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- W4384282302 abstract "Resistance to endocrine treatments and CDK4/6 inhibitors is considered a near-inevitability in most patients with estrogen receptor positive breast cancers (ER + BC). By genomic and metabolomics analyses of patients' tumours, metastasis-derived patient-derived xenografts (PDX) and isogenic cell lines we demonstrate that a fraction of metastatic ER + BC is highly reliant on oxidative phosphorylation (OXPHOS). Treatment by the OXPHOS inhibitor IACS-010759 strongly inhibits tumour growth in multiple endocrine and palbociclib resistant PDX. Mutations in the PIK3CA/AKT1 genes are significantly associated with response to IACS-010759. At the metabolic level, in vivo response to IACS-010759 is associated with decreased levels of metabolites of the glutathione, glycogen and pentose phosphate pathways in treated tumours. In vitro, endocrine and palbociclib resistant cells show increased OXPHOS dependency and increased ROS levels upon IACS-010759 treatment. Finally, in ER + BC patients, high expression of OXPHOS associated genes predict poor prognosis. In conclusion, these results identify OXPHOS as a promising target for treatment resistant ER + BC patients." @default.
- W4384282302 created "2023-07-15" @default.
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- W4384282302 date "2023-07-14" @default.
- W4384282302 modified "2023-10-14" @default.
- W4384282302 title "Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers" @default.
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- W4384282302 cites W1858562613 @default.
- W4384282302 cites W1929533080 @default.
- W4384282302 cites W1961026612 @default.
- W4384282302 cites W1975090760 @default.
- W4384282302 cites W1980270094 @default.
- W4384282302 cites W1997684038 @default.
- W4384282302 cites W2000018429 @default.
- W4384282302 cites W2014671368 @default.
- W4384282302 cites W2046178144 @default.
- W4384282302 cites W2076374687 @default.
- W4384282302 cites W2082564115 @default.
- W4384282302 cites W2114861961 @default.
- W4384282302 cites W2130410032 @default.
- W4384282302 cites W2134294354 @default.
- W4384282302 cites W2134526812 @default.
- W4384282302 cites W2148755064 @default.
- W4384282302 cites W2157230165 @default.
- W4384282302 cites W2157825442 @default.
- W4384282302 cites W2169456326 @default.
- W4384282302 cites W2267865658 @default.
- W4384282302 cites W2282588309 @default.
- W4384282302 cites W2518696212 @default.
- W4384282302 cites W2530872875 @default.
- W4384282302 cites W2560409587 @default.
- W4384282302 cites W2593043086 @default.
- W4384282302 cites W2741277091 @default.
- W4384282302 cites W2766266723 @default.
- W4384282302 cites W2806128074 @default.
- W4384282302 cites W2809388839 @default.
- W4384282302 cites W2887351902 @default.
- W4384282302 cites W2891700678 @default.
- W4384282302 cites W2895398843 @default.
- W4384282302 cites W2896846857 @default.
- W4384282302 cites W2902401096 @default.
- W4384282302 cites W2910602104 @default.
- W4384282302 cites W2921840773 @default.
- W4384282302 cites W2946820012 @default.
- W4384282302 cites W2955429336 @default.
- W4384282302 cites W2997046468 @default.
- W4384282302 cites W3007363313 @default.
- W4384282302 cites W3008140434 @default.
- W4384282302 cites W3010323140 @default.
- W4384282302 cites W3011770496 @default.
- W4384282302 cites W3015450697 @default.
- W4384282302 cites W3045595966 @default.
- W4384282302 cites W3048840742 @default.
- W4384282302 cites W3087514165 @default.
- W4384282302 cites W3119930520 @default.
- W4384282302 cites W3140011679 @default.
- W4384282302 cites W3176308859 @default.
- W4384282302 cites W3198087373 @default.
- W4384282302 cites W3198750833 @default.
- W4384282302 cites W3200632075 @default.
- W4384282302 cites W3211255002 @default.
- W4384282302 cites W4280550963 @default.
- W4384282302 cites W4282937977 @default.
- W4384282302 cites W4291954795 @default.
- W4384282302 cites W4295921704 @default.
- W4384282302 cites W4308681578 @default.
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- W4384282302 doi "https://doi.org/10.1038/s41467-023-40022-5" @default.
- W4384282302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37452026" @default.
- W4384282302 hasPublicationYear "2023" @default.
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