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- W4384274251 abstract "High-temperature stress caused by global climate change poses a significant threat to marine ectotherms. This study investigated the role of protein phosphorylation modifications in the molecular regulation network under heat stress in oysters, which are representative intertidal organisms that experience considerable temperature changes. Firstly, the study compared the extent of thermal damage between two congeneric oyster species, the relative heat-tolerant Crassostrea angulata (C. angulata) and heat-sensitive Crassostrea gigas (C. gigas), under sublethal temperature (37 °C) for 12 h, using various physiological and biochemical methods. Subsequently, the comparative proteomic and phosphoproteomic analyses revealed that high-temperature considerably regulated signal transduction, energy metabolism, protein synthesis, cell survival and apoptosis, and cytoskeleton remodeling through phosphorylation modifications of related receptors and kinases. Furthermore, the protein kinase A, mitogen-activated protein kinase 1, tyrosine-protein kinase Src, and serine/threonine kinase AKT, exhibiting differential phosphorylation modification patterns, were identified as hub regulators that may enhance glycolysis and TCA cycle to increase the energy supply, distribute protein synthesis, inhibit Caspase-dependent apoptosis activated by endogenous mitochondrial cytochrome release and maintain cytoskeletal stability, ultimately shaping the higher thermal resistance of C. angulata. This study represents the first investigation of protein phosphorylation dynamics in marine invertebrates under heat stress, reveals the molecular mechanisms underlying the differential thermal responses between two Crassostrea oysters at the phosphorylation level, and provides new insights into understanding phosphorylation-mediated molecular responses in marine organisms during environmental changes and predicting the adaptive potential in the context of global warming." @default.
- W4384274251 created "2023-07-15" @default.
- W4384274251 creator A5004740349 @default.
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- W4384274251 creator A5063099341 @default.
- W4384274251 creator A5075496753 @default.
- W4384274251 creator A5091867277 @default.
- W4384274251 date "2023-09-01" @default.
- W4384274251 modified "2023-10-17" @default.
- W4384274251 title "Comparative proteomic and phosphoproteomic analysis reveals differential heat response mechanism in two congeneric oyster species" @default.
- W4384274251 cites W1934159751 @default.
- W4384274251 cites W1964810666 @default.
- W4384274251 cites W1966931906 @default.
- W4384274251 cites W1970453709 @default.
- W4384274251 cites W1972812075 @default.
- W4384274251 cites W1976598159 @default.
- W4384274251 cites W1977910682 @default.
- W4384274251 cites W1982639605 @default.
- W4384274251 cites W1991902515 @default.
- W4384274251 cites W1992425314 @default.
- W4384274251 cites W1993904291 @default.
- W4384274251 cites W1998889146 @default.
- W4384274251 cites W2000042427 @default.
- W4384274251 cites W2004188992 @default.
- W4384274251 cites W2008294451 @default.
- W4384274251 cites W2010516785 @default.
- W4384274251 cites W2010623095 @default.
- W4384274251 cites W2015396179 @default.
- W4384274251 cites W2015717646 @default.
- W4384274251 cites W2017151000 @default.
- W4384274251 cites W2018595142 @default.
- W4384274251 cites W2019750161 @default.
- W4384274251 cites W2022840517 @default.
- W4384274251 cites W2026345779 @default.
- W4384274251 cites W2035618305 @default.
- W4384274251 cites W2035823944 @default.
- W4384274251 cites W2037045758 @default.
- W4384274251 cites W2042745266 @default.
- W4384274251 cites W2044868069 @default.
- W4384274251 cites W2046070973 @default.
- W4384274251 cites W2047143769 @default.
- W4384274251 cites W2047759567 @default.
- W4384274251 cites W2050774616 @default.
- W4384274251 cites W2050850970 @default.
- W4384274251 cites W2051097810 @default.
- W4384274251 cites W2053782496 @default.
- W4384274251 cites W2061903251 @default.
- W4384274251 cites W2062547838 @default.
- W4384274251 cites W2070159387 @default.
- W4384274251 cites W2072929814 @default.
- W4384274251 cites W2073802968 @default.
- W4384274251 cites W2074138980 @default.
- W4384274251 cites W2079437966 @default.
- W4384274251 cites W2081474005 @default.
- W4384274251 cites W2081920342 @default.
- W4384274251 cites W2087216031 @default.
- W4384274251 cites W2092468458 @default.
- W4384274251 cites W2092884086 @default.
- W4384274251 cites W2094064830 @default.
- W4384274251 cites W2094093891 @default.
- W4384274251 cites W2096405334 @default.
- W4384274251 cites W2106823075 @default.
- W4384274251 cites W2108823783 @default.
- W4384274251 cites W2109577572 @default.
- W4384274251 cites W2109972174 @default.
- W4384274251 cites W2122062261 @default.
- W4384274251 cites W2125717491 @default.
- W4384274251 cites W2125756459 @default.
- W4384274251 cites W2129936691 @default.
- W4384274251 cites W2137383307 @default.
- W4384274251 cites W2138319716 @default.
- W4384274251 cites W2139270239 @default.
- W4384274251 cites W2141693735 @default.
- W4384274251 cites W2142083272 @default.
- W4384274251 cites W2142533439 @default.
- W4384274251 cites W2144065167 @default.
- W4384274251 cites W2144285975 @default.
- W4384274251 cites W2144654901 @default.
- W4384274251 cites W2146318623 @default.
- W4384274251 cites W2149104273 @default.
- W4384274251 cites W2149281930 @default.
- W4384274251 cites W2152155752 @default.
- W4384274251 cites W2153775161 @default.
- W4384274251 cites W2157283432 @default.
- W4384274251 cites W2159675211 @default.
- W4384274251 cites W2160276294 @default.
- W4384274251 cites W2163117716 @default.
- W4384274251 cites W2164836249 @default.
- W4384274251 cites W2168597617 @default.
- W4384274251 cites W2169763871 @default.
- W4384274251 cites W2230237375 @default.
- W4384274251 cites W2331692240 @default.
- W4384274251 cites W2520656712 @default.
- W4384274251 cites W2528431093 @default.
- W4384274251 cites W2729288479 @default.
- W4384274251 cites W2750144881 @default.