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• W4384274017 abstract "Introduction: Leprosy is one of the oldest diseases of humanity and still one of the most neglected. The coronavirus disease 2019 (COVID-19) pandemic has caused several entities to be concerned about the impact of the disease caused by severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) in patients previously affected by other comorbidities.We report a case of leprosy neuritis due to COVID-19. Case: A 39-year-old male patient was diagnosed with borderline-lepromatous leprosy in 2015. On physical examination, he presented nerve thickening and an asymmetric multiple mononeuropathy on electroneuromyography (ENMG). He was treated with Rifampicin-Ofloxacin-Minocycline regimen for two years, with no sequelae. In 2021, he started with pain and paresthesia in the plantar and dorsal regions of the feet. He evolved with difficulty in walking and physical examination showed diffuse paresthesia and evident allodynia on the soles and dorsum of the feet, bilaterally. The patient did not present proximal muscle weakness, nor impairment of deep osteotendinous reflexes. Cerebrospinal fluid analysis was normal. About fifteen days prior to this, he was detected with COVID-19, manifested in a mild way, requiring only symptomatic medications. The ENMG showed signs of an asymmetric multiple mononeuropathy, predominantly axonal and sensorial, of severe intensity, with multiple associated focal myelin impairments, such as temporal dispersion. There were a severe impairment of the left ulnar, left fibular and tibial nerves. He was then diagnosed with type 1 leprosy reaction and underwent monthly pulse therapy with methylprednisolone, with an important clinical response. Discussion: Since the beginning of COVID-19, the possibility of an interaction between SARS-CoV-2 and Mycobacterium leprae has been raised, especially due to the immunological component of both diseases. Some authors have warned of the possibility of the influence of COVID-19, especially during its inflammatory phase, in triggering leprosy reactions, since infections are risk factors for their occurrence. Post-infectious reactional episodes always represent a challenge in clinical practice, as they are the main cause of disability and maintenance of leprosy-related stigma. Conclusion: The case reports a significant neurological impairment in a patient previously diagnosed with leprosy after SARS-CoV-2 infection. The importance of verifying possible post-pandemic impacts on historically neglected pathologies is highlighted." @default.
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• W4384274017 date "2023-01-01" @default.
• W4384274017 modified "2023-10-11" @default.
• W4384274017 title "Leprosy neuritis due to COVID-19: a case report" @default.
• W4384274017 doi "https://doi.org/10.5327/1516-3180.141s1.776" @default.
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