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- W4384283387 abstract "Background Nonvascularized bone grafting represents a practical method of mandibular reconstruction. However, the destructive effects of radiotherapy on native bone preclude the use of nonvascularized bone grafts in head and neck cancer patients. Adipose-derived stem cells have been shown to enhance bone healing and regeneration in numerous experimental models. The purpose of this study was to determine the impact of adipose-derived stem cells on nonvascularized bone graft incorporation in a murine model of irradiated mandibular reconstruction. Methods Thirty isogenic rats were randomly divided into 3 groups: nonvascularized bone graft (control), radiation with nonvascularized bone graft (XRT), and radiation with nonvascularized bone graft and adipose-derived stem cells (ASC). Excluding the control group, all rats received a human-equivalent dose of radiation. All groups underwent mandibular reconstruction of a critical-sized defect with a nonvascularized bone graft from the contralateral hemimandible. After a 60-day recovery period, graft incorporation and bone mineralization were compared between groups. Results Compared with the control group, the XRT group demonstrated significantly decreased graft incorporation ( P = 0.011), bone mineral density ( P = 0.005), and bone volume fraction ( P = 0.001). Compared with the XRT group, the ASC group achieved a significantly increased graft incorporation ( P = 0.006), bone mineral density ( P = 0.005), and bone volume fraction ( P = 0.013). No significant differences were identified between the control and ASC groups. Conclusions Adipose-derived stem cells enhance nonvascularized bone graft incorporation in the setting of human-equivalent radiation." @default.
- W4384283387 created "2023-07-15" @default.
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- W4384283387 date "2023-07-01" @default.
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- W4384283387 title "Adipose-Derived Stem Cells Enhance Graft Incorporation and Mineralization in a Murine Model of Irradiated Mandibular Nonvascularized Bone Grafting" @default.
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- W4384283387 doi "https://doi.org/10.1097/sap.0000000000003598" @default.
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