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- W4384283453 endingPage "112796" @default.
- W4384283453 startingPage "112796" @default.
- W4384283453 abstract "The subcellular localization of proteins is critical for their functions in eukaryotic cells and is tightly correlated with protein modifications. Here, we comprehensively investigate the nuclear-cytoplasmic distributions of the phosphorylated, O-GlcNAcylated, and non-modified forms of proteins to dissect the correlation between protein distribution and modifications. Phosphorylated and O-GlcNAcylated proteins have overall higher nuclear distributions than non-modified ones. Different distributions among the phosphorylated, O-GlcNAcylated, and non-modified forms of proteins are associated with protein size, structure, and function, as well as local environment and adjacent residues around modification sites. Moreover, we perform site-mutagenesis experiments using phosphomimetic and phospho-null mutants of two proteins to validate the proteomic results. Additionally, the effects of the OGT/OGA inhibition on glycoprotein distribution are systematically investigated, and the distribution changes of glycoproteins are related to their abundance changes under the inhibitions. Systematic investigation of the relationship between protein modification and localization advances our understanding of protein functions." @default.
- W4384283453 created "2023-07-15" @default.
- W4384283453 creator A5012718334 @default.
- W4384283453 creator A5019829909 @default.
- W4384283453 creator A5056409749 @default.
- W4384283453 creator A5058043055 @default.
- W4384283453 date "2023-07-01" @default.
- W4384283453 modified "2023-10-17" @default.
- W4384283453 title "Systematic analysis of the impact of phosphorylation and O-GlcNAcylation on protein subcellular localization" @default.
- W4384283453 cites W1513083741 @default.
- W4384283453 cites W1560616913 @default.
- W4384283453 cites W1591236566 @default.
- W4384283453 cites W1808845588 @default.
- W4384283453 cites W1917449639 @default.
- W4384283453 cites W196882932 @default.
- W4384283453 cites W1971436788 @default.
- W4384283453 cites W1975304761 @default.
- W4384283453 cites W1977637361 @default.
- W4384283453 cites W1981609001 @default.
- W4384283453 cites W1983400295 @default.
- W4384283453 cites W1993450321 @default.
- W4384283453 cites W1993548347 @default.
- W4384283453 cites W2005750609 @default.
- W4384283453 cites W2006189460 @default.
- W4384283453 cites W2006796385 @default.
- W4384283453 cites W2015343674 @default.
- W4384283453 cites W2015941534 @default.
- W4384283453 cites W2017380123 @default.
- W4384283453 cites W2020291366 @default.
- W4384283453 cites W2023620203 @default.
- W4384283453 cites W2023651881 @default.
- W4384283453 cites W2025624075 @default.
- W4384283453 cites W2026320744 @default.
- W4384283453 cites W2026465178 @default.
- W4384283453 cites W2026926544 @default.
- W4384283453 cites W2031028006 @default.
- W4384283453 cites W2036316728 @default.
- W4384283453 cites W2036490858 @default.
- W4384283453 cites W2037257739 @default.
- W4384283453 cites W2042044881 @default.
- W4384283453 cites W2048492672 @default.
- W4384283453 cites W2048666997 @default.
- W4384283453 cites W2051959262 @default.
- W4384283453 cites W2059725389 @default.
- W4384283453 cites W2060744329 @default.
- W4384283453 cites W2067099248 @default.
- W4384283453 cites W2074146315 @default.
- W4384283453 cites W2084634779 @default.
- W4384283453 cites W2089693526 @default.
- W4384283453 cites W2090990735 @default.
- W4384283453 cites W2096057003 @default.
- W4384283453 cites W2102971263 @default.
- W4384283453 cites W2103262274 @default.
- W4384283453 cites W2104221028 @default.
- W4384283453 cites W2114154858 @default.
- W4384283453 cites W2116423958 @default.
- W4384283453 cites W2127960611 @default.
- W4384283453 cites W2135372082 @default.
- W4384283453 cites W2138057083 @default.
- W4384283453 cites W2142583027 @default.
- W4384283453 cites W2144781426 @default.
- W4384283453 cites W2147008614 @default.
- W4384283453 cites W2152446105 @default.
- W4384283453 cites W2154522012 @default.
- W4384283453 cites W2158217645 @default.
- W4384283453 cites W2158953193 @default.
- W4384283453 cites W2164933850 @default.
- W4384283453 cites W2167279371 @default.
- W4384283453 cites W2218364825 @default.
- W4384283453 cites W2302020441 @default.
- W4384283453 cites W2347067222 @default.
- W4384283453 cites W2467079299 @default.
- W4384283453 cites W2529399130 @default.
- W4384283453 cites W2615402641 @default.
- W4384283453 cites W2756444346 @default.
- W4384283453 cites W2765258427 @default.
- W4384283453 cites W2766375531 @default.
- W4384283453 cites W2794589 @default.
- W4384283453 cites W2804509374 @default.
- W4384283453 cites W2895737508 @default.
- W4384283453 cites W2900701906 @default.
- W4384283453 cites W2901553675 @default.
- W4384283453 cites W2905801034 @default.
- W4384283453 cites W2927478759 @default.
- W4384283453 cites W2937573806 @default.
- W4384283453 cites W2950374603 @default.
- W4384283453 cites W2950456125 @default.
- W4384283453 cites W2951852411 @default.
- W4384283453 cites W2994464657 @default.
- W4384283453 cites W3036323520 @default.
- W4384283453 cites W3043576199 @default.
- W4384283453 cites W3082608639 @default.
- W4384283453 cites W3110571152 @default.
- W4384283453 cites W3134824952 @default.
- W4384283453 cites W3136918052 @default.
- W4384283453 cites W3157808708 @default.
- W4384283453 cites W3158633159 @default.
- W4384283453 cites W3165851349 @default.