Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384282289> ?p ?o ?g. }
- W4384282289 abstract "Recent analyses of public microbial genomes have found over a million biosynthetic gene clusters, the natural products of the majority of which remain unknown. Additionally, GNPS harbors billions of mass spectra of natural products without known structures and biosynthetic genes. We bridge the gap between large-scale genome mining and mass spectral datasets for natural product discovery by developing HypoRiPPAtlas, an Atlas of hypothetical natural product structures, which is ready-to-use for in silico database search of tandem mass spectra. HypoRiPPAtlas is constructed by mining genomes using seq2ripp, a machine-learning tool for the prediction of ribosomally synthesized and post-translationally modified peptides (RiPPs). In HypoRiPPAtlas, we identify RiPPs in microbes and plants. HypoRiPPAtlas could be extended to other natural product classes in the future by implementing corresponding biosynthetic logic. This study paves the way for large-scale explorations of biosynthetic pathways and chemical structures of microbial and plant RiPP classes." @default.
- W4384282289 created "2023-07-15" @default.
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- W4384282289 date "2023-07-14" @default.
- W4384282289 modified "2023-10-18" @default.
- W4384282289 title "HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search" @default.
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- W4384282289 cites W1990935073 @default.
- W4384282289 cites W1992716708 @default.
- W4384282289 cites W1996423252 @default.
- W4384282289 cites W1999893599 @default.
- W4384282289 cites W2009088711 @default.
- W4384282289 cites W2012111825 @default.
- W4384282289 cites W2012995079 @default.
- W4384282289 cites W2013619747 @default.
- W4384282289 cites W2032950096 @default.
- W4384282289 cites W2036251618 @default.
- W4384282289 cites W2044834685 @default.
- W4384282289 cites W2049202410 @default.
- W4384282289 cites W2055043387 @default.
- W4384282289 cites W2088226047 @default.
- W4384282289 cites W2089447294 @default.
- W4384282289 cites W2099273939 @default.
- W4384282289 cites W2102754716 @default.
- W4384282289 cites W2108383315 @default.
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- W4384282289 cites W2125069590 @default.
- W4384282289 cites W2126359798 @default.
- W4384282289 cites W2131887397 @default.
- W4384282289 cites W2132328461 @default.
- W4384282289 cites W2135621733 @default.
- W4384282289 cites W2142456569 @default.
- W4384282289 cites W2143485490 @default.
- W4384282289 cites W2144803530 @default.
- W4384282289 cites W2147228798 @default.
- W4384282289 cites W2162854463 @default.
- W4384282289 cites W2395466019 @default.
- W4384282289 cites W2504691963 @default.
- W4384282289 cites W2508429489 @default.
- W4384282289 cites W2528897472 @default.
- W4384282289 cites W2533385232 @default.
- W4384282289 cites W2535017472 @default.
- W4384282289 cites W2558253576 @default.
- W4384282289 cites W2593189583 @default.
- W4384282289 cites W2609551972 @default.
- W4384282289 cites W2613440185 @default.
- W4384282289 cites W2780547872 @default.
- W4384282289 cites W2793924581 @default.
- W4384282289 cites W2803753687 @default.
- W4384282289 cites W2893437991 @default.
- W4384282289 cites W2899234664 @default.
- W4384282289 cites W2944229994 @default.
- W4384282289 cites W2950570200 @default.
- W4384282289 cites W2972473680 @default.
- W4384282289 cites W2977291005 @default.
- W4384282289 cites W2980832688 @default.
- W4384282289 cites W2981262779 @default.
- W4384282289 cites W2984933828 @default.
- W4384282289 cites W2985877878 @default.
- W4384282289 cites W2996063941 @default.
- W4384282289 cites W2997918501 @default.
- W4384282289 cites W3031896406 @default.
- W4384282289 cites W3037051861 @default.
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- W4384282289 cites W3107629351 @default.
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- W4384282289 cites W3161596995 @default.
- W4384282289 cites W3170291525 @default.
- W4384282289 cites W3215934715 @default.
- W4384282289 cites W4233759802 @default.
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- W4384282289 doi "https://doi.org/10.1038/s41467-023-39905-4" @default.
- W4384282289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37452020" @default.
- W4384282289 hasPublicationYear "2023" @default.
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