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• W4384277013 abstract "Platelets are necessary for maintaining haemostasis. Separately, platelets are important for the propagation of inflammation during the host immune response against infection. The activation of platelets also causes inappropriate inflammation in various disease pathologies, often in the absence of changes to haemostasis. The separate functions of platelets during inflammation compared with haemostasis are therefore varied and this will be reflected in distinct pathways of activation. The activation of platelets by the nucleotide adenosine diphosphate (ADP) acting on P2Y1 and P2Y12 receptors is important for the development of platelet thrombi during haemostasis. However, P2Y1 stimulation of platelets is also important during the inflammatory response and paradoxically in scenarios where no changes to haemostasis and platelet aggregation occur. In these events, Rho-GTPase signalling, rather than the canonical phospholipase Cβ (PLCβ) signalling pathway, is necessary. We describe our current understanding of these differences, reflecting on recent advances in knowledge of P2Y1 structure, and the possibility of biased agonism occurring from activation via other endogenous nucleotides compared with ADP. Knowledge arising from these different pathways of P2Y1 stimulation of platelets during inflammation compared with haemostasis may help therapeutic control of platelet function during inflammation or infection, while preserving essential haemostasis." @default.
• W4384277013 created "2023-07-15" @default.
• W4384277013 creator A5006583391 @default.
• W4384277013 creator A5029725332 @default.
• W4384277013 creator A5040150802 @default.
• W4384277013 creator A5076475814 @default.
• W4384277013 date "2023-08-02" @default.
• W4384277013 modified "2023-09-26" @default.
• W4384277013 title "Exploring bias in platelet P2Y₁ signalling: host defence versus haemostasis." @default.
• W4384277013 cites W113835883 @default.
• W4384277013 cites W130048390 @default.
• W4384277013 cites W1556070936 @default.
• W4384277013 cites W1567363998 @default.
• W4384277013 cites W1602132889 @default.
• W4384277013 cites W1602498852 @default.
• W4384277013 cites W1657177414 @default.
• W4384277013 cites W1847464474 @default.
• W4384277013 cites W1875252081 @default.
• W4384277013 cites W1967933675 @default.
• W4384277013 cites W1969358114 @default.
• W4384277013 cites W1971004719 @default.
• W4384277013 cites W1973473972 @default.
• W4384277013 cites W1973868069 @default.
• W4384277013 cites W1975829169 @default.
• W4384277013 cites W1976954262 @default.
• W4384277013 cites W1978264469 @default.
• W4384277013 cites W1978605633 @default.
• W4384277013 cites W1979412100 @default.
• W4384277013 cites W1985927027 @default.
• W4384277013 cites W1987062630 @default.
• W4384277013 cites W1987174800 @default.
• W4384277013 cites W1988121084 @default.
• W4384277013 cites W1989382032 @default.
• W4384277013 cites W1994370838 @default.
• W4384277013 cites W1995601334 @default.
• W4384277013 cites W1998402796 @default.
• W4384277013 cites W2004794419 @default.
• W4384277013 cites W2005464779 @default.
• W4384277013 cites W2007808963 @default.
• W4384277013 cites W2008971450 @default.
• W4384277013 cites W2009303270 @default.
• W4384277013 cites W2011137086 @default.
• W4384277013 cites W2011823999 @default.
• W4384277013 cites W2014673121 @default.
• W4384277013 cites W2014924961 @default.
• W4384277013 cites W2016217548 @default.
• W4384277013 cites W2017021371 @default.
• W4384277013 cites W2018863750 @default.
• W4384277013 cites W2020043514 @default.
• W4384277013 cites W2021545721 @default.
• W4384277013 cites W2024315313 @default.
• W4384277013 cites W2030569295 @default.
• W4384277013 cites W2033250157 @default.
• W4384277013 cites W2034643457 @default.
• W4384277013 cites W2035054244 @default.
• W4384277013 cites W2035927398 @default.
• W4384277013 cites W2036146605 @default.
• W4384277013 cites W2038765360 @default.
• W4384277013 cites W2045715055 @default.
• W4384277013 cites W2046152872 @default.
• W4384277013 cites W2047733446 @default.
• W4384277013 cites W2048443303 @default.
• W4384277013 cites W2052328463 @default.
• W4384277013 cites W2057599460 @default.
• W4384277013 cites W2061541664 @default.
• W4384277013 cites W2062035096 @default.
• W4384277013 cites W2062910590 @default.
• W4384277013 cites W2064297593 @default.
• W4384277013 cites W2065053712 @default.
• W4384277013 cites W2065541624 @default.
• W4384277013 cites W2068244483 @default.
• W4384277013 cites W2069143365 @default.
• W4384277013 cites W2075124455 @default.
• W4384277013 cites W2076842345 @default.
• W4384277013 cites W2079362390 @default.
• W4384277013 cites W2081045555 @default.
• W4384277013 cites W2081359702 @default.
• W4384277013 cites W2081758042 @default.
• W4384277013 cites W2082075991 @default.
• W4384277013 cites W2087675462 @default.
• W4384277013 cites W2088515613 @default.
• W4384277013 cites W2096539359 @default.
• W4384277013 cites W2103746902 @default.
• W4384277013 cites W2104575856 @default.
• W4384277013 cites W2108710159 @default.
• W4384277013 cites W2111412007 @default.
• W4384277013 cites W2122424184 @default.
• W4384277013 cites W2128978853 @default.
• W4384277013 cites W2133991763 @default.
• W4384277013 cites W2134092694 @default.
• W4384277013 cites W2134723230 @default.
• W4384277013 cites W2136113015 @default.
• W4384277013 cites W2139812868 @default.
• W4384277013 cites W2149371927 @default.
• W4384277013 cites W2150752051 @default.
• W4384277013 cites W2158574796 @default.
• W4384277013 cites W2162289305 @default.
• W4384277013 cites W2166078848 @default.
• W4384277013 cites W2169584153 @default.
• W4384277013 cites W2170420569 @default.

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