Matches in SemOpenAlex for { <https://semopenalex.org/work/W4384283085> ?p ?o ?g. }
- W4384283085 abstract "Abstract FMRFamides are evolutionarily conserved neuropeptides that play critical roles in behavior, energy balance, and reproduction. Here, we show that FMRFamide signaling from the nervous system is critical for the rhythmic activation of a single cell of previously unknown function, the head mesodermal cell (hmc) in C. elegans . Behavioral, calcium imaging, and genetic studies reveal that release of the FLP-22 neuropeptide from the AVL neuron in response to pacemaker signaling activates hmc every 50 s through an frpr-17 G protein-coupled receptor (GPCR) and a protein kinase A signaling cascade in hmc. hmc activation results in muscle contraction through coupling by gap junctions composed of UNC-9/Innexin. hmc activation is inhibited by the neuronal release of a second FMRFamide-like neuropeptide, FLP-9, which functions through its GPCR, frpr-21 , in hmc. This study reveals a function for two opposing FMRFamide signaling pathways in controlling the rhythmic activation of a target cell through volume transmission." @default.
- W4384283085 created "2023-07-15" @default.
- W4384283085 creator A5013455108 @default.
- W4384283085 creator A5078037780 @default.
- W4384283085 creator A5087163606 @default.
- W4384283085 creator A5090174602 @default.
- W4384283085 date "2023-07-14" @default.
- W4384283085 modified "2023-10-05" @default.
- W4384283085 title "The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic muscle contraction in C. elegans" @default.
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- W4384283085 doi "https://doi.org/10.1038/s41467-023-39955-8" @default.