FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384277474> ?p ?o ?g. }

• W4384277474 endingPage "112254" @default.
• W4384277474 startingPage "112254" @default.
• W4384277474 abstract "Biological markers contribute to the precise intervention across the continuum of frailty severity. Few studies have explored the advantages of biological markers collected as part of primary care data among community-dwelling older adult population and controversy remains regarding the classic biological markers for frailty.We recruited a total of 8791 adults with a mean age of 71.95 years who met the inclusion and exclusion criteria in Guancheng District and Dalang Town, Dongguan, China. Frailty was assessed by a Chinese frailty evaluation scale. Frailty status was classified with 33-item modified frailty index and latent class analysis was applied to explore the latent classes (subtypes) of frailty. We measured biological markers on blood samples collected. We identify association between specific biological markers or patterns and frailty by logistic regression and association rule mining (ARM) based on the Apriori algorithm.Multivariable analysis of our data showed that an elevated white blood cell (WBC) count and high cholesterol (CHOL) level were associated with pre-frailty (adjusted odds ratio [aOR] = 1.231, 95 % confidence interval [CI] = 1.009-1.501; aOR = 0.703, 95 % CI = 0.623-0.793) and frailty (aOR = 1.500, 95 % CI = 1.130-1.993; aOR = 0.561, 95 % CI = 0.461-0.684) compared with the normal groups. Importantly, significantly high level of CHOL was associated with a lower risk of four frailty subtypes compared with relatively healthy participants with the most power of association in the multi-frail group (aOR = 0.182, 95 % CI = 0.086-0.386). Based on ARM technique to develop correlation analysis to identify important high-risk clusters among older adult transitions from non-frail to frailty, patterns for normal level of CHOL co-occurred with an elevated creatinine (CREA) level have a significant association with the risk of frailty (aOR = 7.787, 95 % CI = 1.978-30.648) after adjusting for targeted confounders.Our study highlights the correlation between classic biological markers, especially CHOL and frailty status and subtypes among community-dwelling older adult, in the primary care setting. Further large-scale prospective studies are still needed to confirm the role of classic biological markers in frailty." @default.
• W4384277474 created "2023-07-15" @default.
• W4384277474 creator A5006053179 @default.
• W4384277474 creator A5034694275 @default.
• W4384277474 creator A5043166126 @default.
• W4384277474 creator A5043503596 @default.
• W4384277474 creator A5048052603 @default.
• W4384277474 creator A5052861471 @default.
• W4384277474 creator A5056248574 @default.
• W4384277474 creator A5056302980 @default.
• W4384277474 creator A5086295794 @default.
• W4384277474 creator A5088003514 @default.
• W4384277474 creator A5092468517 @default.
• W4384277474 date "2023-09-01" @default.
• W4384277474 modified "2023-10-14" @default.
• W4384277474 title "Cholesterol alone or in combination is associated with frailty among community-dwelling older adults: A cross-sectional study" @default.
• W4384277474 cites W1581404153 @default.
• W4384277474 cites W1891508925 @default.
• W4384277474 cites W1973403246 @default.
• W4384277474 cites W1975412844 @default.
• W4384277474 cites W2020989348 @default.
• W4384277474 cites W2039221207 @default.
• W4384277474 cites W2098726460 @default.
• W4384277474 cites W2098966372 @default.
• W4384277474 cites W2099236256 @default.
• W4384277474 cites W2103809032 @default.
• W4384277474 cites W2104859015 @default.
• W4384277474 cites W2107794933 @default.
• W4384277474 cites W2118007883 @default.
• W4384277474 cites W2129700906 @default.
• W4384277474 cites W2148573574 @default.
• W4384277474 cites W2164186760 @default.
• W4384277474 cites W2166902802 @default.
• W4384277474 cites W2167921194 @default.
• W4384277474 cites W2346440068 @default.
• W4384277474 cites W2551541514 @default.
• W4384277474 cites W2576029872 @default.
• W4384277474 cites W2768425418 @default.
• W4384277474 cites W2770907544 @default.
• W4384277474 cites W2781122472 @default.
• W4384277474 cites W2798077780 @default.
• W4384277474 cites W2807752776 @default.
• W4384277474 cites W2888875665 @default.
• W4384277474 cites W2889139974 @default.
• W4384277474 cites W2897858769 @default.
• W4384277474 cites W2952786964 @default.
• W4384277474 cites W2979340990 @default.
• W4384277474 cites W2986360926 @default.
• W4384277474 cites W3000408724 @default.
• W4384277474 cites W3012418802 @default.
• W4384277474 cites W3023837329 @default.
• W4384277474 cites W3033646514 @default.
• W4384277474 cites W3159545723 @default.
• W4384277474 cites W3207078265 @default.
• W4384277474 cites W4200137911 @default.
• W4384277474 cites W4221028051 @default.
• W4384277474 cites W4283370838 @default.
• W4384277474 cites W4296632353 @default.
• W4384277474 cites W4298087335 @default.
• W4384277474 cites W4315573675 @default.
• W4384277474 cites W4367396319 @default.
• W4384277474 cites W4377107763 @default.
• W4384277474 cites W4379207239 @default.
• W4384277474 cites W3005110189 @default.
• W4384277474 doi "https://doi.org/10.1016/j.exger.2023.112254" @default.
• W4384277474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37442245" @default.
• W4384277474 hasPublicationYear "2023" @default.
• W4384277474 type Work @default.
• W4384277474 citedByCount "1" @default.
• W4384277474 countsByYear W43842774742023 @default.
• W4384277474 crossrefType "journal-article" @default.
• W4384277474 hasAuthorship W4384277474A5006053179 @default.
• W4384277474 hasAuthorship W4384277474A5034694275 @default.
• W4384277474 hasAuthorship W4384277474A5043166126 @default.
• W4384277474 hasAuthorship W4384277474A5043503596 @default.
• W4384277474 hasAuthorship W4384277474A5048052603 @default.
• W4384277474 hasAuthorship W4384277474A5052861471 @default.
• W4384277474 hasAuthorship W4384277474A5056248574 @default.
• W4384277474 hasAuthorship W4384277474A5056302980 @default.
• W4384277474 hasAuthorship W4384277474A5086295794 @default.
• W4384277474 hasAuthorship W4384277474A5088003514 @default.
• W4384277474 hasAuthorship W4384277474A5092468517 @default.
• W4384277474 hasBestOaLocation W43842774741 @default.
• W4384277474 hasConcept C126322002 @default.
• W4384277474 hasConcept C142052008 @default.
• W4384277474 hasConcept C142724271 @default.
• W4384277474 hasConcept C144024400 @default.
• W4384277474 hasConcept C149923435 @default.
• W4384277474 hasConcept C151956035 @default.
• W4384277474 hasConcept C156957248 @default.
• W4384277474 hasConcept C2778595754 @default.
• W4384277474 hasConcept C2909041561 @default.
• W4384277474 hasConcept C44249647 @default.
• W4384277474 hasConcept C71924100 @default.
• W4384277474 hasConcept C74909509 @default.
• W4384277474 hasConceptScore W4384277474C126322002 @default.
• W4384277474 hasConceptScore W4384277474C142052008 @default.
• W4384277474 hasConceptScore W4384277474C142724271 @default.

• next