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- W4384277234 abstract "Currently, multidrug combinations are often used clinically to improve the efficacy of oncology chemotherapy, but multidrug combinations often lead to multidrug resistance and decreased performance, resulting in more severe side effects than monotherapy. Therefore, sequential drug release strategies in time and space as well as nanocarriers that respond to the tumor microenvironment have been developed. First, the advantage of the sequential release strategy is that it can load multiple drugs simultaneously to meet their spatiotemporal requirements and stability, thus exerting synergistic effects of two or more drugs. Second, in some cases, sequential drug delivery of different molecular targets can improve the sensitivity of cancer cells to drugs, control the metabolism of cancer cells, and remodel tumor vasculature. Finally, some drug combinations with built-in release control are used for sequential administration. This paper focuses on the use of nanotechnology and built-in control device to construct drug delivery carriers with different stimulation responses, thus achieving the sequential release of drugs. Therefore, the nano-sequential delivery carrier provides a new idea and platform for the therapeutic effect of various drugs and the synergistic effect among the drugs." @default.
- W4384277234 created "2023-07-15" @default.
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- W4384277234 date "2023-07-13" @default.
- W4384277234 modified "2023-09-25" @default.
- W4384277234 title "The application of nanodrug delivery system with sequential drug release strategies in cancer therapy" @default.
- W4384277234 doi "https://doi.org/10.2174/1567201820666230713164811" @default.
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