Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384208077> ?p ?o ?g. }
- W4384208077 endingPage "110681" @default.
- W4384208077 startingPage "110681" @default.
- W4384208077 abstract "This study conducted a high-throughput sequencing analysis of the T- and B- repertoires in the newly diagnosed GDM patients and evaluated the association between abnormal adaptive immunity and GDM. The unique TCR CDR3 clonotypes were mildly decreased in GDM patients, and the similarity of TCR V-J distributions was higher in the GDM group. Moreover, the usages of the V gene and V-J pair and the frequency distributions of some CDR3 amino acids (AAs) both in BCR and TCR were significantly different between groups. Moreover, the cytokines including IL-4, IL-6, IFN-γ and IL-17A were synchronously elevated in the GDM cases. Our findings provide a comprehensive view of BCR and TCR repertoires at newly diagnosed GDM patients, revealing the mild reduction in unique TCRB CDR3 sequences and slight alteration of the V gene, V-J combination and CDR3 (AA) usages of BCR and TCR. This work provides deep insight into the mechanism of maternal adaptive immunity in GDM and provides novel diagnostic biomarkers and potential immunotherapy targets for GDM." @default.
- W4384208077 created "2023-07-14" @default.
- W4384208077 creator A5018263002 @default.
- W4384208077 creator A5029972519 @default.
- W4384208077 creator A5032683472 @default.
- W4384208077 creator A5034976685 @default.
- W4384208077 creator A5041983007 @default.
- W4384208077 creator A5063174892 @default.
- W4384208077 creator A5065388588 @default.
- W4384208077 creator A5068112395 @default.
- W4384208077 creator A5089559870 @default.
- W4384208077 date "2023-09-01" @default.
- W4384208077 modified "2023-10-14" @default.
- W4384208077 title "Comprehensive landscape of the T and B-cell repertoires of newly diagnosed gestational diabetes mellitus" @default.
- W4384208077 cites W1509989355 @default.
- W4384208077 cites W1924919590 @default.
- W4384208077 cites W1960601565 @default.
- W4384208077 cites W1963745142 @default.
- W4384208077 cites W1972251954 @default.
- W4384208077 cites W1981165130 @default.
- W4384208077 cites W1995117496 @default.
- W4384208077 cites W2031213748 @default.
- W4384208077 cites W2046169514 @default.
- W4384208077 cites W2063442682 @default.
- W4384208077 cites W2092134310 @default.
- W4384208077 cites W2111971110 @default.
- W4384208077 cites W2120317645 @default.
- W4384208077 cites W2132690665 @default.
- W4384208077 cites W2152014155 @default.
- W4384208077 cites W2152288668 @default.
- W4384208077 cites W2578150941 @default.
- W4384208077 cites W2607019199 @default.
- W4384208077 cites W2622094211 @default.
- W4384208077 cites W2744804690 @default.
- W4384208077 cites W2763175706 @default.
- W4384208077 cites W2766388580 @default.
- W4384208077 cites W2769821087 @default.
- W4384208077 cites W2793773213 @default.
- W4384208077 cites W2800537826 @default.
- W4384208077 cites W2801991666 @default.
- W4384208077 cites W2890297931 @default.
- W4384208077 cites W2892092991 @default.
- W4384208077 cites W2908667389 @default.
- W4384208077 cites W2980381505 @default.
- W4384208077 cites W3034922157 @default.
- W4384208077 cites W3083146163 @default.
- W4384208077 cites W3115930546 @default.
- W4384208077 cites W3121912006 @default.
- W4384208077 cites W3133798093 @default.
- W4384208077 cites W3149957333 @default.
- W4384208077 cites W3185560091 @default.
- W4384208077 cites W3197477722 @default.
- W4384208077 cites W3213135337 @default.
- W4384208077 cites W4200157620 @default.
- W4384208077 cites W4245248161 @default.
- W4384208077 cites W4280605000 @default.
- W4384208077 doi "https://doi.org/10.1016/j.ygeno.2023.110681" @default.
- W4384208077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37453476" @default.
- W4384208077 hasPublicationYear "2023" @default.
- W4384208077 type Work @default.
- W4384208077 citedByCount "0" @default.
- W4384208077 crossrefType "journal-article" @default.
- W4384208077 hasAuthorship W4384208077A5018263002 @default.
- W4384208077 hasAuthorship W4384208077A5029972519 @default.
- W4384208077 hasAuthorship W4384208077A5032683472 @default.
- W4384208077 hasAuthorship W4384208077A5034976685 @default.
- W4384208077 hasAuthorship W4384208077A5041983007 @default.
- W4384208077 hasAuthorship W4384208077A5063174892 @default.
- W4384208077 hasAuthorship W4384208077A5065388588 @default.
- W4384208077 hasAuthorship W4384208077A5068112395 @default.
- W4384208077 hasAuthorship W4384208077A5089559870 @default.
- W4384208077 hasBestOaLocation W43842080771 @default.
- W4384208077 hasConcept C104317684 @default.
- W4384208077 hasConcept C19317047 @default.
- W4384208077 hasConcept C193419808 @default.
- W4384208077 hasConcept C203014093 @default.
- W4384208077 hasConcept C2776090121 @default.
- W4384208077 hasConcept C2779234561 @default.
- W4384208077 hasConcept C2779341262 @default.
- W4384208077 hasConcept C2779434492 @default.
- W4384208077 hasConcept C43907098 @default.
- W4384208077 hasConcept C46973012 @default.
- W4384208077 hasConcept C54355233 @default.
- W4384208077 hasConcept C70721500 @default.
- W4384208077 hasConcept C86803240 @default.
- W4384208077 hasConcept C8891405 @default.
- W4384208077 hasConceptScore W4384208077C104317684 @default.
- W4384208077 hasConceptScore W4384208077C19317047 @default.
- W4384208077 hasConceptScore W4384208077C193419808 @default.
- W4384208077 hasConceptScore W4384208077C203014093 @default.
- W4384208077 hasConceptScore W4384208077C2776090121 @default.
- W4384208077 hasConceptScore W4384208077C2779234561 @default.
- W4384208077 hasConceptScore W4384208077C2779341262 @default.
- W4384208077 hasConceptScore W4384208077C2779434492 @default.
- W4384208077 hasConceptScore W4384208077C43907098 @default.
- W4384208077 hasConceptScore W4384208077C46973012 @default.
- W4384208077 hasConceptScore W4384208077C54355233 @default.
- W4384208077 hasConceptScore W4384208077C70721500 @default.