 15 (47%) had no exudation in the fovea during monthly injections or after PDS implantation. Fluctuation of exudation in the fovea over time was seen in some patients after PDS implantation or during monthly injections with little or no identifiable impact on BCVA. In the 7 eyes with moderate or severe exudation in the fovea after PDS implantation, final vision was good in 5 (20/25 in 3, 20/40 in 1, 20/50 in 1) and 2 had reduced vision from submacular hemorrhage.The PDS provides excellent control of exudation in the fovea in patients with nAMD and when exudation occurs, it often resolves without a negative impact on vision." @default.
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- W4384208021 date "2023-07-01" @default.
- W4384208021 modified "2023-09-25" @default.
- W4384208021 title "Exudation in Patients with Neovascular Age-Related Macular Degeneration Treated with the Port Delivery System or Monthly Injections" @default.
- W4384208021 doi "https://doi.org/10.1016/j.ajo.2023.07.003" @default.
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